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TUBA1C tubulin alpha 1c [ Homo sapiens (human) ]

Gene ID: 84790, updated on 5-Jan-2020

Summary

Official Symbol
TUBA1Cprovided by HGNC
Official Full Name
tubulin alpha 1cprovided by HGNC
Primary source
HGNC:HGNC:20768
See related
Ensembl:ENSG00000167553
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TUBA6; bcm948
Expression
Ubiquitous expression in esophagus (RPKM 168.9), bone marrow (RPKM 156.4) and 25 other tissues See more
Orthologs

Genomic context

See TUBA1C in Genome Data Viewer
Location:
12q13.12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (49227926..49274600)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49621715..49667117)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369760 Neighboring gene tubulin alpha 1a Neighboring gene uncharacterized LOC101927267 Neighboring gene peripherin Neighboring gene trophinin associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tubulin, alpha 1c (TUBA1C) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The binding of HIV-1 gp120 to CD4+-permissive cells increases the level of acetylated alpha-tubulin in a CD4-dependent manner; overexpression of Histone Deacetylase 6 (HDAC6) inhibits the acetylation of alpha-tubulin and prevents HIV-1-cell fusion PubMed
Envelope surface glycoprotein gp160, precursor env Treatment of cells with actin-depolymerizing agents or tubulin polymerization inhibitors largely reduces the percentage of cells with capped HIV-1 Gag and Env, indicating an intact actin and tubulin cytoskeleton is required for efficient assembly of HIV-1 PubMed
Envelope transmembrane glycoprotein gp41 env Expression of HIV-1 gp41 cytoplasmic domain reduces acetylated tubulin alpha and interferes with virus-cell fusion PubMed
Pr55(Gag) gag Treatment of cells with actin-depolymerizing agents or tubulin polymerization inhibitors largely reduces the percentage of cells with capped HIV-1 Gag and Env, indicating an intact actin and tubulin cytoskeleton is required for efficient assembly of HIV-1 PubMed
Rev rev HIV-1 Rev interacting protein, tubulin alpha 1c (TUBA1C), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
rev Rev acts to depolymerize microtubules that are formed by tubulin, an effect that is observed during HIV-1 infection PubMed
Tat tat HIV-1 Tat causes a dramatic decrease in alpha-tubulin staining, which indicates disruption of the cytoskeleton organization in human intestinal epithelial cells PubMed
tat HIV-1 Tat (specifically, amino acids 38-72), enhances tubulin polymerization and triggers the mitochondrial pathway to induce T cell apoptosis as shown in vitro by the release of cytochrome c from isolated mitochondria PubMed
tat HIV-1 Tat (amino acids 36-39) binds tubulin alpha/beta dimers and polymerized microtubules leading to the alteration of microtubule dynamics and activation of a mitochondria-dependent apoptotic pathway that is facilitated by the Bcl-2 relative Bim PubMed
integrase gag-pol Co-immunoprecipitation shows interaction of HIV-1 IN with alpha-tubulin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10851, MGC14580

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell division TAS
Traceable Author Statement
more info
PubMed 
cytoskeleton-dependent intracellular transport TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule-based process TAS
Traceable Author Statement
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
vesicle HDA PubMed 

General protein information

Preferred Names
tubulin alpha-1C chain
Names
alpha-tubulin 6
tubulin alpha-6 chain
tubulin, alpha 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303114.1NP_001290043.1  tubulin alpha-1C chain isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC125611, AK293589, AW150119
    Consensus CDS
    CCDS76556.1
    UniProtKB/TrEMBL
    B7Z1K5, F5H5D3
    Related
    ENSP00000443475.1, ENST00000541364.5
    Conserved Domains (2) summary
    PTZ00335
    Location:72518
    PTZ00335; tubulin alpha chain; Provisional
    cd02186
    Location:72505
    alpha_tubulin; The alpha-tubulin family
  2. NM_001303115.2NP_001290044.1  tubulin alpha-1C chain isoform b

    See identical proteins and their annotated locations for NP_001290044.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate exons in the 5' end and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC125611, AK293589, AW150119, DA686435
    UniProtKB/TrEMBL
    B7Z1K5
    Conserved Domains (1) summary
    PTZ00335
    Location:1413
    PTZ00335; tubulin alpha chain; Provisional
  3. NM_001303116.2NP_001290045.1  tubulin alpha-1C chain isoform b

    See identical proteins and their annotated locations for NP_001290045.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' end and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC125611, AK293589, AL539200, AW150119
    UniProtKB/TrEMBL
    B7Z1K5
    Conserved Domains (1) summary
    PTZ00335
    Location:1413
    PTZ00335; tubulin alpha chain; Provisional
  4. NM_001303117.2NP_001290046.1  tubulin alpha-1C chain isoform b

    See identical proteins and their annotated locations for NP_001290046.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' end and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
    Source sequence(s)
    AC125611, AK293589, AW150119, DC366449
    UniProtKB/TrEMBL
    B7Z1K5
    Conserved Domains (1) summary
    PTZ00335
    Location:1413
    PTZ00335; tubulin alpha chain; Provisional
  5. NM_032704.5NP_116093.1  tubulin alpha-1C chain isoform c

    See identical proteins and their annotated locations for NP_116093.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate first exon in place of the first exon of variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC125611, AW150119, BC005946
    Consensus CDS
    CCDS8782.1
    UniProtKB/Swiss-Prot
    Q9BQE3
    Related
    ENSP00000301072.6, ENST00000301072.10
    Conserved Domains (1) summary
    PTZ00335
    Location:1448
    PTZ00335; tubulin alpha chain; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    49227926..49274600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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