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FCGR3A Fc fragment of IgG receptor IIIa [ Homo sapiens (human) ]

Gene ID: 2214, updated on 18-Mar-2020

Summary

Official Symbol
FCGR3Aprovided by HGNC
Official Full Name
Fc fragment of IgG receptor IIIaprovided by HGNC
Primary source
HGNC:HGNC:3619
See related
Ensembl:ENSG00000203747 MIM:146740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA
Summary
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in spleen (RPKM 154.1), lung (RPKM 70.6) and 10 other tissues See more
Orthologs

Genomic context

See FCGR3A in Genome Data Viewer
Location:
1q23.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161541759..161550737, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161511549..161520413, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S23 pseudogene 10 Neighboring gene tRNA-Asn (anticodon GTT) 1-1 Neighboring gene Fc fragment of IgG receptor IIc (gene/pseudogene) Neighboring gene heat shock protein family A (Hsp70) member 7 (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Immunodeficiency 20
MedGen: C3810342 OMIM: 615707 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 is vertically transmitted more readily by mothers who are heterozygous for high-affinity and low-affinity FCGR3A PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env NK cells that respond with IFN-gamma and TNF-alpha cytokine production to HIV-1 gp120 peptides have reduced CD16 and NKp46 expression and have increased levels of CD57 PubMed
env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
Nef nef Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Nef may antagonize restriction activity of FCGR3A against production of infectious wild-type HIV-1 PubMed
Tat tat HIV-1 Tat upregulates the expression of CCR2, CD16, and TLR4 in monocyte-derived macrophages PubMed
tat HIV-1 Tat inhibits the rise in intracellular free calcium concentration in Natural Killer (NK) cells upon cross-linking of the adhesion molecule CD11a and the activation molecule CD16, indicating Tat is involved in the impairment of NK cell function PubMed
Vpr vpr Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Vpu may antagonize restriction activity of FCGR3A against production of infectious wild-type HIV-1 PubMed
Vpu vpu The ability of HIV-1 Vpu to antagonize tetherin is important for the antibody opsonization of HIV-infected cells, which in turn increases FCGRIII (CD16) signaling PubMed
vpu Production of infectious triple deletion vpr/vpu/nef HIV-1 mutant is suppressed, indicating that Vpu may antagonize restriction activity of FCGR3A against production of infectious wild-type HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
IgG binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
low affinity immunoglobulin gamma Fc region receptor III-A
Names
CD16a antigen
Fc fragment of IgG, low affinity III, receptor for (CD16)
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Fc gamma receptor III-A
Fc-gamma RIII-alpha
Fc-gamma receptor III-2 (CD 16)
Fc-gamma receptor IIIb (CD16)
FcgammaRIIIA
igG Fc receptor III-2
immunoglobulin G Fc receptor III
low affinity immunoglobulin gamma receptor III-a Fc fragment
neutrophil-specific antigen NA

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009066.1 RefSeqGene

    Range
    5001..13865
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_60

mRNA and Protein(s)

  1. NM_000569.8NP_000560.7  low affinity immunoglobulin gamma Fc region receptor III-A isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) retains an intron in its 5' UTR and 5' coding region compared to variant 3.Variants 1, 3, 4 and 6 encode the same isoform (c).compared to isoform c.
    Source sequence(s)
    AK302126, BC033678
    Consensus CDS
    CCDS1232.2
    Related
    ENSP00000356946.4, ENST00000367969.8
  2. NM_001127592.2NP_001121064.2  low affinity immunoglobulin gamma Fc region receptor III-A isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) retains an intron in its 5' UTR and 5' coding region, and uses an alternate in-frame splice site in its 5' coding region compared to variant 3. The encoded isoform (2) is longer than isoform c. This isoform (b) lacks a predicted signal peptide compared to isoform c.
    Source sequence(s)
    AK302126, BC036723, DA944383, M24853
    UniProtKB/Swiss-Prot
    P08637
    Related
    ENSP00000410180.2, ENST00000426740.6
  3. NM_001127593.1NP_001121065.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform c precursor

    See identical proteins and their annotated locations for NP_001121065.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform c. Variants 3, 4 and 6 encode the same isoform (c).
    Source sequence(s)
    AL590385, BC036723, DA957430, M24853
    Consensus CDS
    CCDS44266.1
    UniProtKB/Swiss-Prot
    P08637
    Related
    ENSP00000416607.1, ENST00000436743.5
    Conserved Domains (3) summary
    cd05752
    Location:26104
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:108190
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:32104
    IG_like; Immunoglobulin like
  4. NM_001127595.2NP_001121067.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform c precursor

    See identical proteins and their annotated locations for NP_001121067.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 3, 4 and 6 encode the same isoform (c).
    Source sequence(s)
    BC036723, DA933259, DA957430, M24853
    Consensus CDS
    CCDS44266.1
    UniProtKB/Swiss-Prot
    P08637
    Related
    ENSP00000356944.3, ENST00000367967.7
    Conserved Domains (3) summary
    cd05752
    Location:26104
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:108190
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:32104
    IG_like; Immunoglobulin like
  5. NM_001127596.2NP_001121068.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform d precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region compared to variant 3. The encoded isoform (d) is shorter than isoform c.
    Source sequence(s)
    BC036723, DA674960, DA957430, M24853
    UniProtKB/Swiss-Prot
    P08637
    Conserved Domains (2) summary
    cd05752
    Location:25103
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:107189
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
  6. NM_001329120.1NP_001316049.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 3. Variants 3, 4 and 6 encode the same isoform (c).
    Source sequence(s)
    AL590385, BC036723
    Consensus CDS
    CCDS44266.1
    UniProtKB/Swiss-Prot
    P08637
    Conserved Domains (3) summary
    cd05752
    Location:26104
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:108190
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:32104
    IG_like; Immunoglobulin like
  7. NM_001329122.1NP_001316051.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) retains an intron in its 5' UTR and 5' coding region, and lacks an alternate in-frame exon in its 3' coding region compared to variant 3. The encoded isoform is longer than isoform c. This isoform (e) lacks a predicted signal peptide compared to isoform c.
    Source sequence(s)
    AL590385, BC036723

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    161541759..161550737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454064.1XP_024309832.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform X1

    Conserved Domains (2) summary
    cd05752
    Location:25103
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:107189
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
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