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VDAC1 voltage dependent anion channel 1 [ Homo sapiens (human) ]

Gene ID: 7416, updated on 8-Jul-2021

Summary

Official Symbol
VDAC1provided by HGNC
Official Full Name
voltage dependent anion channel 1provided by HGNC
Primary source
HGNC:HGNC:12669
See related
Ensembl:ENSG00000213585 MIM:604492
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PORIN; VDAC-1
Summary
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]
Expression
Ubiquitous expression in heart (RPKM 107.1), duodenum (RPKM 94.9) and 25 other tissues See more
Orthologs
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Genomic context

See VDAC1 in Genome Data Viewer
Location:
5q31.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (133971871..134070987, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (133307562..133340666, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene chromosome 5 open reading frame 15 Neighboring gene uncharacterized LOC105379183 Neighboring gene uncharacterized LOC105379185 Neighboring gene Sharpr-MPRA regulatory region 13334 Neighboring gene transcription factor 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with voltage-dependent anion channel 1 (VDAC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with voltage-dependent anion channel 1 (VDAC1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Nef nef HIV-1 Nef downregulates the expression of voltage-dependent anion channel 1 (VDAC1) protein in Nef-transfected SupT1 cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of voltage-dependent anion channel 1 (VDAC1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
vpr The G5 domain of gelsolin inhibits HIV-Vpr-induced T-cell apoptosis by blocking the interaction between Vpr and VDAC PubMed
vpr HIV-1 Vpr interacts with a molecular complex of voltage-dependent anion channel (VDAC) and adenine nucleotide translocator (ANT) by directly binding to ANT resulting in the induction of mitochondrial membrane permeabilization PubMed
retropepsin gag-pol HIV-1 PR cleaves VDAC in a dose-dependent manner in HEK293 cells PubMed
gag-pol HIV-1 PR interacts with mitochondrial proteins VDAC, cytochrome c, TOM22, and Bax in HeLa cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111064

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ceramide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cholesterol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylcholine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables porin activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables voltage-gated anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables voltage-gated anion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables voltage-gated anion channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables voltage-gated anion channel activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in anion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in inorganic anion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in learning IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of calcium import into the mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron-neuron synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pyruvate metabolic process TAS
Traceable Author Statement
more info
 
involved_in regulation of autophagy of mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
part_of mitochondrial permeability transition pore complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of pore complex TAS
Traceable Author Statement
more info
PubMed 
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
voltage-dependent anion-selective channel protein 1
Names
outer mitochondrial membrane protein porin 1
plasmalemmal porin
porin 31HL
porin 31HM
sperm binding protein 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027817.2 RefSeqGene

    Range
    5159..38263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003374.3NP_003365.1  voltage-dependent anion-selective channel protein 1

    See identical proteins and their annotated locations for NP_003365.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC008608, AC025177, AK095989, BC008482, L06132
    Consensus CDS
    CCDS4168.1
    UniProtKB/Swiss-Prot
    P21796
    UniProtKB/TrEMBL
    A0A1L1UHR1, B3KTS5
    Related
    ENSP00000265333.3, ENST00000265333.8
    Conserved Domains (1) summary
    cd07306
    Location:4282
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

RNA

  1. NR_036624.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' exon, compared to variant 1. This variant (3) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF.
    Source sequence(s)
    AC025177, BC008482, DA072915, L06132
  2. NR_036625.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. This variant (2) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF.
    Source sequence(s)
    AC025177, BC008482, BC090042, DA072915, L06132

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    133971871..134070987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009822.1XP_016865311.1  voltage-dependent anion-selective channel protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P21796
    UniProtKB/TrEMBL
    A0A1L1UHR1
    Conserved Domains (1) summary
    cd07306
    Location:4282
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
  2. XM_005272075.3XP_005272132.1  voltage-dependent anion-selective channel protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005272132.1

    UniProtKB/Swiss-Prot
    P21796
    UniProtKB/TrEMBL
    A0A1L1UHR1
    Conserved Domains (1) summary
    cd07306
    Location:4282
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
  3. XM_017009823.1XP_016865312.1  voltage-dependent anion-selective channel protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P21796
    UniProtKB/TrEMBL
    A0A1L1UHR1
    Related
    ENSP00000378484.3, ENST00000395044.7
    Conserved Domains (1) summary
    cd07306
    Location:4282
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
  4. XM_017009821.1XP_016865310.1  voltage-dependent anion-selective channel protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P21796
    UniProtKB/TrEMBL
    A0A1L1UHR1
    Related
    ENSP00000378487.2, ENST00000395047.6
    Conserved Domains (1) summary
    cd07306
    Location:4282
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
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