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Wnt11 wingless-type MMTV integration site family, member 11 [ Mus musculus (house mouse) ]

Gene ID: 22411, updated on 17-Jan-2023

Summary

Official Symbol
Wnt11provided by MGI
Official Full Name
wingless-type MMTV integration site family, member 11provided by MGI
Primary source
MGI:MGI:101948
See related
Ensembl:ENSMUSG00000015957 AllianceGenome:MGI:101948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable enzyme activator activity and signaling receptor binding activity. Involved in heart development and positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including Wnt signaling pathway; animal organ development; and regulation of cytokine production. Located in extracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and limb. Orthologous to human WNT11 (Wnt family member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 15.3), limb E14.5 (RPKM 15.2) and 16 other tissues See more
Orthologs
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Genomic context

See Wnt11 in Genome Data Viewer
Location:
7 E1; 7 53.9 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (98484293..98503954)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (98835084..98854747)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA proline 7 (anticodon AGG) Neighboring gene predicted gene, 39054 Neighboring gene predicted gene, 33770 Neighboring gene predicted gene, 33827 Neighboring gene UV radiation resistance associated gene Neighboring gene predicted gene 8149

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrial septum development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within bicellular tight junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bone mineralization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cellular response to mechanical stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within convergent extension involved in axis elongation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial to mesenchymal transition IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within kidney development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within maintenance of epithelial cell apical/basal polarity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fibroblast growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuroendocrine cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within non-canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within notochord morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within paraxial mesoderm formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in axis elongation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in gastrula mediolateral intercalation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transforming growth factor beta2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in primary heart field specification IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within roof of mouth development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in secondary heart field specification IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in secondary palate development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within somite development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular septum development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein Wnt-11
Names
wingless-related MMTV integration site 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285792.1NP_001272721.1  protein Wnt-11 isoform a precursor

    See identical proteins and their annotated locations for NP_001272721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC110039, AK031573, AK077828, AK138967
    Consensus CDS
    CCDS21475.1
    UniProtKB/Swiss-Prot
    P48615
    UniProtKB/TrEMBL
    A0A6P7RFD8, A0A8C6N325, Q059Y4, Q3UTY8
    Related
    ENSMUSP00000064333.3, ENSMUST00000067495.9
    Conserved Domains (1) summary
    cd19343
    Location:51354
    Wnt_Wnt11; Wnt domain found in protein Wnt-11 and similar proteins
  2. NM_001285794.1NP_001272723.1  protein Wnt-11 isoform b

    See identical proteins and their annotated locations for NP_001272723.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses a downstream start codon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AK031573, AK138967
    UniProtKB/TrEMBL
    Q3UTY8
    Conserved Domains (1) summary
    pfam00110
    Location:1289
    wnt; wnt family
  3. NM_001285795.1NP_001272724.1  protein Wnt-11 isoform c

    See identical proteins and their annotated locations for NP_001272724.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice junction compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC110039, AK031573, BC125482
    UniProtKB/TrEMBL
    A0A6P5Q373, Q059Y4
    Conserved Domains (1) summary
    cl38924
    Location:32185
    Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family
  4. NM_009519.2NP_033545.1  protein Wnt-11 isoform a precursor

    See identical proteins and their annotated locations for NP_033545.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC110039, BC125484
    Consensus CDS
    CCDS21475.1
    UniProtKB/Swiss-Prot
    P48615
    UniProtKB/TrEMBL
    A0A6P7RFD8, A0A8C6N325, Q059Y4
    Related
    ENSMUSP00000132166.2, ENSMUST00000167303.8
    Conserved Domains (1) summary
    cd19343
    Location:51354
    Wnt_Wnt11; Wnt domain found in protein Wnt-11 and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    98484293..98503954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507587.5XP_006507650.1  protein Wnt-11 isoform X3

    See identical proteins and their annotated locations for XP_006507650.1

    UniProtKB/TrEMBL
    A0A6P5Q373
    Conserved Domains (1) summary
    cl38924
    Location:32185
    Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family
  2. XM_006507586.5XP_006507649.1  protein Wnt-11 isoform X1

    See identical proteins and their annotated locations for XP_006507649.1

    UniProtKB/Swiss-Prot
    P48615
    UniProtKB/TrEMBL
    A0A6P7RFD8, A0A8C6N325, Q059Y4
    Conserved Domains (1) summary
    cd19343
    Location:51354
    Wnt_Wnt11; Wnt domain found in protein Wnt-11 and similar proteins
  3. XM_011241733.2XP_011240035.1  protein Wnt-11 isoform X2

    Conserved Domains (1) summary
    cd19343
    Location:69223
    Wnt_Wnt11; Wnt domain found in protein Wnt-11 and similar proteins