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UCN urocortin [ Homo sapiens (human) ]

Gene ID: 7349, updated on 5-Sep-2021

Summary

Official Symbol
UCNprovided by HGNC
Official Full Name
urocortinprovided by HGNC
Primary source
HGNC:HGNC:12516
See related
Ensembl:ENSG00000163794 MIM:600945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UI; UROC
Summary
This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See UCN in Genome Data Viewer
Location:
2p23.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (27307400..27308445, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27530268..27531313, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Neighboring gene solute carrier family 30 member 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma Neighboring gene tripartite motif containing 54 Neighboring gene Sharpr-MPRA regulatory regions 9483 and 12628 Neighboring gene mitochondrial inner membrane protein MPV17 Neighboring gene general transcription factor IIIC subunit 2 Neighboring gene GTF3C2 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129974, MGC129975

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables corticotropin-releasing hormone receptor 1 binding IEA
Inferred from Electronic Annotation
more info
 
enables corticotropin-releasing hormone receptor 2 binding IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables neuropeptide hormone activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in activation of protein kinase A activity IEA
Inferred from Electronic Annotation
more info
 
involved_in aerobic respiration IEA
Inferred from Electronic Annotation
more info
 
involved_in associative learning IEA
Inferred from Electronic Annotation
more info
 
involved_in drinking behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
involved_in gastric emptying IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of appetite IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell size IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of feeding behavior IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of gastric acid secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of hormone secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of necrotic cell death IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in pancreatic juice secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of calcium ion import IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of collagen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of corticotropin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
involved_in response to auditory stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estradiol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to pain IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
involved_in social behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in startle response IEA
Inferred from Electronic Annotation
more info
 
involved_in vasodilation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon terminus IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in varicosity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
urocortin
Names
prepro-urocortin
urocortin, preproprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033055.1 RefSeqGene

    Range
    4818..5863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003353.4NP_003344.1  urocortin preproprotein

    See identical proteins and their annotated locations for NP_003344.1

    Status: REVIEWED

    Source sequence(s)
    AI857458, BC104470, BU619919
    Consensus CDS
    CCDS1747.1
    UniProtKB/Swiss-Prot
    P55089
    Related
    ENSP00000296099.2, ENST00000296099.2
    Conserved Domains (1) summary
    pfam00473
    Location:85122
    CRF; Corticotropin-releasing factor family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    27307400..27308445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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