U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ubb ubiquitin B [ Mus musculus (house mouse) ]

Gene ID: 22187, updated on 8-Dec-2022

Summary

Official Symbol
Ubbprovided by MGI
Official Full Name
ubiquitin Bprovided by MGI
Primary source
MGI:MGI:98888
See related
Ensembl:ENSMUSG00000019505 AllianceGenome:MGI:98888
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ubc; Ubb2; Uba52; Rps27a
Summary
This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of four direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Pseudogenes of this gene are located on chromosomes 3 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in testis adult (RPKM 2757.3), whole brain E14.5 (RPKM 1808.9) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Ubb in Genome Data Viewer
Location:
11 B2; 11 38.46 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62441997..62444039)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62551171..62553213)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene centromere protein V Neighboring gene predicted gene 12279 Neighboring gene transient receptor potential cation channel, subfamily V, member 2 Neighboring gene RIKEN cDNA 2410006H16 gene Neighboring gene small nucleolar RNA, C/D box 49B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein tag IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adipose tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fat pad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within female gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within female meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hypothalamus gonadotrophin-releasing hormone neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrion transport along microtubule ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neuron projection morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of neuron death ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within seminiferous tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extrinsic component of mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in myelin sheath HDA PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313984.2NP_001300913.1  polyubiquitin-B precursor

    Status: VALIDATED

    Source sequence(s)
    AL596181
    Consensus CDS
    CCDS24826.1
    UniProtKB/Swiss-Prot
    P0CG49
    UniProtKB/TrEMBL
    Q78XY9
    Conserved Domains (1) summary
    cd01803
    Location:77152
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
  2. NM_011664.5NP_035794.1  polyubiquitin-B precursor

    See identical proteins and their annotated locations for NP_035794.1

    Status: VALIDATED

    Source sequence(s)
    AL596181
    Consensus CDS
    CCDS24826.1
    UniProtKB/Swiss-Prot
    P0CG49
    UniProtKB/TrEMBL
    Q78XY9
    Related
    ENSMUSP00000019649.4, ENSMUST00000019649.4
    Conserved Domains (1) summary
    cd01803
    Location:77152
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    62441997..62444039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)