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Wnt5b wingless-type MMTV integration site family, member 5B [ Mus musculus (house mouse) ]

Gene ID: 22419, updated on 27-Feb-2024

Summary

Official Symbol
Wnt5bprovided by MGI
Official Full Name
wingless-type MMTV integration site family, member 5Bprovided by MGI
Primary source
MGI:MGI:98959
See related
Ensembl:ENSMUSG00000030170 AllianceGenome:MGI:98959
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wnt-5b
Summary
Enables signaling receptor binding activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of fat cell differentiation. Located in cell surface and extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human WNT5B (Wnt family member 5B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 4.7), limb E14.5 (RPKM 3.9) and 25 other tissues See more
Orthologs
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Genomic context

See Wnt5b in Genome Data Viewer
Location:
6 F1; 6 56.86 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (119409493..119521847, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (119432531..119544824, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:119286263-119286553 Neighboring gene leucine-rich repeats and transmembrane domains 2 Neighboring gene STARR-positive B cell enhancer ABC_E9099 Neighboring gene adiponectin receptor 2 Neighboring gene STARR-seq mESC enhancer starr_17147 Neighboring gene STARR-seq mESC enhancer starr_17149 Neighboring gene predicted gene, 40397 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:119472087-119472240 Neighboring gene F-box and leucine-rich repeat protein 14 Neighboring gene predicted gene, 30690 Neighboring gene predicted gene, 52875 Neighboring gene ELKS/RAB6-interacting/CAST family member 1 Neighboring gene STARR-seq mESC enhancer starr_17152 Neighboring gene RIKEN cDNA 3110021A11 gene Neighboring gene STARR-seq mESC enhancer starr_17154 Neighboring gene family with sequence similarity 76, member A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein Wnt-5b
Names
wingless-related MMTV integration site 5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271757.2NP_001258686.1  protein Wnt-5b precursor

    See identical proteins and their annotated locations for NP_001258686.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC126607
    Consensus CDS
    CCDS20474.2
    UniProtKB/Swiss-Prot
    P22726, Q91XF5
    UniProtKB/TrEMBL
    D3YTW9
    Related
    ENSMUSP00000113188.2, ENSMUST00000117171.8
    Conserved Domains (1) summary
    pfam00110
    Location:54359
    wnt; wnt family
  2. NM_001271758.2NP_001258687.1  protein Wnt-5b precursor

    See identical proteins and their annotated locations for NP_001258687.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC126607
    Consensus CDS
    CCDS20474.2
    UniProtKB/Swiss-Prot
    P22726, Q91XF5
    UniProtKB/TrEMBL
    D3YTW9
    Related
    ENSMUSP00000112819.2, ENSMUST00000118120.8
    Conserved Domains (1) summary
    pfam00110
    Location:54359
    wnt; wnt family
  3. NM_001410505.1NP_001397434.1  protein Wnt-5b precursor

    Status: VALIDATED

    Source sequence(s)
    AC126607, AC128662
    UniProtKB/Swiss-Prot
    P22726, Q91XF5
    UniProtKB/TrEMBL
    D3YTW9
  4. NM_009525.4NP_033551.2  protein Wnt-5b precursor

    See identical proteins and their annotated locations for NP_033551.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC126607, AC128662
    Consensus CDS
    CCDS20474.2
    UniProtKB/Swiss-Prot
    P22726, Q91XF5
    UniProtKB/TrEMBL
    D3YTW9
    Related
    ENSMUSP00000137065.2, ENSMUST00000178696.8
    Conserved Domains (1) summary
    pfam00110
    Location:54359
    wnt; wnt family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    119409493..119521847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166025.1XP_036021918.1  protein Wnt-5b isoform X1

    UniProtKB/TrEMBL
    D3YTW9
    Conserved Domains (1) summary
    cd19348
    Location:83394
    Wnt_Wnt5b; Wnt domain found in protein Wnt-5b and similar proteins
  2. XM_036166026.1XP_036021919.1  protein Wnt-5b isoform X2

    UniProtKB/TrEMBL
    A0A0R4J1M1, D3YTW9
    Conserved Domains (1) summary
    cd19348
    Location:61372
    Wnt_Wnt5b; Wnt domain found in protein Wnt-5b and similar proteins