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Ttk Ttk protein kinase [ Mus musculus (house mouse) ]

Gene ID: 22137, updated on 2-Nov-2024

Summary

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Official Symbol
Ttkprovided by MGI
Official Full Name
Ttk protein kinaseprovided by MGI
Primary source
MGI:MGI:1194921
See related
Ensembl:ENSMUSG00000038379 AllianceGenome:MGI:1194921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PYT; esk; Esk1; Mps1
Summary
Enables identical protein binding activity; kinetochore binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in mitotic spindle assembly checkpoint signaling. Acts upstream of or within several processes, including meiotic spindle assembly checkpoint signaling; protein localization to organelle; and protein phosphorylation. Located in kinetochore. Is expressed in several structures, including brain; lung; and metanephros. Orthologous to human TTK (TTK protein kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 9.2), placenta adult (RPKM 7.3) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Ttk in Genome Data Viewer
Location:
9 E2; 9 45.61 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (83716704..83754442)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (83834651..83872390)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24797 Neighboring gene predicted gene, 39386 Neighboring gene ELOVL fatty acid elongase 4 Neighboring gene STARR-positive B cell enhancer mm9_chr9:83701190-83701491 Neighboring gene STARR-positive B cell enhancer ABC_E10570 Neighboring gene STARR-seq mESC enhancer starr_24799 Neighboring gene predicted gene, 39387 Neighboring gene STARR-positive B cell enhancer mm9_chr9:83818551-83818852 Neighboring gene predicted gene, 36278

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The essential roles of Mps1 in spermatogenesis and fertility in mice. Fang Q, et al. Cell Death Dis, 2021 May 24. PMID 34031364, Free PMC Article
  2. Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms. Douville EM, et al. Mol Cell Biol, 1992 Jun. PMID 1375325, Free PMC Article
  3. The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I. Zhou C, et al. Sci Adv, 2020 Apr. PMID 32284991, Free PMC Article
  4. High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells. Daniel J, et al. Proc Natl Acad Sci U S A, 2011 Mar 29. PMID 21402910, Free PMC Article
  5. Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest. Touati SA, et al. Nat Commun, 2015 Apr 21. PMID 25897860, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The essential roles of Mps1 in spermatogenesis and fertility in mice.
    Title: The essential roles of Mps1 in spermatogenesis and fertility in mice.
  2. using in vitro dephosphorylation assays, we demonstrate that Mastl promotes persistent MPS1 phosphorylation by inhibiting PP2A/B55-mediated MPS1 dephosphorylation rather than affecting Cdk1 kinase activity. Our findings establish a key regulatory function of the Greatwall kinase/Mastl - PP2A/B55 pathway in preventing premature SAC silencing
    Title: Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint.
  3. In a sensitized p53(+/-) background, Mps1(DK/DK) mice suffered from rapid-onset acute lymphoblastic lymphoma.
    Title: Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.
  4. Mps1 is essential for meiosis I in mouse. Kinetochore localization of Mps1 is required for correct timing of prometaphase, to prevent precocious APC/C activation, for SAC control, correct aurora C (Aurkc) localization and chromosome alignment.
    Title: Mps1 at kinetochores is essential for female mouse meiosis I.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinetochore binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine/tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine/tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within female meiosis chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic prometaphase I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within meiotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein localization to chromosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization to meiotic spindle midzone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in repair of mitotic kinetochore microtubule attachment defect IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual specificity protein kinase TTK
NP_001103735.1
NP_001271201.1
NP_033471.2
XP_006511121.1
XP_006511123.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110265.2 → NP_001103735.1  dual specificity protein kinase TTK isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes a 3' terminal exon that extends beyond a splice site used in variant 1 and results in a distinct 3' coding region and 3' UTR compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC124011
    UniProtKB/TrEMBL
    Q8BY97
    Related
    ENSMUST00000188445.7
    Conserved Domains (3) summary
    cd14131
    Location:496 → 764
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    sd00006
    Location:105 → 134
    TPR; TPR repeat [structural motif]
    pfam00069
    Location:498 → 764
    Pkinase; Protein kinase domain

  2. NM_001284272.2 → NP_001271201.1  dual specificity protein kinase TTK isoform 3

    See identical proteins and their annotated locations for NP_001271201.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon and uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC124011
    Consensus CDS
    CCDS81044.1
    UniProtKB/TrEMBL
    Q3TPW2, Q6PD96
    Related
    ENSMUSP00000139956.2, ENSMUST00000185913.7
    Conserved Domains (3) summary
    sd00006
    Location:105 → 134
    TPR; TPR repeat [structural motif]
    pfam00069
    Location:498 → 707
    Pkinase; Protein kinase domain
    cl21453
    Location:496 → 707
    PKc_like; Protein Kinases, catalytic domain

  3. NM_009445.3 → NP_033471.2  dual specificity protein kinase TTK isoform 1

    See identical proteins and their annotated locations for NP_033471.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AC124011
    Consensus CDS
    CCDS52874.1
    UniProtKB/TrEMBL
    Q6PD96
    Related
    ENSMUSP00000064839.8, ENSMUST00000070326.14
    Conserved Domains (3) summary
    cd14131
    Location:496 → 764
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    sd00006
    Location:105 → 134
    TPR; TPR repeat [structural motif]
    pfam00069
    Location:498 → 764
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    83716704..83754442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511060.2 → XP_006511123.1  dual specificity protein kinase TTK isoform X2

    UniProtKB/TrEMBL
    Q8BY97
    Conserved Domains (2) summary
    sd00006
    Location:143 → 172
    TPR; TPR repeat [structural motif]
    cl21453
    Location:535 → 722
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006511058.1 → XP_006511121.1  dual specificity protein kinase TTK isoform X1

    UniProtKB/TrEMBL
    Q6PD96
    Conserved Domains (2) summary
    cd14131
    Location:535 → 803
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    sd00006
    Location:143 → 172
    TPR; TPR repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35761.1 GenPept UniProtKB/Swiss-Prot:P35761

Gene LinkOut

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