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OARD1 O-acyl-ADP-ribose deacylase 1 [ Homo sapiens (human) ]

Gene ID: 221443, updated on 23-Nov-2021

Summary

Official Symbol
OARD1provided by HGNC
Official Full Name
O-acyl-ADP-ribose deacylase 1provided by HGNC
Primary source
HGNC:HGNC:21257
See related
Ensembl:ENSG00000124596 MIM:614393
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TARG1; C6orf130; dJ34B21.3
Summary
The protein encoded by this gene is a deacylase that can convert O-acetyl-ADP-ribose to ADP-ribose and acetate, O-propionyl-ADP-ribose to ADP-ribose and propionate, and O-butyryl-ADP-ribose to ADP-ribose and butyrate. The ADP-ribose product is able to inhibit these reactions through a competitive feedback loop. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in testis (RPKM 36.5), thyroid (RPKM 20.0) and 25 other tissues See more
Orthologs
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Genomic context

See OARD1 in Genome Data Viewer
Location:
6p21.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (41064772..41097787, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41032511..41065526, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene unc-5 family C-terminal like Neighboring gene translocator protein 2 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 2 Neighboring gene nuclear transcription factor Y subunit alpha Neighboring gene ADCY10 pseudogene 1 Neighboring gene uncharacterized LOC105375056 Neighboring gene triggering receptor expressed on myeloid cells like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: UNC5CL

Homology

Clone Names

  • FLJ17636, MGC19570

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP-ribosylglutamate hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables O-acetyl-ADP-ribose deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables purine nucleoside binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of DNA damage IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ADP-ribose glycohydrolase OARD1
Names
O-acetyl-ADP-ribose deacetylase 1
O-acetyl-ADP-ribose deacetylase C6orf130
[Protein ADP-ribosylglutamate] hydrolase OARD1
terminal ADP-ribose protein glycohydrolase 1
NP_001316613.1
NP_001316614.1
NP_001316615.1
NP_001316617.1
NP_001316618.1
NP_001316619.1
NP_001316620.1
NP_001316621.1
NP_001316622.1
NP_001316623.1
NP_001316624.1
NP_001316625.1
NP_659500.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329684.2NP_001316613.1  ADP-ribose glycohydrolase OARD1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-5 all encode the same isoform (a).
    Source sequence(s)
    AL031778
    Consensus CDS
    CCDS34445.1
    UniProtKB/Swiss-Prot
    Q9Y530
    UniProtKB/TrEMBL
    A0A024RCY9
    Related
    ENSP00000420414.1, ENST00000488238.5
    Conserved Domains (1) summary
    cd02901
    Location:13143
    Macro_Poa1p-like; macrodomain, Poa1p-like family
  2. NM_001329685.1NP_001316614.1  ADP-ribose glycohydrolase OARD1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), along with variants 1, 3, 4, and 5, encodes isoform a.
    Source sequence(s)
    AL031778
    Consensus CDS
    CCDS34445.1
    UniProtKB/Swiss-Prot
    Q9Y530
    UniProtKB/TrEMBL
    A0A024RCY9
    Related
    ENSP00000420193.1, ENST00000463088.5
    Conserved Domains (1) summary
    cd02901
    Location:13143
    Macro_Poa1p-like; macrodomain, Poa1p-like family
  3. NM_001329686.2NP_001316615.1  ADP-ribose glycohydrolase OARD1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), along with variants 1, 2, 4, and 5, encodes isoform a.
    Source sequence(s)
    AL031778
    Consensus CDS
    CCDS34445.1
    UniProtKB/Swiss-Prot
    Q9Y530
    UniProtKB/TrEMBL
    A0A024RCY9
    Related
    ENSP00000416829.2, ENST00000424266.7
    Conserved Domains (1) summary
    cd02901
    Location:13143
    Macro_Poa1p-like; macrodomain, Poa1p-like family
  4. NM_001329688.2NP_001316617.1  ADP-ribose glycohydrolase OARD1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), along with variants 1-4, encodes isoform a.
    Source sequence(s)
    AL031778
    Consensus CDS
    CCDS34445.1
    UniProtKB/Swiss-Prot
    Q9Y530
    UniProtKB/TrEMBL
    A0A024RCY9
    Related
    ENSP00000420601.1, ENST00000468811.5
    Conserved Domains (1) summary
    cd02901
    Location:13143
    Macro_Poa1p-like; macrodomain, Poa1p-like family
  5. NM_001329689.2NP_001316618.1  ADP-ribose glycohydrolase OARD1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL031778, BC021579, CX758168
    Consensus CDS
    CCDS87395.1
    UniProtKB/TrEMBL
    C9JXC3, Q05CR9
    Related
    ENSP00000419175.1, ENST00000486443.5
    Conserved Domains (1) summary
    cd02901
    Location:1101
    Macro_Poa1p_like; Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
  6. NM_001329690.2NP_001316619.1  ADP-ribose glycohydrolase OARD1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), along with variants 8-10, encodes isoform c.
    Source sequence(s)
    AL031778
    Consensus CDS
    CCDS87397.1
    UniProtKB/TrEMBL
    C9J5P1
    Related
    ENSP00000418400.1, ENST00000480585.5
    Conserved Domains (1) summary
    cd02901
    Location:1381
    Macro_Poa1p-like; macrodomain, Poa1p-like family
  7. NM_001329691.2NP_001316620.1  ADP-ribose glycohydrolase OARD1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), along with variants 7, 9, and 10, encodes isoform c.
    Source sequence(s)
    AL031778
    Consensus CDS
    CCDS87397.1
    UniProtKB/TrEMBL
    C9J5P1
    Conserved Domains (1) summary
    cd02901
    Location:1381
    Macro_Poa1p-like; macrodomain, Poa1p-like family
  8. NM_001329692.1NP_001316621.1  ADP-ribose glycohydrolase OARD1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), along with variants 7, 8, and 10, encodes isoform c.
    Source sequence(s)
    AL031778, BC021579, DT215423
    Consensus CDS
    CCDS87397.1
    UniProtKB/TrEMBL
    C9J5P1, Q05CR9
    Related
    ENSP00000362247.2, ENST00000373154.6
    Conserved Domains (1) summary
    cd02901
    Location:1381
    Macro_Poa1p-like; macrodomain, Poa1p-like family
  9. NM_001329693.2NP_001316622.1  ADP-ribose glycohydrolase OARD1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), along with variants 7-9, encodes isoform c.
    Source sequence(s)
    AL031778, BC021579, BM353928, DT215423
    Consensus CDS
    CCDS87397.1
    UniProtKB/TrEMBL
    C9J5P1, Q05CR9
    Related
    ENSP00000487484.1, ENST00000628419.2
    Conserved Domains (1) summary
    cd02901
    Location:1381
    Macro_Poa1p-like; macrodomain, Poa1p-like family
  10. NM_001329694.2NP_001316623.1  ADP-ribose glycohydrolase OARD1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), along with variants 12 and 13, encodes isoform d.
    Source sequence(s)
    AL031778
    Consensus CDS
    CCDS87396.1
    UniProtKB/TrEMBL
    C9JA90
    Related
    ENSP00000418098.1, ENST00000482515.5
    Conserved Domains (1) summary
    cl00019
    Location:1361
    Macro_SF; macrodomain superfamily
  11. NM_001329695.1NP_001316624.1  ADP-ribose glycohydrolase OARD1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), along with variants 11 and 13, encodes isoform d.
    Source sequence(s)
    AL031778, BC021579, BE267691, DT215423
    Consensus CDS
    CCDS87396.1
    UniProtKB/TrEMBL
    C9JA90, Q05CR9
    Related
    ENSP00000419875.1, ENST00000464633.5
    Conserved Domains (1) summary
    cl00019
    Location:1361
    Macro_SF; macrodomain superfamily
  12. NM_001329696.2NP_001316625.1  ADP-ribose glycohydrolase OARD1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), along with variants 11 and 12, encodes isoform d.
    Source sequence(s)
    AL031778
    Consensus CDS
    CCDS87396.1
    UniProtKB/TrEMBL
    C9JA90
    Conserved Domains (1) summary
    cl00019
    Location:1361
    Macro_SF; macrodomain superfamily
  13. NM_145063.4NP_659500.1  ADP-ribose glycohydrolase OARD1 isoform a

    See identical proteins and their annotated locations for NP_659500.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), along with variants 1, 2, 3, and 5, encodes isoform a.
    Source sequence(s)
    AL031778, BC011709, BC021579
    Consensus CDS
    CCDS34445.1
    UniProtKB/Swiss-Prot
    Q9Y530
    UniProtKB/TrEMBL
    A0A024RCY9, Q05CR9
    Related
    ENSP00000420484.1, ENST00000479950.5
    Conserved Domains (1) summary
    cd02901
    Location:13143
    Macro_Poa1p-like; macrodomain, Poa1p-like family

RNA

  1. NR_138080.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    BU740294

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    41064772..41097787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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