FCGR2B Fc fragment of IgG receptor IIb [Homo sapiens (human)] - Gene

Summary

Official Symbol: FCGR2Bprovided by HGNC
Official Full Name: Fc fragment of IgG receptor IIbprovided by HGNC
Primary source: HGNC:HGNC:3618
See related: Ensembl:ENSG00000072694 MIM:604590
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD32; FCG2; CD32B; FCGR2; IGFR2; FCGR2C; FcRII-c
Summary: The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Expression: Biased expression in placenta (RPKM 92.9), appendix (RPKM 9.6) and 6 other tissues See more
Orthologs: all

Genomic context

Location:: 1q23.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109.20200522	current	GRCh38.p13 (GCF_000001405.39)	1	NC_000001.11 (161647243..161678654)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (161632905..161648444)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study in syngeneic mouse glioblastoma (GBM) model, human GBM samples, and cancer-immune cell co-culture revealed that IGFBP2-promoted immunosuppression associated with its induction of the mesenchymal feature of GBM cells and the inhibitory phosphorylated FcgammaRIIB of GBM exposed immune cells. Inhibition of IGFBP2 relieved immunosuppression by increasing CD8+ T and CD19+ B cells and decreasing CD163+ M2 macrophages.
Title: IGFBP2 promotes immunosuppression associated with its mesenchymal induction and FcγRIIB phosphorylation in glioblastoma.
The authors identified a subset of effector CD8(+) T cells that expressed the inhibitory fragment crystallizable receptor FcgammaRIIB following activation and multiple rounds of division. these findings demonstrate a cell-intrinsic coinhibitory function of FcgammaRIIB in regulating CD8(+) T cell immunity.
Title: Signaling through the Inhibitory Fc Receptor FcγRIIB Induces CD8<sup>+</sup> T Cell Apoptosis to Limit T Cell Immunity.
I232T substitution reduces in situ two-dimensional binding affinities and association rates of FcgammaRIIB to interact with its ligands, IgG1, IgG2 and IgG3 by three to four folds. This allosteric regulation by a single nucleotide polymorphism provides an intrinsic molecular mechanism for the functional loss of FcgammaRIIB-I232T in systemic lupus erythematosus patients.
Title: FcγRIIB-I232T polymorphic change allosterically suppresses ligand binding.
Graves' disease patients had a reduced CD32 expression on monocytes.
Title: Decreased expression of FcγRII in active Graves' disease patients.
Study shows that TOM1 regulates neuronal accumulation of amyloid-beta oligomers by FcgammaRIIb2 variant in Alzheimer's Disease (AD). Study provides a molecular mechanism responsible for neuronal uptake of pathogenic Abeta found in AD.
Title: TOM1 Regulates Neuronal Accumulation of Amyloid-β Oligomers by FcγRIIb2 Variant in Alzheimer's Disease.
REVIEW: deeper understanding of the importance of the TM domain in mediating the inhibitory function of FcgammaRIIB and insights to a new therapeutic target for the associated diseases
Title: Transmembrane domain dependent inhibitory function of FcγRIIB.
FcgammaRIIB expressed in neurons functions as a receptor for alpha-syn fibrils and mediates cell-to-cell transmission of alpha-syn. SHP-1 and 2 are activated downstream by alpha-syn fibrils through FcgammaRIIB and play an important role in cell-to-cell transmission of alpha-syn.
Title: Prion-like Propagation of α-Synuclein Is Regulated by the FcγRIIB-SHP-1/2 Signaling Pathway in Neurons.
The expression levels of human FcgammaRIIB but not FcgammaRIIA were negatively correlated with serum levels of IgE in human asthma patients.
Title: FcγRIIIA Negatively Impacts Humoral Immune Responses but Not Overall Lung Inflammation in an Ovalbumin-Induced Allergic Asthma Mouse Model.
Data show that patients with low FcgammaRIIb (CD32b) expression required therapy earlier than those with high FcgammaRIIb expression.
Title: FcγRIIb expression in early stage chronic lymphocytic leukemia.
FcgammaRIIA and FcgammaRIIB both demonstrated increased methylation levels in Kawasaki disease (KD) patients that underwent IVIG treatment. FcgammaRIIA expression influenced the IVIG treatment response of KD patients. The FcgammaRIIA/IIB mRNA expression ratio was greater in KD patients with coronary artery lesion formation.
Title: The effect of FcγRIIA and FcγRIIB on coronary artery lesion formation and intravenous immunoglobulin treatment responses in children with Kawasaki disease.

Submit: New GeneRIF Correction See all GeneRIFs (145)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Susceptibility to malaria MedGen: C1970028 OMIM: 611162 GeneReviews: Not available	Compare labs
Systemic lupus erythematosus MedGen: C0024141 OMIM: 152700 GeneReviews: Not available	Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study identifies multiple loci influencing human serum metabolite levels. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120	PubMed
Nef	nef	HIV-1 Nef downregulates Fc-gamma Receptor II in human monocytes/macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH66834 (e-PCR)
- UniSTS:29229

G06355 (e-PCR)
- UniSTS:73835

RH69121 (e-PCR)
- UniSTS:32170

PMC26659P1 (e-PCR)
- UniSTS:272343

GDB:190031 (e-PCR)
- UniSTS:155610

RH11110 (e-PCR)
- UniSTS:68838

Homology

Homologs of the FCGR2B gene: The FCGR2B gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.
Orthologs from Annotation Pipeline: 80 organisms have orthologs with human gene FCGR2B
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
IgG binding	IDA Inferred from Direct Assay more info	PubMed
amyloid-beta binding	IPI Inferred from Physical Interaction more info	PubMed
amyloid-beta binding	TAS Traceable Author Statement more info	PubMed
low-affinity IgG receptor activity	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis	IDA Inferred from Direct Assay more info	PubMed
antigen processing and presentation of exogenous peptide antigen via MHC class II	ISS Inferred from Sequence or Structural Similarity more info	PubMed
cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cellular response to amyloid-beta	ISS Inferred from Sequence or Structural Similarity more info	PubMed
cellular response to molecule of bacterial origin	ISS Inferred from Sequence or Structural Similarity more info	PubMed
cerebellum development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
defense response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
follicular B cell differentiation	TAS Traceable Author Statement more info	PubMed
follicular dendritic cell activation	TAS Traceable Author Statement more info	PubMed
immune complex clearance by monocytes and macrophages	TAS Traceable Author Statement more info	PubMed
immune response	TAS Traceable Author Statement more info	PubMed
immunoglobulin mediated immune response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
inflammatory response	TAS Traceable Author Statement more info	PubMed
NOT mast cell activation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
mature B cell differentiation involved in immune response	TAS Traceable Author Statement more info	PubMed
negative regulation of B cell activation	TAS Traceable Author Statement more info	PubMed
negative regulation of B cell proliferation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
negative regulation of B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of acute inflammatory response to antigenic stimulus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
negative regulation of antibody-dependent cellular cytotoxicity	TAS Traceable Author Statement more info	PubMed
negative regulation of cytokine secretion	TAS Traceable Author Statement more info	PubMed
negative regulation of cytotoxic T cell degranulation	TAS Traceable Author Statement more info	PubMed
negative regulation of dendritic cell antigen processing and presentation	TAS Traceable Author Statement more info	PubMed
negative regulation of dendritic cell differentiation	TAS Traceable Author Statement more info	PubMed
negative regulation of humoral immune response mediated by circulating immunoglobulin	ISS Inferred from Sequence or Structural Similarity more info	PubMed
negative regulation of immune response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
negative regulation of immunoglobulin production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
negative regulation of interleukin-10 production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
negative regulation of macrophage activation	TAS Traceable Author Statement more info	PubMed
negative regulation of neutrophil activation	TAS Traceable Author Statement more info	PubMed
negative regulation of phagocytosis	TAS Traceable Author Statement more info	PubMed
negative regulation of type I hypersensitivity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
phagocytosis, engulfment	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of humoral immune response	TAS Traceable Author Statement more info	PubMed
positive regulation of neuron death	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info	PubMed
receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
regulation of B cell antigen processing and presentation	TAS Traceable Author Statement more info	PubMed
regulation of adaptive immune response	TAS Traceable Author Statement more info	PubMed
regulation of dendritic spine maintenance	IGI Inferred from Genetic Interaction more info	PubMed
regulation of immune complex clearance by monocytes and macrophages	TAS Traceable Author Statement more info	PubMed
regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
regulation of immune response	TAS Traceable Author Statement more info
regulation of innate immune response	TAS Traceable Author Statement more info	PubMed
regulation of signaling receptor activity	TAS Traceable Author Statement more info	PubMed
response to bacterium	ISS Inferred from Sequence or Structural Similarity more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed
viral process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell body	ISS Inferred from Sequence or Structural Similarity more info	PubMed
dendritic spine	ISS Inferred from Sequence or Structural Similarity more info	PubMed
external side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
integral component of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
integral component of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: low affinity immunoglobulin gamma Fc region receptor II-b

Names: CDw32; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc gamma RIIb; Fc gamma receptor IIb; Fc-gamma RII-c; Fc-gamma-RIIc; IgG Fc receptor II-c; Low affinity immunoglobulin gamma Fc region receptor II-c; fc-gamma RII-b; fc-gamma-RIIb; fcRII-b; igG Fc receptor II-b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023318.1 RefSeqGene

Range

5001..20540

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001002273.2 → NP_001002273.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform 2 precursor

See identical proteins and their annotated locations for NP_001002273.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK308150, AW452813, DC381078, U87571

UniProtKB/Swiss-Prot

P31994

Conserved Domains (2) summary

cd05752
Location:49 → 127

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:131 → 213

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
NM_001002274.2 → NP_001002274.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform 3 precursor

See identical proteins and their annotated locations for NP_001002274.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK308150, AW452813, DC381078, U87564

Consensus CDS

CCDS30925.1

UniProtKB/Swiss-Prot

P31994

Related

ENSP00000236937.9, ENST00000236937.13

Conserved Domains (2) summary

cd05752
Location:50 → 128

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:132 → 214

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
NM_001002275.2 → NP_001002275.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform 4 precursor

See identical proteins and their annotated locations for NP_001002275.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.

Source sequence(s)

AK308150, AW452813, DC381078, U87570

UniProtKB/Swiss-Prot

P31994

Conserved Domains (2) summary

cd05752
Location:49 → 127

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:131 → 213

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
NM_001190828.1 → NP_001177757.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform 5

See identical proteins and their annotated locations for NP_001177757.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK308150, AW452813, DC381078, M31933, U87560

Consensus CDS

CCDS53414.1

UniProtKB/Swiss-Prot

P31994

Related

ENSP00000356938.4, ENST00000367961.8

Conserved Domains (3) summary

cd05752
Location:43 → 121

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:125 → 207

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:131 → 207

IG_like; Immunoglobulin like
NM_004001.4 → NP_003992.3 low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor

See identical proteins and their annotated locations for NP_003992.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK308150, AW452813, DC381078, U87560

Consensus CDS

CCDS30924.1

UniProtKB/Swiss-Prot

P31994

Related

ENSP00000351497.5, ENST00000358671.9

Conserved Domains (2) summary

cd05752
Location:50 → 128

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:132 → 214

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p13 Primary Assembly

Range

161647243..161678654

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024454044.1 → XP_024309812.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform X3

Conserved Domains (2) summary

cd05752
Location:49 → 127

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:131 → 213

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
XM_024454045.1 → XP_024309813.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform X4

Conserved Domains (2) summary

cd05752
Location:49 → 127

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:131 → 213

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
XM_017000670.2 → XP_016856159.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform X2
XM_024454043.1 → XP_024309811.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform X1

Conserved Domains (2) summary

cd05752
Location:50 → 128

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:132 → 214

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
XM_024454047.1 → XP_024309815.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform X5

Conserved Domains (2) summary

cd05752
Location:50 → 128

Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

cd05753
Location:132 → 214

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins