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Nr1h2 nuclear receptor subfamily 1, group H, member 2 [ Mus musculus (house mouse) ]

Gene ID: 22260, updated on 9-Oct-2021

Summary

Official Symbol
Nr1h2provided by MGI
Official Full Name
nuclear receptor subfamily 1, group H, member 2provided by MGI
Primary source
MGI:MGI:1352463
See related
Ensembl:ENSMUSG00000060601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LX; RI; UR; Un; LXR; Unr; LXRB; NER1; OR-1; Unr2; RIP15; LXRBSV; LXRbeta; AI194859
Expression
Ubiquitous expression in adrenal adult (RPKM 100.3), duodenum adult (RPKM 94.8) and 28 other tissues See more
Orthologs
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Genomic context

See Nr1h2 in Genome Data Viewer
Location:
7; 7 B3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44199040..44204928, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44549616..44553968, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (51805002..51809293, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Spi-B transcription factor (Spi-1/PU.1 related) Neighboring gene polymerase (DNA directed), delta 1, catalytic subunit Neighboring gene microRNA 7053 Neighboring gene napsin A aspartic peptidase Neighboring gene predicted gene 15396 Neighboring gene potassium voltage gated channel, Shaw-related subfamily, member 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables apolipoprotein A-I receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables retinoid X receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular lipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cholesterol storage ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cold-induced thermogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of pinocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylcholine acyl-chain remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cholesterol efflux IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of high-density lipoprotein particle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lipoprotein lipase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pancreatic juice secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of secretion of lysosomal enzymes IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinoic acid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
oxysterols receptor LXR-beta
Names
LXR beta
liver X receptor beta
retinoid X receptor-interacting protein No.15
ubiquitously-expressed nuclear receptor 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285517.1NP_001272446.1  oxysterols receptor LXR-beta isoform a

    See identical proteins and their annotated locations for NP_001272446.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    BC066025, BY197597
    Consensus CDS
    CCDS21211.1
    UniProtKB/Swiss-Prot
    Q60644
    Related
    ENSMUSP00000073188.6, ENSMUST00000073488.12
    Conserved Domains (2) summary
    cd06954
    Location:209444
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cl02596
    Location:58154
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  2. NM_001285518.1NP_001272447.1  oxysterols receptor LXR-beta isoform b

    See identical proteins and their annotated locations for NP_001272447.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3 and 4 both encode the same isoform (b).
    Source sequence(s)
    AK077620, AK134489, BC066025, BQ573162, BY197597
    Consensus CDS
    CCDS71947.1
    UniProtKB/Swiss-Prot
    Q60644
    UniProtKB/TrEMBL
    Q8BP65
    Related
    ENSMUSP00000103543.2, ENSMUST00000107910.8
    Conserved Domains (2) summary
    cd06954
    Location:206441
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cl02596
    Location:55151
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  3. NM_001285519.1NP_001272448.1  oxysterols receptor LXR-beta isoform b

    See identical proteins and their annotated locations for NP_001272448.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3 and 4 both encode the same isoform (b).
    Source sequence(s)
    AK077620, BC066025, BY197597
    Consensus CDS
    CCDS71947.1
    UniProtKB/Swiss-Prot
    Q60644
    UniProtKB/TrEMBL
    Q8BP65
    Related
    ENSMUSP00000103544.2, ENSMUST00000107911.8
    Conserved Domains (2) summary
    cd06954
    Location:206441
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cl02596
    Location:55151
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  4. NM_009473.3NP_033499.1  oxysterols receptor LXR-beta isoform a

    See identical proteins and their annotated locations for NP_033499.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC157653, AK077620, BC066025, BQ573162, BY197597
    Consensus CDS
    CCDS21211.1
    UniProtKB/Swiss-Prot
    Q60644
    UniProtKB/TrEMBL
    Q8BP65
    Related
    ENSMUSP00000126788.2, ENSMUST00000167197.8
    Conserved Domains (2) summary
    cd06954
    Location:209444
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cl02596
    Location:58154
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44199040..44204928 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242378.2XP_030098238.1  oxysterols receptor LXR-beta isoform X2

    Conserved Domains (2) summary
    cd06954
    Location:138373
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cl02596
    Location:183
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  2. XM_006540804.4XP_006540867.1  oxysterols receptor LXR-beta isoform X1

    See identical proteins and their annotated locations for XP_006540867.1

    UniProtKB/Swiss-Prot
    Q60644
    Conserved Domains (2) summary
    cd06954
    Location:209444
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cl02596
    Location:58154
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
  3. XM_017322126.2XP_017177615.1  oxysterols receptor LXR-beta isoform X2

    Conserved Domains (2) summary
    cd06954
    Location:138373
    NR_LBD_LXR; The ligand binding domain of Liver X receptors, a family of nuclear receptors of ligand-activated transcription factors
    cl02596
    Location:183
    NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
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