Tyro3 TYRO3 protein tyrosine kinase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tyro3provided by MGI
Official Full Name: TYRO3 protein tyrosine kinase 3provided by MGI
Primary source: MGI:MGI:104294
See related: Ensembl:ENSMUSG00000027298 AllianceGenome:MGI:104294
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Brt; Dtk; Rse; Sky; Tif; Etk-2; TK19-2; tk19-1; etk2/tyro3
Summary: Predicted to enable phosphatidylinositol 3-kinase binding activity; transmembrane receptor protein tyrosine kinase activity; and virus receptor activity. Involved in several processes, including negative regulation of defense response; platelet aggregation; and protein kinase B signaling. Acts upstream of or within several processes, including animal organ development; platelet activation; and substrate adhesion-dependent cell spreading. Predicted to be located in cell surface; endoplasmic reticulum membrane; and nuclear envelope. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; limb; and sensory organ. Orthologous to human TYRO3 (TYRO3 protein tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 29.2), cerebellum adult (RPKM 26.7) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 59.97 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (119628221..119648585)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (119797740..119818104)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TYRO3 agonist as therapy for glomerular disease.
Title: TYRO3 agonist as therapy for glomerular disease.
Regulation of bone homeostasis by MERTK and TYRO3.
Title: Regulation of bone homeostasis by MERTK and TYRO3.
TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis.
Title: TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis.
Tyro3 is a therapeutic target for primary effusion lymphoma.
Title: Kinome profiling of non-Hodgkin lymphoma identifies Tyro3 as a therapeutic target in primary effusion lymphoma.
Axl and Tyro3, but not Mertk, have an important role in platelet activation and thrombus formation
Title: Tyro3, Axl, and Mertk receptors differentially participate in platelet activation and thrombus formation.
Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis.
Title: Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis.
Loss of the Tyro3 receptor correlates with significantly thinner myelin sheaths in both unchallenged mice and during remyelination, particularly in larger caliber axons. Primary effect of Tyro3 is upon the radial expansion of myelin. The loss of Tyro3 leads to a reduction in the number of myelin lamellae on axons.
Title: The TAM receptor TYRO3 is a critical regulator of myelin thickness in the central nervous system.
Disinhibiation of Gas6 binding to Tyro3 due to PGRN reduction results in activation of PKCalpha via PLCgamma, inducing tau phosphorylation at Ser203, mislocalization of tau to dendritic spines, and spine loss.
Title: Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.
shows that Tyro3 has prosurvival roles in the appetite regulatory circuitry and could also provide useful insights towards the development of interventions targeting detrimental weight loss
Title: The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia (anx) mutation.
The findings of this study indicated the critical importance of Tyro3 in potentiating central nervous system myelination
Title: The TAM receptor Tyro3 regulates myelination in the central nervous system.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Gene trapped (1)
Targeted (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tyro3 (e-PCR), detects polymorphism
- UniSTS:257031

Tyro3 (e-PCR), detects polymorphism
- UniSTS:257032

Tyro3 (e-PCR), detects polymorphism
- UniSTS:144711

Tyro3 (e-PCR), detects polymorphism
- UniSTS:144712

Tyro3 (e-PCR), detects polymorphism
- UniSTS:144713

Tyro3 (e-PCR), detects polymorphism
- UniSTS:144714

D15S1348 (e-PCR)
- UniSTS:62677

AI323366 (e-PCR)
- UniSTS:178685

Homology

Homologs of the Tyro3 gene: The Tyro3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 484 organisms have orthologs with human gene Tyro3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic cell clearance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of lymphocyte activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within natural killer cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of innate immune response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of lymphocyte activation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of toll-like receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuropeptide signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovulation cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phagocytosis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within platelet activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet aggregation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of viral life cycle	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein kinase B signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein kinase B signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within secretion by cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within vagina development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: tyrosine-protein kinase receptor TYRO3

Names: receptor tyrosine kinase; tyrosine-protein kinase DTK; tyrosine-protein kinase RSE; tyrosine-protein kinase TIF

NP_001277729.1

EC 2.7.10.1

NP_062265.2

EC 2.7.10.1

XP_006499223.1

EC 2.7.10.1

XP_017172636.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290800.1 → NP_001277729.1 tyrosine-protein kinase receptor TYRO3 isoform B

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains alternative 5' exon structure, and it thus differs in its 5' UTR and initiates translation from an alternative start codon, compared to variant 1. The encoded isoform (B) has a distinct N-terminus and is shorter than isoform A.

Source sequence(s)

AL844896, BC066058

Consensus CDS

CCDS71119.1

UniProtKB/Swiss-Prot

P55144

Related

ENSMUSP00000106410.2, ENSMUST00000110783.8

Conserved Domains (7) summary

smart00408
Location:42 → 107

IGc2; Immunoglobulin C-2 Type

smart00410
Location:35 → 121

IG_like; Immunoglobulin like

cd00063
Location:211 → 303

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05074
Location:494 → 777

PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3

pfam00041
Location:311 → 392

fn3; Fibronectin type III domain

pfam07714
Location:504 → 772

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:127 → 205

Ig; Immunoglobulin domain
NM_019392.2 → NP_062265.2 tyrosine-protein kinase receptor TYRO3 isoform A precursor

See identical proteins and their annotated locations for NP_062265.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (A).

Source sequence(s)

BC066058

Consensus CDS

CCDS16611.1

UniProtKB/Swiss-Prot

P55144, Q78E87

Related

ENSMUSP00000028763.10, ENSMUST00000028763.10

Conserved Domains (7) summary

smart00408
Location:46 → 111

IGc2; Immunoglobulin C-2 Type

smart00410
Location:39 → 125

IG_like; Immunoglobulin like

cd00063
Location:215 → 307

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05074
Location:498 → 781

PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3

pfam00041
Location:315 → 396

fn3; Fibronectin type III domain

pfam07714
Location:508 → 776

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:131 → 209

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

119628221..119648585

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017317147.2 → XP_017172636.2 tyrosine-protein kinase receptor TYRO3 isoform X1

Conserved Domains (5) summary

smart00408
Location:11 → 76

IGc2; Immunoglobulin C-2 Type

cd00063
Location:180 → 272

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05074
Location:463 → 746

PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3

pfam00041
Location:280 → 360

fn3; Fibronectin type III domain

cl11960
Location:96 → 174

Ig; Immunoglobulin domain
XM_006499160.1 → XP_006499223.1 tyrosine-protein kinase receptor TYRO3 isoform X1

Conserved Domains (5) summary

smart00408
Location:11 → 76

IGc2; Immunoglobulin C-2 Type

cd00063
Location:180 → 272

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05074
Location:463 → 746

PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3

pfam00041
Location:280 → 360

fn3; Fibronectin type III domain

cl11960
Location:96 → 174

Ig; Immunoglobulin domain