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FDX1 ferredoxin 1 [ Homo sapiens (human) ]

Gene ID: 2230, updated on 1-Jun-2020

Summary

Official Symbol
FDX1provided by HGNC
Official Full Name
ferredoxin 1provided by HGNC
Primary source
HGNC:HGNC:3638
See related
Ensembl:ENSG00000137714 MIM:103260
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADX; FDX; LOH11CR1D
Summary
This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21. [provided by RefSeq, Aug 2011]
Expression
Biased expression in adrenal (RPKM 178.6), kidney (RPKM 13.5) and 5 other tissues See more
Orthologs

Genomic context

See FDX1 in Genome Data Viewer
Location:
11q22.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (110429948..110464884)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (110300661..110335608)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene radixin Neighboring gene uncharacterized LOC107984385 Neighboring gene long intergenic non-protein coding RNA 2732 Neighboring gene uncharacterized LOC105369487 Neighboring gene Rho GTPase activating protein 20

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
2 iron, 2 sulfur cluster binding IDA
Inferred from Direct Assay
more info
PubMed 
electron transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
iron ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
C21-steroid hormone biosynthetic process TAS
Traceable Author Statement
more info
 
cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 
cellular response to forskolin IEA
Inferred from Electronic Annotation
more info
 
cholesterol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
hormone biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
sterol metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
adrenodoxin, mitochondrial
Names
adrenal ferredoxin
hepatoredoxin
mitochondrial adrenodoxin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004109.5NP_004100.1  adrenodoxin, mitochondrial precursor

    See identical proteins and their annotated locations for NP_004100.1

    Status: REVIEWED

    Source sequence(s)
    AA505582, BC010284, CN333249, DB459133
    Consensus CDS
    CCDS8344.1
    UniProtKB/Swiss-Prot
    P10109
    Related
    ENSP00000260270.2, ENST00000260270.3
    Conserved Domains (1) summary
    cl00159
    Location:67168
    fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    110429948..110464884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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