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TYRO3 TYRO3 protein tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 7301, updated on 7-Dec-2018

Summary

Official Symbol
TYRO3provided by HGNC
Official Full Name
TYRO3 protein tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:12446
See related
Ensembl:ENSG00000092445 MIM:600341
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BYK; Dtk; RSE; Rek; Sky; Tif; Etk-2
Summary
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]
Expression
Broad expression in ovary (RPKM 23.1), brain (RPKM 22.4) and 14 other tissues See more
Orthologs

Genomic context

See TYRO3 in Genome Data Viewer
Location:
15q15.1
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (41559022..41579338)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41851220..41871536)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA polymerase II associated protein 1 Neighboring gene elongin C pseudogene 2 Neighboring gene uncharacterized LOC105370791 Neighboring gene MAX dimerization protein MGA Neighboring gene microRNA 626

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of TYRO3 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16467

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic cell clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
forebrain cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
natural killer cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of lymphocyte activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron cellular homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
ovulation cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase signaling NAS
Non-traceable Author Statement
more info
PubMed 
platelet activation ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
platelet aggregation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
secretion by cell ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
substrate adhesion-dependent cell spreading ISS
Inferred from Sequence or Structural Similarity
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vagina development IEA
Inferred from Electronic Annotation
more info
 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein kinase receptor TYRO3
Names
tyrosine-protein kinase DTK
tyrosine-protein kinase RSE
tyrosine-protein kinase SKY
tyrosine-protein kinase TIF
tyrosine-protein kinase byk
NP_001317193.1
NP_006284.2
XP_016878032.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033013.1 RefSeqGene

    Range
    5001..25317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330264.1NP_001317193.1  tyrosine-protein kinase receptor TYRO3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon, resulting in the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC016134, BC051756
    Consensus CDS
    CCDS81866.1
    UniProtKB/Swiss-Prot
    Q06418
    UniProtKB/TrEMBL
    H0YNK6
    Related
    ENSP00000454050.1, ENST00000559066.5
  2. NM_006293.4NP_006284.2  tyrosine-protein kinase receptor TYRO3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006284.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC016134, BC051756, D17517
    Consensus CDS
    CCDS10080.1
    UniProtKB/Swiss-Prot
    Q06418
    Related
    ENSP00000263798.3, ENST00000263798.7
    Conserved Domains (7) summary
    cd05749
    Location:141220
    Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
    smart00408
    Location:56121
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:49135
    IG_like; Immunoglobulin like
    cd00063
    Location:225317
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05074
    Location:508791
    PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3
    pfam00041
    Location:324406
    fn3; Fibronectin type III domain
    pfam07714
    Location:518786
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    41559022..41579338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022543.2XP_016878032.1  tyrosine-protein kinase receptor TYRO3 isoform X1

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