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Wnt5b wingless-type MMTV integration site family, member 5B [ Mus musculus (house mouse) ]

Gene ID: 22419, updated on 21-Mar-2023

Summary

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Official Symbol
Wnt5bprovided by MGI
Official Full Name
wingless-type MMTV integration site family, member 5Bprovided by MGI
Primary source
MGI:MGI:98959
See related
Ensembl:ENSMUSG00000030170 AllianceGenome:MGI:98959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wnt-5b
Summary
Enables signaling receptor binding activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of fat cell differentiation. Located in cell surface and extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human WNT5B (Wnt family member 5B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 4.7), limb E14.5 (RPKM 3.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Wnt5b in Genome Data Viewer
Location:
6 F1; 6 56.86 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (119409492..119521880, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (119432531..119544824, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 4 Neighboring gene leucine-rich repeats and transmembrane domains 2 Neighboring gene adiponectin receptor 2 Neighboring gene predicted gene, 40397 Neighboring gene F-box and leucine-rich repeat protein 14 Neighboring gene predicted gene, 30690 Neighboring gene predicted gene, 52875 Neighboring gene ELKS/RAB6-interacting/CAST family member 1 Neighboring gene RIKEN cDNA 3110021A11 gene Neighboring gene family with sequence similarity 76, member A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Wnt signaling contributes to withdrawal symptoms from opioid receptor activation induced by morphine exposure or chronic inflammation. Wu M, et al. Pain, 2020 Mar. PMID 31738230, Free PMC Article
  2. Wnt5b regulates mesenchymal cell aggregation and chondrocyte differentiation through the planar cell polarity pathway. Bradley EW, et al. J Cell Physiol, 2011 Jun. PMID 21413026
  3. Mesenchymal WNT-5A/5B Signaling Represses Lung Alveolar Epithelial Progenitors. Wu X, et al. Cells, 2019 Sep 25. PMID 31557955, Free PMC Article
  4. Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation. Kuorelahti A, et al. Endocrinology, 2007 Aug. PMID 17510243
  5. Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes. Kanazawa A, et al. Biochem Biophys Res Commun, 2005 May 6. PMID 15796911

See all (126) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Wnt signaling contributes to withdrawal symptoms from opioid receptor activation induced by morphine exposure or chronic inflammation.
    Title: Wnt signaling contributes to withdrawal symptoms from opioid receptor activation induced by morphine exposure or chronic inflammation.
  2. Results found that WNT-5B expression level is enhanced in ageing mice. WNT-5B repress the growth of lung organoid co-cultures of fibroblasts and epithelial progenitors, and preferentially restraining both the growth and differentiation of the alveolar epithelial progenitors. These results provide evidence that WNT-5B, along with WNT-5A negatively regulate the canonical WNT signaling pathway in alveolar epithelium.
    Title: Mesenchymal WNT-5A/5B Signaling Represses Lung Alveolar Epithelial Progenitors.
  3. opposing gradients of Wnt5a and Wnt5b and of their Sfrp inhibitors, together with intercellular signaling via planar cell polarity proteins, polarize node cells along the anterior-posterior axis for breaking of left-right symmetry.
    Title: A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.
  4. Wnt5b activated known calcium-dependent signaling pathways and JNK, a component of the planar cell polarity pathway.
    Title: Wnt5b regulates mesenchymal cell aggregation and chondrocyte differentiation through the planar cell polarity pathway.
  5. this study aimed at defining the expression profile and function of Wnt5a and Wnt5b during adipogenesis by determining their effect on aP2 and PPARgamma expression and assessing the level of beta-catenin translocation in mouse 3T3-L1 preadipocytes.
    Title: Wnt5b stimulates adipogenesis by activating PPARgamma, and inhibiting the beta-catenin dependent Wnt signaling pathway together with Wnt5a.
  6. hCG was found to up-regulate these wnt ligands in mouse mammary gland, independent of the changes in ovarian steroidogenesis
    Title: Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation.
  7. Wnt5b may promote adipogenesis in 3T3-L1 cells, at least in part, by antagonizing the canonical Wnt/beta-catenin pathway
    Title: Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes.
  8. Secreted Wnt glycoproteins, expressed by thymic epithelial cells and thymocytes, regulate epithelial Foxn1 expression in both autocrine and paracrine fashions. Wnt molecules therefore provide regulatory signals critical for thymic function.
    Title: Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice.
  9. Data indicate that Wnt5a and Wnt5b control the pace of transitions between different chondrocyte zones.
    Title: Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within animal organ morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within cell-cell signaling TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of fat cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
protein Wnt-5b
Names
wingless-related MMTV integration site 5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271757.2 → NP_001258686.1  protein Wnt-5b precursor

    See identical proteins and their annotated locations for NP_001258686.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC126607
    Consensus CDS
    CCDS20474.2
    UniProtKB/Swiss-Prot
    P22726, Q91XF5
    Related
    ENSMUSP00000113188.2, ENSMUST00000117171.8
    Conserved Domains (1) summary
    pfam00110
    Location:54 → 359
    wnt; wnt family

  2. NM_001271758.2 → NP_001258687.1  protein Wnt-5b precursor

    See identical proteins and their annotated locations for NP_001258687.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC126607
    Consensus CDS
    CCDS20474.2
    UniProtKB/Swiss-Prot
    P22726, Q91XF5
    Related
    ENSMUSP00000112819.2, ENSMUST00000118120.8
    Conserved Domains (1) summary
    pfam00110
    Location:54 → 359
    wnt; wnt family

  3. NM_001410505.1 → NP_001397434.1  protein Wnt-5b precursor

    Status: VALIDATED

    Source sequence(s)
    AC126607, AC128662
    UniProtKB/Swiss-Prot
    Q91XF5

  4. NM_009525.4 → NP_033551.2  protein Wnt-5b precursor

    See identical proteins and their annotated locations for NP_033551.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC126607, AC128662
    Consensus CDS
    CCDS20474.2
    UniProtKB/Swiss-Prot
    P22726, Q91XF5
    Related
    ENSMUSP00000137065.2, ENSMUST00000178696.8
    Conserved Domains (1) summary
    pfam00110
    Location:54 → 359
    wnt; wnt family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    119409492..119521880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505924.2 → XP_006505987.1  protein Wnt-5b isoform X2

    UniProtKB/Swiss-Prot
    P22726
    UniProtKB/TrEMBL
    A0A0R4J1M1
    Conserved Domains (1) summary
    cd19348
    Location:61 → 372
    Wnt_Wnt5b; Wnt domain found in protein Wnt-5b and similar proteins

  2. XM_036166025.1 → XP_036021918.1  protein Wnt-5b isoform X1

    Conserved Domains (1) summary
    cd19348
    Location:83 → 394
    Wnt_Wnt5b; Wnt domain found in protein Wnt-5b and similar proteins

  3. XM_036166026.1 → XP_036021919.1  protein Wnt-5b isoform X2

    UniProtKB/TrEMBL
    A0A0R4J1M1, A0A8C6GS12
    Conserved Domains (1) summary
    cd19348
    Location:61 → 372
    Wnt_Wnt5b; Wnt domain found in protein Wnt-5b and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22726.2 GenPept UniProtKB/Swiss-Prot:P22726

Gene LinkOut

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