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Tuba1c tubulin, alpha 1C [ Mus musculus (house mouse) ]

Gene ID: 22146, updated on 11-Apr-2024

Summary

Official Symbol
Tuba1cprovided by MGI
Official Full Name
tubulin, alpha 1Cprovided by MGI
Primary source
MGI:MGI:1095409
See related
Ensembl:ENSMUSG00000043091 AllianceGenome:MGI:1095409
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M[a]6; Tuba6
Summary
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in cytoplasmic microtubule. Orthologous to human TUBA1C (tubulin alpha 1c). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 1657.2), CNS E18 (RPKM 1419.2) and 28 other tissues See more
Orthologs
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Genomic context

Location:
15 F1; 15 55.61 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98927772..98935986)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99029891..99038105)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene predicted gene, 41398 Neighboring gene STARR-positive B cell enhancer ABC_E4148 Neighboring gene STARR-seq mESC enhancer starr_39692 Neighboring gene predicted gene, 41399 Neighboring gene peripherin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tubulin alpha-1C chain
Names
alpha-tubulin 6
alpha-tubulin isotype M-alpha-6
tubulin alpha-6 chain
tubulin, alpha 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009448.4NP_033474.1  tubulin alpha-1C chain

    See identical proteins and their annotated locations for NP_033474.1

    Status: PROVISIONAL

    Source sequence(s)
    AC157610
    Consensus CDS
    CCDS37198.1
    UniProtKB/Swiss-Prot
    P68373
    UniProtKB/TrEMBL
    Q3TIZ0, Q52L87
    Related
    ENSMUSP00000051033.9, ENSMUST00000058914.10
    Conserved Domains (1) summary
    PTZ00335
    Location:1448
    PTZ00335; tubulin alpha chain; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98927772..98935986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)