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WNT5B Wnt family member 5B [ Homo sapiens (human) ]

Gene ID: 81029, updated on 8-Jul-2021

Summary

Official Symbol
WNT5Bprovided by HGNC
Official Full Name
Wnt family member 5Bprovided by HGNC
Primary source
HGNC:HGNC:16265
See related
Ensembl:ENSG00000111186 MIM:606361
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Expression
Broad expression in prostate (RPKM 12.1), esophagus (RPKM 5.6) and 21 other tissues See more
Orthologs
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Genomic context

See WNT5B in Genome Data Viewer
Location:
12p13.33
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (1529856..1647213)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (1726222..1756378)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ELKS/RAB6-interacting/CAST family member 1 Neighboring gene uncharacterized LOC107987182 Neighboring gene uncharacterized LOC107984507 Neighboring gene long intergenic non-protein coding RNA 942 Neighboring gene F-box and leucine rich repeat protein 14 Neighboring gene SDA1 domain containing 1 pseudogene Neighboring gene microRNA 3649 Neighboring gene adiponectin receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2648

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chondrocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in fat cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in lens fiber cell development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of convergent extension involved in gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of non-canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in wound healing IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein Wnt-5b
Names
WNT-5B protein
wingless-type MMTV integration site family, member 5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030775.2NP_110402.2  protein Wnt-5b precursor

    See identical proteins and their annotated locations for NP_110402.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs from variant 1 in the 5' UTR, which results from an alternate exon. Both variants encode the same protein.
    Source sequence(s)
    AY009399
    Consensus CDS
    CCDS8510.1
    UniProtKB/Swiss-Prot
    Q9H1J7
    Related
    ENSP00000308887.3, ENST00000310594.7
    Conserved Domains (1) summary
    pfam00110
    Location:50359
    wnt; wnt family
  2. NM_032642.3NP_116031.1  protein Wnt-5b precursor

    See identical proteins and their annotated locations for NP_116031.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs from variant 2 in the 5' UTR, which results from an alternate exon. Both variants encode the same protein.
    Source sequence(s)
    AC005182
    Consensus CDS
    CCDS8510.1
    UniProtKB/Swiss-Prot
    Q9H1J7
    Related
    ENSP00000380379.2, ENST00000397196.7
    Conserved Domains (1) summary
    pfam00110
    Location:50359
    wnt; wnt family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    1529856..1647213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449207.1XP_024304975.1  protein Wnt-5b isoform X3

    Related
    ENSP00000439312.1, ENST00000537031.5
    Conserved Domains (1) summary
    pfam00110
    Location:50359
    wnt; wnt family
  2. XM_024449204.1XP_024304972.1  protein Wnt-5b isoform X2

    Conserved Domains (1) summary
    pfam00110
    Location:71380
    wnt; wnt family
  3. XM_024449205.1XP_024304973.1  protein Wnt-5b isoform X3

    Conserved Domains (1) summary
    pfam00110
    Location:50359
    wnt; wnt family
  4. XM_024449209.1XP_024304977.1  protein Wnt-5b isoform X3

    Conserved Domains (1) summary
    pfam00110
    Location:50359
    wnt; wnt family
  5. XM_024449203.1XP_024304971.1  protein Wnt-5b isoform X1

    Conserved Domains (1) summary
    pfam00110
    Location:102411
    wnt; wnt family
  6. XM_024449208.1XP_024304976.1  protein Wnt-5b isoform X3

    Conserved Domains (1) summary
    pfam00110
    Location:50359
    wnt; wnt family
  7. XM_024449206.1XP_024304974.1  protein Wnt-5b isoform X3

    Conserved Domains (1) summary
    pfam00110
    Location:50359
    wnt; wnt family
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