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Fdx1 ferredoxin 1 [ Mus musculus (house mouse) ]

Gene ID: 14148, updated on 12-May-2024

Summary

Official Symbol
Fdx1provided by MGI
Official Full Name
ferredoxin 1provided by MGI
Primary source
MGI:MGI:103224
See related
Ensembl:ENSMUSG00000032051 AllianceGenome:MGI:103224
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Ferrodoxins are iron-sulfur proteins that facilitate monooxygenase reactions catalyzed by P450 enzymes. The protein encoded by this gene is present in the mitochondrial matrix and transfers electrons from ferredoxin reductase to steroidogenic mitochondrial cytochrome P450 proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Expression
Biased expression in adrenal adult (RPKM 1441.7) and ovary adult (RPKM 344.8) See more
Orthologs
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Genomic context

See Fdx1 in Genome Data Viewer
Location:
9 A5.3; 9 28.62 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (51854323..51874902, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (51943023..51963602, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 20 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:51654007-51654222 Neighboring gene Rho GTPase activating protein 20, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:51674851-51675052 Neighboring gene RIKEN cDNA 4933407I05 gene Neighboring gene predicted gene 6980 Neighboring gene STARR-seq mESC enhancer starr_24133 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene radixin Neighboring gene 40S ribosomal protein S19 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to NADPH-adrenodoxin reductase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to cholesterol monooxygenase (side-chain-cleaving) activity ISO
Inferred from Sequence Orthology
more info
 
enables electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables electron transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in NADPH oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in P450-containing electron transport chain IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to forskolin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial crista ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adrenodoxin, mitochondrial
Names
adrenal ferredoxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301728.1NP_001288657.1  adrenodoxin, mitochondrial isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC140363, AK148115, BB578768, BX516353, D43689
    Consensus CDS
    CCDS90568.1
    UniProtKB/TrEMBL
    A0A1L1STP5, Q3UG56
    Related
    ENSMUSP00000150434.2, ENSMUST00000214013.2
    Conserved Domains (1) summary
    cl00159
    Location:71150
    fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...
  2. NM_007996.2NP_032022.1  adrenodoxin, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_032022.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI050584, BB578768, D43689
    Consensus CDS
    CCDS23178.1
    UniProtKB/Swiss-Prot
    P46656
    UniProtKB/TrEMBL
    Q4FZG2, Q545P3
    Related
    ENSMUSP00000034552.7, ENSMUST00000034552.8
    Conserved Domains (1) summary
    cl00159
    Location:71174
    fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    51854323..51874902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)