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TTK TTK protein kinase [ Homo sapiens (human) ]

Gene ID: 7272, updated on 16-Sep-2019

Summary

Official Symbol
TTKprovided by HGNC
Official Full Name
TTK protein kinaseprovided by HGNC
Primary source
HGNC:HGNC:12401
See related
Ensembl:ENSG00000112742 MIM:604092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESK; PYT; CT96; MPH1; MPS1; MPS1L1
Summary
This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
Expression
Biased expression in testis (RPKM 13.6), bone marrow (RPKM 6.1) and 10 other tissues See more
Orthologs

Genomic context

See TTK in Genome Data Viewer
Location:
6q14.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (80004147..80042651)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (80714322..80752244)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 63 Neighboring gene ribosomal protein L35a pseudogene 18 Neighboring gene Rho GTPase activating protein 21 pseudogene Neighboring gene adenylate kinase 4 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Cell cycle, organism-specific biosystem (from KEGG)
    Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle, conserved biosystem (from KEGG)
    Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Retinoblastoma (RB) in Cancer, organism-specific biosystem (from WikiPathways)
    Retinoblastoma (RB) in Cancer, organism-specific biosystemDescribes the role of retinoblastoma (RB) gene in cancer.

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38280

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinetochore binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine/tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome separation IEA
Inferred from Electronic Annotation
more info
 
female meiosis chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
meiotic spindle assembly checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle assembly checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle organization TAS
Traceable Author Statement
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein localization to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to meiotic spindle midzone IEA
Inferred from Electronic Annotation
more info
 
spindle organization TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dual specificity protein kinase TTK
Names
cancer/testis antigen 96
monopolar spindle 1 kinase
monopolar spindle 1-like 1
phosphotyrosine picked threonine kinase
phosphotyrosine picked threonine-protein kinase
NP_001160163.1
NP_003309.2
XP_011534401.1
XP_011534402.1
XP_016866731.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166691.1NP_001160163.1  dual specificity protein kinase TTK isoform 2

    See identical proteins and their annotated locations for NP_001160163.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses alternate in-frame splice sites in the 5' UTR and in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK292460, AL133475, AU154042, DA853919
    Consensus CDS
    CCDS55040.1
    UniProtKB/Swiss-Prot
    P33981
    Related
    ENSP00000230510.3, ENST00000230510.7
    Conserved Domains (2) summary
    cd14131
    Location:522790
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    pfam00069
    Location:524790
    Pkinase; Protein kinase domain
  2. NM_003318.5NP_003309.2  dual specificity protein kinase TTK isoform 1

    See identical proteins and their annotated locations for NP_003309.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK315696, AU154042, DA853919
    Consensus CDS
    CCDS4993.1
    UniProtKB/Swiss-Prot
    P33981
    Related
    ENSP00000358813.2, ENST00000369798.7
    Conserved Domains (1) summary
    cd14131
    Location:523791
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    80004147..80042651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536099.3XP_011534401.1  dual specificity protein kinase TTK isoform X1

    See identical proteins and their annotated locations for XP_011534401.1

    UniProtKB/Swiss-Prot
    P33981
    Conserved Domains (1) summary
    cd14131
    Location:523791
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
  2. XM_017011242.2XP_016866731.1  dual specificity protein kinase TTK isoform X3

  3. XM_011536100.3XP_011534402.1  dual specificity protein kinase TTK isoform X2

    See identical proteins and their annotated locations for XP_011534402.1

    UniProtKB/Swiss-Prot
    P33981
    Related
    ENSP00000422936.1, ENST00000509894.5
    Conserved Domains (2) summary
    cd14131
    Location:522790
    PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    pfam00069
    Location:524790
    Pkinase; Protein kinase domain
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