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Vdac1 voltage-dependent anion channel 1 [ Mus musculus (house mouse) ]

Gene ID: 22333, updated on 8-Feb-2024

Summary

Official Symbol
Vdac1provided by MGI
Official Full Name
voltage-dependent anion channel 1provided by MGI
Primary source
MGI:MGI:106919
See related
Ensembl:ENSMUSG00000020402 AllianceGenome:MGI:106919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vdac5; mVDAC1; mVDAC5
Summary
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Multiple pseudogenes of this gene are found on chromosomes 1, 2, 3, 6, 8, 9, and X. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in heart adult (RPKM 147.4), kidney adult (RPKM 93.8) and 26 other tissues See more
Orthologs
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Genomic context

See Vdac1 in Genome Data Viewer
Location:
11 B1.3; 11 31.86 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (52251905..52280224)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (52360851..52389397)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene S-phase kinase-associated protein 1 Neighboring gene transcription factor 7, T cell specific Neighboring gene STARR-seq mESC enhancer starr_29449 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52096181-52096290 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52097872-52098055 Neighboring gene STARR-seq mESC enhancer starr_29452 Neighboring gene STARR-seq mESC enhancer starr_29453 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52132162-52132271 Neighboring gene predicted gene, 30217 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52152988-52153277 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52154886-52154995 Neighboring gene STARR-positive B cell enhancer ABC_E11479 Neighboring gene STARR-seq mESC enhancer starr_29458 Neighboring gene RIKEN cDNA 9530068E07 gene Neighboring gene STARR-positive B cell enhancer ABC_E3950 Neighboring gene elastin-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ceramide binding ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic anion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oxysterol binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphatidylcholine binding ISO
Inferred from Sequence Orthology
more info
 
enables porin activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated monoatomic anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables voltage-gated monoatomic anion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables voltage-gated monoatomic anion channel activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in monoatomic anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic anion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of calcium import into the mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron-neuron synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of mitochondrial permeability transition pore complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in myelin sheath HDA PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of pore complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
voltage-dependent anion-selective channel protein 1
Names
outer mitochondrial membrane protein porin 1
plasmalemmal porin
voltage-dependent anion-selective channel protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362693.2NP_001349622.1  voltage-dependent anion-selective channel protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645589, AL713864
    Conserved Domains (1) summary
    cd07306
    Location:86364
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
  2. NM_001400986.1NP_001387915.1  voltage-dependent anion-selective channel protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645589, AL713864
    UniProtKB/TrEMBL
    Q3THL7, Q3TIG8, Q3U6K8
  3. NM_001400987.1NP_001387916.1  voltage-dependent anion-selective channel protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645589, AL713864
    UniProtKB/TrEMBL
    Q3THL7, Q3TIG8, Q3U6K8
  4. NM_001400988.1NP_001387917.1  voltage-dependent anion-selective channel protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645589, AL713864
    UniProtKB/TrEMBL
    Q3THL7, Q3TIG8, Q3U6K8
  5. NM_001400989.1NP_001387918.1  voltage-dependent anion-selective channel protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645589, AL713864
    UniProtKB/TrEMBL
    Q3THL7, Q3TIG8, Q3U6K8
  6. NM_011694.7NP_035824.1  voltage-dependent anion-selective channel protein 1 isoform 2

    See identical proteins and their annotated locations for NP_035824.1

    Status: VALIDATED

    Source sequence(s)
    AL645589, AL713864
    Consensus CDS
    CCDS24671.1
    UniProtKB/TrEMBL
    Q3THL7, Q3TIG8, Q3U6K8
    Related
    ENSMUSP00000099819.2, ENSMUST00000102758.8
    Conserved Domains (1) summary
    cd07306
    Location:4282
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    52251905..52280224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)