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VNN1 vanin 1 [ Homo sapiens (human) ]

Gene ID: 8876, updated on 1-Jun-2020

Summary

Official Symbol
VNN1provided by HGNC
Official Full Name
vanin 1provided by HGNC
Primary source
HGNC:HGNC:12705
See related
Ensembl:ENSG00000112299 MIM:603570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HDLCQ8; Tiff66
Summary
This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]
Expression
Biased expression in duodenum (RPKM 74.9), liver (RPKM 69.9) and 5 other tissues See more
Orthologs

Genomic context

See VNN1 in Genome Data Viewer
Location:
6q23.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (132680849..132714055, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (133001997..133035194, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene trace amine associated receptor 1 Neighboring gene HLF pseudogene 1 Neighboring gene cyclin G1 pseudogene 1 Neighboring gene vanin 3 Neighboring gene vanin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC116930, MGC116931, MGC116932, MGC116933

Gene Ontology Provided by GOA

Function Evidence Code Pubs
pantetheine hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pantetheine hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acute inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
chronic inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
pantothenate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pantothenate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
pantothenate metabolic process TAS
Traceable Author Statement
more info
 
positive regulation of T cell differentiation in thymus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
response to oxidative stress TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
azurophil granule membrane TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
pantetheinase
Names
pantetheine hydrolase
vannin 1
vascular non-inflammatory molecule 1
NP_004657.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012147.1 RefSeqGene

    Range
    5001..38207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004666.3NP_004657.2  pantetheinase precursor

    See identical proteins and their annotated locations for NP_004657.2

    Status: REVIEWED

    Source sequence(s)
    AL032821, BC096266, BJ995136
    Consensus CDS
    CCDS5159.1
    UniProtKB/Swiss-Prot
    O95497
    Related
    ENSP00000356905.4, ENST00000367928.5
    Conserved Domains (1) summary
    cd07567
    Location:25330
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    132680849..132714055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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