U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vegfa vascular endothelial growth factor A [ Mus musculus (house mouse) ]

Gene ID: 22339, updated on 22-Jan-2023

Summary

Official Symbol
Vegfaprovided by MGI
Official Full Name
vascular endothelial growth factor Aprovided by MGI
Primary source
MGI:MGI:103178
See related
Ensembl:ENSMUSG00000023951 AllianceGenome:MGI:103178
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vpf; Vegf
Summary
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.[provided by RefSeq, Nov 2015]
Expression
Broad expression in lung adult (RPKM 187.9), adrenal adult (RPKM 89.7) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Vegfa in Genome Data Viewer
Location:
17 C; 17 22.79 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46327919..46343303, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46016993..46032377, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm591 Neighboring gene predicted gene, 41584 Neighboring gene predicted gene, 41585 Neighboring gene predicted gene, 36122 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide K pseudogene Neighboring gene mitochondrial ribosomal protein S18A Neighboring gene radial spoke head 9 homolog (Chlamydomonas)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (13)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemoattractant activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemoattractant activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables neuropilin binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor receptor 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor receptor 1 binding ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor receptor 2 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables vascular endothelial growth factor receptor 2 binding ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T-helper 1 type immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in VEGF-activated neuropilin signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in VEGF-activated neuropilin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis involved in coronary vascular morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in basophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bone trabecula formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bone trabecula morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac vascular smooth muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular stress response to acid chemical ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in commissural neuron axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in commissural neuron axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in commissural neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in coronary artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in coronary vein morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dopaminergic neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within eye photoreceptor cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in induction of positive chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in induction of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lung alveolus development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymph vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of lymphangiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within lymphangiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mRNA stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in motor neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of adherens junction organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood-brain barrier permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of CREB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in positive regulation of axon extension involved in axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of axon extension involved in axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of branching involved in ureteric bud morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration by vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epithelial tube formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of lymphangiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of mast cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of mast cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase D signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to early endosome ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of retinal ganglion cell axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of trophoblast cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of vascular permeability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within primitive erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of endothelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of hematopoietic progenitor cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
NOT involved_in regulation of retinal ganglion cell axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of retinal ganglion cell axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of retinal ganglion cell axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within surfactant homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tube formation ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor receptor-2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vascular endothelial growth factor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular wound healing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vasodilation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of VEGF-A complex ISO
Inferred from Sequence Orthology
more info
 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
vascular endothelial growth factor A
Names
vascular permeability factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025250.3NP_001020421.2  vascular endothelial growth factor A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. This variant can initiate translation from a non-AUG (CUG) site and also from a downstream, in-frame AUG site. The isoform (1) represented in this RefSeq is translated from the CUG start codon and is the longest isoform.
    Source sequence(s)
    AK031905, BC061468, BQ554097, BY001490, CK626177
    Consensus CDS
    CCDS28816.2
    UniProtKB/Swiss-Prot
    Q00731
    UniProtKB/TrEMBL
    A0A1L1SVG2, F8WH81
    Related
    ENSMUSP00000115883.3, ENSMUST00000142351.9
    Conserved Domains (2) summary
    smart00141
    Location:227309
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:343392
    VEGF_C; VEGF heparin-binding domain
  2. NM_001025257.3NP_001020428.2  vascular endothelial growth factor A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two consecutive in-frame coding exons, compared to variant 1. This variant can initiate translation from a non-AUG (CUG) site and also from a downstream, in-frame AUG site. The isoform (3) represented in this RefSeq is translated from the CUG start codon and it lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK031905, BC061468, BY001490, CK626177
    Consensus CDS
    CCDS28817.2
    UniProtKB/Swiss-Prot
    Q00731
    UniProtKB/TrEMBL
    F6ZE01
    Conserved Domains (1) summary
    smart00141
    Location:227309
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  3. NM_001110266.1NP_001103736.1  vascular endothelial growth factor A isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (4) has a distinct and shorter N-terminus, compared to isoform 1. This variant has transcript support, but the protein is predicted.
    Source sequence(s)
    AC127690, AK031905, BC061468, BQ554097, BU920197
    UniProtKB/Swiss-Prot
    Q00731
    Conserved Domains (2) summary
    pfam14554
    Location:89137
    VEGF_C; VEGF heparin-binding domain
    cl00116
    Location:2754
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
  4. NM_001110267.1NP_001103737.1  vascular endothelial growth factor A isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region and also lacks an in-frame, internal coding exon, compared to variant 1. The resulting isoform (5) has a distinct and shorter N-terminus and also lacks an internal segment, compared to isoform 1. This variant has transcript support, but the protein is predicted.
    Source sequence(s)
    AC127690, AK031905, BC061468, BQ554097, BU920197
    UniProtKB/Swiss-Prot
    Q00731
    Conserved Domains (2) summary
    pfam14554
    Location:60113
    VEGF_C; VEGF heparin-binding domain
    cl00116
    Location:2754
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
  5. NM_001110268.1NP_001103738.1  vascular endothelial growth factor A isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding region and also lacks two consecutive in-frame, internal coding exons, compared to variant 1. The resulting isoform (6) has a distinct and shorter N-terminus and also lacks an internal segment, compared to isoform 1. This variant has transcript support, but the protein is predicted.
    Source sequence(s)
    AC127690, AK031905, BC061468, BQ554097, BU920197
    UniProtKB/Swiss-Prot
    Q00731
    Conserved Domains (1) summary
    cl00116
    Location:2754
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
  6. NM_001287056.1NP_001273985.1  vascular endothelial growth factor A isoform 7 precursor

    See identical proteins and their annotated locations for NP_001273985.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. This variant can initiate translation from a non-AUG (CUG) site and also from a downstream, in-frame AUG. The isoform (7) represented in this RefSeq is translated from the AUG start codon and is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK031905, BC061468, BQ554097, BY001490, CK626177
    UniProtKB/Swiss-Prot
    Q00731, Q6WZL9
    Related
    ENSMUSP00000109148.2, ENSMUST00000113520.8
    Conserved Domains (2) summary
    smart00141
    Location:49131
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:166214
    VEGF_C; VEGF heparin-binding domain
  7. NM_001287057.1NP_001273986.1  vascular endothelial growth factor A isoform Vegf-A precursor

    See identical proteins and their annotated locations for NP_001273986.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal, in-frame coding exon compared to variant 1. It can initiate translation from a non-AUG (CUG) codon, and also from an in-frame, downstream AUG start codon. The isoform (Vegf-A) represented in this RefSeq is derived from the AUG start codon. It has a shorter N-terminus and lacks an internal protein segment compared to isoform 1. This variant also encodes a C-terminally extended isoform (Vegf-Ax), which results from the use of an alternative in-frame, downstream translation termination codon (UAA). Isoform Vegf-Ax is represented in NM_001317041.1.
    Source sequence(s)
    AK031905, BC061468, BY001490, CK626177
    UniProtKB/Swiss-Prot
    Q00731
    Conserved Domains (2) summary
    smart00141
    Location:49131
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:137190
    VEGF_C; VEGF heparin-binding domain
  8. NM_001287058.1NP_001273987.1  vascular endothelial growth factor A isoform 9 precursor

    See identical proteins and their annotated locations for NP_001273987.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two consecutive in-frame coding exons, compared to variant 1. This variant can initiate translation from a non-AUG (CUG) site and also from a downstream, in-frame AUG site. The isoform (9) represented in this RefSeq is translated from the AUG start codon. It has a shorter N-terminus and also lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK031905, BC061468, BY001490, CK626177
    Consensus CDS
    CCDS70817.1
    UniProtKB/Swiss-Prot
    Q00731
    Related
    ENSMUSP00000024747.8, ENSMUST00000024747.14
    Conserved Domains (1) summary
    smart00141
    Location:49131
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
  9. NM_001317041.1NP_001303970.1  vascular endothelial growth factor A isoform Vegf-Ax precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is identical to NM_001287057.1; however, it uses an alternative in-frame, downstream translation termination codon (UAA), which results in a longer, C-terminally extended isoform (Vegf-Ax) compared to isoform Vegf-A. Unlike isoform Vegf-A, which is proangiogenic, Vegf-Ax exhibits antiangiogenic activity. As the upstream UGA stop codon has been shown to be recoded as serine (PMID:24949972), its location in the Vegf-Ax isoform (aa 191) is denoted by an 'S'.
    Source sequence(s)
    AK031905, BC061468, BY001490, CK626177
    UniProtKB/Swiss-Prot
    Q00731
    Conserved Domains (2) summary
    smart00141
    Location:49131
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:142190
    VEGF_C; VEGF heparin-binding domain
  10. NM_009505.4NP_033531.3  vascular endothelial growth factor A isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame, internal coding exon, compared to variant 1. This variant can initiate translation from a non-AUG (CUG) site and also from a downstream, in-frame AUG site. The isoform (2) represented in this RefSeq is translated from the CUG start codon and it lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK031905, BC061468, BY001490, CK626177
    Consensus CDS
    CCDS28818.2
    UniProtKB/Swiss-Prot
    Q00731
    Related
    ENSMUSP00000071575.6, ENSMUST00000071648.12
    Conserved Domains (2) summary
    smart00141
    Location:227309
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam14554
    Location:315368
    VEGF_C; VEGF heparin-binding domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46327919..46343303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)