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WNT11 Wnt family member 11 [ Homo sapiens (human) ]

Gene ID: 7481, updated on 9-Feb-2020

Summary

Official Symbol
WNT11provided by HGNC
Official Full Name
Wnt family member 11provided by HGNC
Primary source
HGNC:HGNC:12776
See related
Ensembl:ENSG00000085741 MIM:603699
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HWNT11
Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 7.4), adrenal (RPKM 3.7) and 15 other tissues See more
Orthologs

Genomic context

See WNT11 in Genome Data Viewer
Location:
11q13.5
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (76186325..76210842, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (75897370..75921803, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene UV radiation resistance associated Neighboring gene VISTA enhancer hs1435 Neighboring gene Sharpr-MPRA regulatory region 10154 Neighboring gene uncharacterized LOC112268079 Neighboring gene CRISPRi-validated cis-regulatory element chr11.4413 Neighboring gene long intergenic non-protein coding RNA 2761

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC141946, MGC141948

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
frizzled binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway, calcium modulating pathway NAS
Non-traceable Author Statement
more info
PubMed 
Wnt signaling pathway, planar cell polarity pathway NAS
Non-traceable Author Statement
more info
PubMed 
Wnt signaling pathway, planar cell polarity pathway TAS
Traceable Author Statement
more info
 
activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
adrenal gland development IEP
Inferred from Expression Pattern
more info
PubMed 
artery morphogenesis IEA
Inferred from Electronic Annotation
more info
 
bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
 
bone mineralization IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
cloacal septation IEP
Inferred from Expression Pattern
more info
PubMed 
convergent extension involved in axis elongation IEA
Inferred from Electronic Annotation
more info
 
embryonic skeletal system development IEP
Inferred from Expression Pattern
more info
PubMed 
epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
 
lung-associated mesenchyme development IEP
Inferred from Expression Pattern
more info
PubMed 
maintenance of epithelial cell apical/basal polarity IEA
Inferred from Electronic Annotation
more info
 
mesonephric duct development IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cartilage development NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fibroblast growth factor production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuroendocrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
notochord morphogenesis IEA
Inferred from Electronic Annotation
more info
 
osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
paraxial mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
planar cell polarity pathway involved in axis elongation IEA
Inferred from Electronic Annotation
more info
 
planar cell polarity pathway involved in gastrula mediolateral intercalation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase C signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transforming growth factor beta2 production IEA
Inferred from Electronic Annotation
more info
 
protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
secondary palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
somite development IEA
Inferred from Electronic Annotation
more info
 
ureteric bud morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
ventricular septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein Wnt-11
Names
wingless-type MMTV integration site family, member 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046931.1 RefSeqGene

    Range
    12507..32684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004626.3NP_004617.2  protein Wnt-11 precursor

    See identical proteins and their annotated locations for NP_004617.2

    Status: REVIEWED

    Source sequence(s)
    AP000785
    Consensus CDS
    CCDS8242.1
    UniProtKB/Swiss-Prot
    O96014
    Related
    ENSP00000325526.3, ENST00000322563.8
    Conserved Domains (1) summary
    smart00097
    Location:47354
    WNT1; found in Wnt-1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    76186325..76210842 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545240.2XP_011543542.1  protein Wnt-11 isoform X1

    See identical proteins and their annotated locations for XP_011543542.1

    Conserved Domains (1) summary
    cl19568
    Location:47364
    wnt; wnt family
  2. XM_011545239.2XP_011543541.1  protein Wnt-11 isoform X1

    See identical proteins and their annotated locations for XP_011543541.1

    Conserved Domains (1) summary
    cl19568
    Location:47364
    wnt; wnt family
  3. XM_005274231.1XP_005274288.1  protein Wnt-11 isoform X2

    See identical proteins and their annotated locations for XP_005274288.1

    UniProtKB/Swiss-Prot
    O96014
    Conserved Domains (1) summary
    smart00097
    Location:47354
    WNT1; found in Wnt-1
  4. XM_011545238.1XP_011543540.1  protein Wnt-11 isoform X1

    See identical proteins and their annotated locations for XP_011543540.1

    Conserved Domains (1) summary
    cl19568
    Location:47364
    wnt; wnt family
  5. XM_024448678.1XP_024304446.1  protein Wnt-11 isoform X3

    Conserved Domains (1) summary
    cl19568
    Location:32185
    wnt; wnt family

RNA

  1. XR_002957190.1 RNA Sequence

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