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UNC5CL unc-5 family C-terminal like [ Homo sapiens (human) ]

Gene ID: 222643, updated on 22-Sep-2022

Summary

Official Symbol
UNC5CLprovided by HGNC
Official Full Name
unc-5 family C-terminal likeprovided by HGNC
Primary source
HGNC:HGNC:21203
See related
Ensembl:ENSG00000124602 MIM:617464; AllianceGenome:HGNC:21203
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZUD; MUXA
Summary
Enables peptidase activity. Acts upstream of or within positive regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of JNK cascade. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum (RPKM 20.3), small intestine (RPKM 16.3) and 6 other tissues See more
Orthologs
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Genomic context

See UNC5CL in Genome Data Viewer
Location:
6p21.1
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (41026895..41039221, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (40855459..40867785, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (40994634..41006960, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929555 Neighboring gene Sharpr-MPRA regulatory region 12741 Neighboring gene Sharpr-MPRA regulatory region 875 Neighboring gene translocator protein 2 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 2 Neighboring gene O-acyl-ADP-ribose deacylase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: OARD1

Homology

Clone Names

  • MGC34763

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables netrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
UNC5C-like protein
Names
ZU5 and death domain containing
protein unc-5 homolog C-like
unc-5 homolog C-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173561.3NP_775832.2  UNC5C-like protein

    See identical proteins and their annotated locations for NP_775832.2

    Status: VALIDATED

    Source sequence(s)
    AI791395, AL031778, BC035284, BM312066
    Consensus CDS
    CCDS4847.1
    UniProtKB/Swiss-Prot
    Q5TGU1, Q8IV45
    UniProtKB/TrEMBL
    H8YHX0
    Related
    ENSP00000244565.3, ENST00000244565.8
    Conserved Domains (2) summary
    pfam00791
    Location:103192
    ZU5; ZU5 domain
    cl14633
    Location:408488
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    41026895..41039221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    40855459..40867785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)