TTK TTK protein kinase [Homo sapiens (human)] - Gene

Summary

Official Symbol: TTKprovided by HGNC
Official Full Name: TTK protein kinaseprovided by HGNC
Primary source: HGNC:HGNC:12401
See related: Ensembl:ENSG00000112742 MIM:604092; AllianceGenome:HGNC:12401
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ESK; PYT; CT96; MPH1; MPS1; MPS1L1
Summary: This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Expression: Biased expression in testis (RPKM 13.6), bone marrow (RPKM 6.1) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q14.1

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (80004649..80042527)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (81213044..81250924)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (80714366..80752244)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TTK predicts triple positive breast cancer prognosis and regulates tumor proliferation and invasion.
Title: TTK predicts triple positive breast cancer prognosis and regulates tumor proliferation and invasion.
Hsp90 regulates the tumorigenic function of tyrosine protein kinase in osteosarcoma.
Title: Hsp90 regulates the tumorigenic function of tyrosine protein kinase in osteosarcoma.
Identification of hub genes associated with prognosis, diagnosis, immune infiltration and therapeutic drug in liver cancer by integrated analysis.
Title: Identification of hub genes associated with prognosis, diagnosis, immune infiltration and therapeutic drug in liver cancer by integrated analysis.
Frequent expression of a novel cancer testis antigen, protein kinase human monopolar spindle 1 (hMps1/TTK) in human urinary bladder transitional cell carcinoma.
Title: Frequent expression of a novel cancer testis antigen, protein kinase human monopolar spindle 1 (hMps1/TTK) in human urinary bladder transitional cell carcinoma.
Overexpressed MPS-1 contributes to endometrioma development through the NF-kappaB signaling pathway.
Title: Overexpressed MPS-1 contributes to endometrioma development through the NF-κB signaling pathway.
TTK (threonine tyrosine kinase) regulates the malignant behaviors of cancer cells and is regulated by microRNA-582-5p in ovarian cancer.
Title: TTK (threonine tyrosine kinase) regulates the malignant behaviors of cancer cells and is regulated by microRNA-582-5p in ovarian cancer.
CENPE, PRC1, TTK, and PLK4 May Play Crucial Roles in the Osteosarcoma Progression.
Title: CENPE, PRC1, TTK, and PLK4 May Play Crucial Roles in the Osteosarcoma Progression.
TTK regulates proliferation and apoptosis of gastric cancer cells through the Akt-mTOR pathway.
Title: TTK regulates proliferation and apoptosis of gastric cancer cells through the Akt-mTOR pathway.
Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers.
Title: Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers.
Mps1 dimerization and multisite interactions with Ndc80 complex enable responsive spindle assembly checkpoint signaling.
Title: Mps1 dimerization and multisite interactions with Ndc80 complex enable responsive spindle assembly checkpoint signaling.

Submit: New GeneRIF Correction See all GeneRIFs (122)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH1535 (e-PCR)
- UniSTS:88910

D6S2407 (e-PCR)
- UniSTS:29430

Homology

Homologs of the TTK gene: The TTK gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 435 organisms have orthologs with human gene TTK
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables kinetochore binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein serine/threonine/tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in chromosome separation	IEA Inferred from Electronic Annotation more info
involved_in female meiosis chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in meiotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in mitotic spindle organization	TAS Traceable Author Statement more info	PubMed
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in peptidyl-threonine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in protein autophosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein localization to kinetochore	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein localization to meiotic spindle midzone	IEA Inferred from Electronic Annotation more info
involved_in spindle organization	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in membrane	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in spindle	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: dual specificity protein kinase TTK

Names: cancer/testis antigen 96; monopolar spindle 1 kinase; monopolar spindle 1-like 1; phosphotyrosine picked threonine kinase; phosphotyrosine picked threonine-protein kinase

NP_001160163.1

EC 2.7.12.1

NP_003309.2

EC 2.7.12.1

XP_011534401.1

EC 2.7.12.1

XP_011534402.1

EC 2.7.12.1

XP_016866731.1

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166691.2 → NP_001160163.1 dual specificity protein kinase TTK isoform 2

See identical proteins and their annotated locations for NP_001160163.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses alternate in-frame splice sites in the 5' UTR and in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AK292460, AL133475, AU154042

Consensus CDS

CCDS55040.1

UniProtKB/Swiss-Prot

P33981

Related

ENSP00000230510.3, ENST00000230510.7

Conserved Domains (2) summary

cd14131
Location:522 → 790

PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

pfam00069
Location:524 → 790

Pkinase; Protein kinase domain
NM_003318.5 → NP_003309.2 dual specificity protein kinase TTK isoform 1

See identical proteins and their annotated locations for NP_003309.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).

Source sequence(s)

AK315696, AU154042, DA853919

Consensus CDS

CCDS4993.1

UniProtKB/Swiss-Prot

P33981

Related

ENSP00000358813.2, ENST00000369798.7

Conserved Domains (1) summary

cd14131
Location:523 → 791

PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

80004649..80042527

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011536099.4 → XP_011534401.1 dual specificity protein kinase TTK isoform X1

See identical proteins and their annotated locations for XP_011534401.1

UniProtKB/Swiss-Prot

P33981

Conserved Domains (1) summary

cd14131
Location:523 → 791

PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
XM_011536100.4 → XP_011534402.1 dual specificity protein kinase TTK isoform X2

See identical proteins and their annotated locations for XP_011534402.1

UniProtKB/Swiss-Prot

P33981

Related

ENSP00000422936.1, ENST00000509894.5

Conserved Domains (2) summary

cd14131
Location:522 → 790

PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

pfam00069
Location:524 → 790

Pkinase; Protein kinase domain
XM_017011242.3 → XP_016866731.1 dual specificity protein kinase TTK isoform X3