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Wnt1 wingless-type MMTV integration site family, member 1 [ Mus musculus (house mouse) ]

Gene ID: 22408, updated on 27-Feb-2024

Summary

Official Symbol
Wnt1provided by MGI
Official Full Name
wingless-type MMTV integration site family, member 1provided by MGI
Primary source
MGI:MGI:98953
See related
Ensembl:ENSMUSG00000022997 AllianceGenome:MGI:98953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sw; Int-1; Wnt-1; swaying
Summary
Enables cytokine activity and protein domain specific binding activity. Involved in several processes, including astrocyte-dopaminergic neuron signaling; central nervous system development; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; regulation of cellular protein metabolic process; and ubiquitin-dependent SMAD protein catabolic process. Located in cell surface and extracellular region. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo ectoderm; and genitourinary system. Used to study breast cancer. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 15 and osteoporosis. Orthologous to human WNT1 (Wnt family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 2.1), testis adult (RPKM 1.8) and 5 other tissues See more
Orthologs
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Genomic context

See Wnt1 in Genome Data Viewer
Location:
15 F1; 15 54.65 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98687738..98691711)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98789857..98793830)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor 3 Neighboring gene uncharacterized LOC115488470 Neighboring gene wingless-type MMTV integration site family, member 10B Neighboring gene dendrin Neighboring gene protein kinase, AMP-activated, gamma 1 non-catalytic subunit Neighboring gene STARR-positive B cell enhancer ABC_E1918

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in Spemann organizer formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell differentiation in thymus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in animal organ regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in bone development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical Wnt signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell proliferation in midbrain IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in central nervous system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebellum formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within diencephalon development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopaminergic neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in embryonic axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic brain development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within forebrain anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hepatocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within metencephalon development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in midbrain development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within midbrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in midbrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in midbrain dopaminergic neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in midbrain dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within midbrain-hindbrain boundary development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within midbrain-hindbrain boundary maturation during brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within myoblast fusion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within myoblast fusion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within myotube differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neuron fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of dermatome development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spinal cord association neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Wnt signalosome IC
Inferred by Curator
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
proto-oncogene Wnt-1
Names
proto-oncogene Int-1
proto-oncogene protein Wnt-1
wingless-related MMTV integration site 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021279.4NP_067254.1  proto-oncogene Wnt-1 precursor

    See identical proteins and their annotated locations for NP_067254.1

    Status: VALIDATED

    Source sequence(s)
    AC156543, AK141669
    Consensus CDS
    CCDS27807.1
    UniProtKB/Swiss-Prot
    P04426
    UniProtKB/TrEMBL
    Q3UR96
    Related
    ENSMUSP00000023734.8, ENSMUST00000023734.8
    Conserved Domains (1) summary
    smart00097
    Location:60370
    WNT1; found in Wnt-1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98687738..98691711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)