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RSPH10B radial spoke head 10 homolog B [ Homo sapiens (human) ]

Gene ID: 222967, updated on 2-Nov-2024

Summary

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Official Symbol
RSPH10Bprovided by HGNC
Official Full Name
radial spoke head 10 homolog Bprovided by HGNC
Primary source
HGNC:HGNC:27362
See related
Ensembl:ENSG00000155026 AllianceGenome:HGNC:27362
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable kinase activity. Predicted to be involved in phosphorylation. Predicted to be located in 9+2 motile cilium. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis (RPKM 16.5) See more
Orthologs
all
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Genomic context

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See RSPH10B in Genome Data Viewer
Location:
7p22.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (5926136..5970851, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (6043889..6088454, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (5965767..6010320, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5871051-5871551 Neighboring gene zinc finger protein 815, pseudogene Neighboring gene Sharpr-MPRA regulatory region 1711 Neighboring gene RNA, 7SL, cytoplasmic 556, pseudogene Neighboring gene oncomodulin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25613 Neighboring gene CCZ1 homolog, vacuolar protein trafficking and biogenesis associated Neighboring gene nonconserved acetylation island sequence 61 enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5987517-5988017 Neighboring gene PMS1 homolog 2, mismatch repair system component Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:6047103-6047794 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25614 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25615 Neighboring gene small nucleolar RNA, H/ACA box 80D Neighboring gene aminoacyl tRNA synthetase complex interacting multifunctional protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Radial spoke proteins of Chlamydomonas flagella. Yang P, et al. J Cell Sci, 2006 Mar 15. PMID 16507594, Free PMC Article
  2. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975
  3. Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma. Mahlokozera T, et al. Nat Commun, 2021 Nov 3. PMID 34732716, Free PMC Article
  4. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Boldt K, et al. Nat Commun, 2016 May 13. PMID 27173435, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of radial spoke head 10 homolog B (RSPH10B) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC50833

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in 9+2 motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
radial spoke head 10 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173565.5 → NP_775836.4  radial spoke head 10 homolog B

    Status: VALIDATED

    Source sequence(s)
    AC004983, AC005995
    Consensus CDS
    CCDS34598.1
    UniProtKB/Swiss-Prot
    A6NMW7, P0C881, Q86ST9, Q8NE68
    Related
    ENSP00000384097.1, ENST00000404406.6
    Conserved Domains (2) summary
    PLN03185
    Location:128 → 335
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    COG4642
    Location:86 → 162
    COG4642; Uncharacterized conserved protein [Function unknown]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    5926136..5970851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515208.4 → XP_011513510.1  radial spoke head 10 homolog B isoform X3

    Conserved Domains (2) summary
    PLN03185
    Location:128 → 318
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    COG4642
    Location:86 → 162
    COG4642; Uncharacterized conserved protein [Function unknown]

  2. XM_011515204.3 → XP_011513506.1  radial spoke head 10 homolog B isoform X1

    See identical proteins and their annotated locations for XP_011513506.1

    Conserved Domains (2) summary
    PLN03185
    Location:128 → 318
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    COG4642
    Location:86 → 162
    COG4642; Uncharacterized conserved protein [Function unknown]

  3. XM_024446691.2 → XP_024302459.1  radial spoke head 10 homolog B isoform X1

    Conserved Domains (2) summary
    PLN03185
    Location:128 → 318
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    COG4642
    Location:86 → 162
    COG4642; Uncharacterized conserved protein [Function unknown]

  4. XM_011515209.4 → XP_011513511.1  radial spoke head 10 homolog B isoform X4

    Conserved Domains (1) summary
    PLN03185
    Location:106 → 320
    PLN03185; phosphatidylinositol phosphate kinase; Provisional

  5. XM_005249659.5 → XP_005249716.1  radial spoke head 10 homolog B isoform X2

    See identical proteins and their annotated locations for XP_005249716.1

    UniProtKB/Swiss-Prot
    A6NMW7, P0C881, Q86ST9, Q8NE68
    Conserved Domains (2) summary
    PLN03185
    Location:128 → 335
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    COG4642
    Location:86 → 162
    COG4642; Uncharacterized conserved protein [Function unknown]

  6. XM_011515207.1 → XP_011513509.1  radial spoke head 10 homolog B isoform X1

    See identical proteins and their annotated locations for XP_011513509.1

    Conserved Domains (2) summary
    PLN03185
    Location:128 → 318
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    COG4642
    Location:86 → 162
    COG4642; Uncharacterized conserved protein [Function unknown]

  7. XM_011515203.1 → XP_011513505.1  radial spoke head 10 homolog B isoform X1

    See identical proteins and their annotated locations for XP_011513505.1

    Conserved Domains (2) summary
    PLN03185
    Location:128 → 318
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    COG4642
    Location:86 → 162
    COG4642; Uncharacterized conserved protein [Function unknown]

  8. XM_047420047.1 → XP_047276003.1  radial spoke head 10 homolog B isoform X7

  9. XM_011515210.1 → XP_011513512.1  radial spoke head 10 homolog B isoform X6

    UniProtKB/TrEMBL
    B3KSE9
    Conserved Domains (1) summary
    PLN03185
    Location:11 → 126
    PLN03185; phosphatidylinositol phosphate kinase; Provisional

  10. XM_017011870.3 → XP_016867359.1  radial spoke head 10 homolog B isoform X5

    Conserved Domains (2) summary
    PLN03185
    Location:128 → 318
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    COG4642
    Location:86 → 162
    COG4642; Uncharacterized conserved protein [Function unknown]

  11. XM_011515212.4 → XP_011513514.1  radial spoke head 10 homolog B isoform X8

    Conserved Domains (2) summary
    PLN03185
    Location:128 → 318
    PLN03185; phosphatidylinositol phosphate kinase; Provisional
    COG4642
    Location:86 → 162
    COG4642; Uncharacterized conserved protein [Function unknown]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    6043889..6088454 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357600.1 → XP_054213575.1  radial spoke head 10 homolog B isoform X4

  2. XM_054357601.1 → XP_054213576.1  radial spoke head 10 homolog B isoform X4

  3. XM_054357596.1 → XP_054213571.1  radial spoke head 10 homolog B isoform X1

  4. XM_054357597.1 → XP_054213572.1  radial spoke head 10 homolog B isoform X1

  5. XM_054357595.1 → XP_054213570.1  radial spoke head 10 homolog B isoform X1

  6. XM_054357598.1 → XP_054213573.1  radial spoke head 10 homolog B isoform X2

  7. XM_054357599.1 → XP_054213574.1  radial spoke head 10 homolog B isoform X3

  8. XM_054357594.1 → XP_054213569.1  radial spoke head 10 homolog B isoform X1

  9. XM_054357603.1 → XP_054213578.1  radial spoke head 10 homolog B isoform X6

  10. XM_054357602.1 → XP_054213577.1  radial spoke head 10 homolog B isoform X5

  11. XM_054357604.1 → XP_054213579.1  radial spoke head 10 homolog B isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C881.1 GenPept UniProtKB/Swiss-Prot:P0C881

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