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Vnn1 vanin 1 [ Mus musculus (house mouse) ]

Gene ID: 22361, updated on 1-Mar-2024

Summary

Official Symbol
Vnn1provided by MGI
Official Full Name
vanin 1provided by MGI
Primary source
MGI:MGI:108395
See related
Ensembl:ENSMUSG00000037440 AllianceGenome:MGI:108395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
V-1
Summary
Predicted to enable pantetheine hydrolase activity. Involved in several processes, including chronic inflammatory response; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and positive regulation of T cell differentiation in thymus. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; facial bone primordium; genitourinary system; nervous system; and respiratory system. Orthologous to human VNN1 (vanin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 31.3), placenta adult (RPKM 24.5) and 8 other tissues See more
Orthologs
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Genomic context

See Vnn1 in Genome Data Viewer
Location:
10 A4; 10 11.33 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (23770586..23781242)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (23894688..23905344)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26049 Neighboring gene solute carrier family 18, subfamily B, member 1 Neighboring gene STARR-seq mESC enhancer starr_26051 Neighboring gene STARR-positive B cell enhancer ABC_E8327 Neighboring gene STARR-seq mESC enhancer starr_26053 Neighboring gene vanin 3 Neighboring gene STARR-seq mESC enhancer starr_26055 Neighboring gene STARR-seq mESC enhancer starr_26056 Neighboring gene trace amine-associated receptor 1 Neighboring gene trace amine-associated receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GPI anchor binding TAS
Traceable Author Statement
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
 
enables pantetheine hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pantetheine hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pantetheine hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
NOT located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in extracellular space TAS
Traceable Author Statement
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pantetheinase
Names
pantetheine hydrolase
vascular non-inflammatory molecule 1
NP_035834.2
XP_006512781.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011704.3NP_035834.2  pantetheinase precursor

    See identical proteins and their annotated locations for NP_035834.2

    Status: VALIDATED

    Source sequence(s)
    AK145984, BB838710
    Consensus CDS
    CCDS35868.1
    UniProtKB/Swiss-Prot
    Q3TJI0, Q8VCT1, Q9DCH8, Q9Z0K8
    Related
    ENSMUSP00000040599.8, ENSMUST00000041416.8
    Conserved Domains (1) summary
    cd07567
    Location:27324
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    23770586..23781242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512718.3XP_006512781.1  pantetheinase isoform X1

    UniProtKB/TrEMBL
    Q3UEK0
    Conserved Domains (1) summary
    cl11424
    Location:1184
    nitrilase; Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes