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Ucn urocortin [ Mus musculus (house mouse) ]

Gene ID: 22226, updated on 26-Sep-2022

Summary

Official Symbol
Ucnprovided by MGI
Official Full Name
urocortinprovided by MGI
Primary source
MGI:MGI:1276123
See related
Ensembl:ENSMUSG00000038676 AllianceGenome:MGI:1276123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ucn1; Mpv17
Summary
This gene encodes a member of the corticotropin-releasing hormone peptide family that participates in coordinating autonomic, endocrine, and behavioral responses to stress. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional hormone. Mice lacking the encoded protein exhibit a heightened anxiety-like behaviors and a significantly reduced acoustic startle response. [provided by RefSeq, Sep 2016]
Expression
Biased expression in heart adult (RPKM 1.5), frontal lobe adult (RPKM 0.4) and 8 other tissues See more
Orthologs
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Genomic context

See Ucn in Genome Data Viewer
Location:
5 B1; 5 17.11 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31295333..31296239, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31137989..31138895, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma Neighboring gene tripartite motif-containing 54 Neighboring gene predicted gene 15469 Neighboring gene MpV17 mitochondrial inner membrane protein Neighboring gene general transcription factor IIIC, polypeptide 2, beta

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Clone Names

  • MGC151325, MGC151327

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables corticotropin-releasing hormone receptor 1 binding ISO
Inferred from Sequence Orthology
more info
 
enables corticotropin-releasing hormone receptor 2 binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in activation of protein kinase A activity ISO
Inferred from Sequence Orthology
more info
 
involved_in aerobic respiration ISO
Inferred from Sequence Orthology
more info
 
involved_in associative learning ISO
Inferred from Sequence Orthology
more info
 
involved_in drinking behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in feeding behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in gastric emptying ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of appetite ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of feeding behavior IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gastric acid secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of necrotic cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in pancreatic juice secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of behavioral fear response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of corticotropin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in prepulse inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in response to auditory stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in response to immobilization stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
involved_in social behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in startle response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in varicosity ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346010.1NP_001332939.1  urocortin preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC109608, BC144891
    Consensus CDS
    CCDS19174.1
    UniProtKB/Swiss-Prot
    P81615, Q14A76
    UniProtKB/TrEMBL
    A0A6P5PTG3, A0A8C6H8M4
    Related
    ENSMUSP00000144390.2, ENSMUST00000201184.2
    Conserved Domains (1) summary
    pfam00473
    Location:83120
    CRF; Corticotropin-releasing factor family
  2. NM_021290.2NP_067265.1  urocortin preproprotein

    See identical proteins and their annotated locations for NP_067265.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC109608
    Consensus CDS
    CCDS19174.1
    UniProtKB/Swiss-Prot
    P81615, Q14A76
    UniProtKB/TrEMBL
    A0A6P5PTG3, A0A8C6H8M4
    Related
    ENSMUSP00000035321.3, ENSMUST00000043475.7
    Conserved Domains (1) summary
    pfam00473
    Location:83120
    CRF; Corticotropin-releasing factor family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31295333..31296239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)