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FCGR2B Fc fragment of IgG receptor IIb [ Homo sapiens (human) ]

Gene ID: 2213, updated on 1-Jun-2020

Summary

Official Symbol
FCGR2Bprovided by HGNC
Official Full Name
Fc fragment of IgG receptor IIbprovided by HGNC
Primary source
HGNC:HGNC:3618
See related
Ensembl:ENSG00000072694 MIM:604590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD32; FCG2; CD32B; FCGR2; IGFR2; FCGR2C; FcRII-c
Summary
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Expression
Biased expression in placenta (RPKM 92.9), appendix (RPKM 9.6) and 6 other tissues See more
Orthologs

Genomic context

See FCGR2B in Genome Data Viewer
Location:
1q23.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161647243..161678654)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161632905..161648444)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S23 pseudogene 9 Neighboring gene Fc fragment of IgG receptor IIIb Neighboring gene ribosomal protein L31 pseudogene 11 Neighboring gene Fc receptor like A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Susceptibility to malaria
MedGen: C1970028 OMIM: 611162 GeneReviews: Not available
Compare labs
Systemic lupus erythematosus
MedGen: C0024141 OMIM: 152700 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
Nef nef HIV-1 Nef downregulates Fc-gamma Receptor II in human monocytes/macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
IgG binding IDA
Inferred from Direct Assay
more info
PubMed 
amyloid-beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
amyloid-beta binding TAS
Traceable Author Statement
more info
PubMed 
low-affinity IgG receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to amyloid-beta ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cellular response to molecule of bacterial origin ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cerebellum development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
defense response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
follicular B cell differentiation TAS
Traceable Author Statement
more info
PubMed 
follicular dendritic cell activation TAS
Traceable Author Statement
more info
PubMed 
immune complex clearance by monocytes and macrophages TAS
Traceable Author Statement
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
immunoglobulin mediated immune response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
NOT mast cell activation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mature B cell differentiation involved in immune response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of B cell activation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of acute inflammatory response to antigenic stimulus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of antibody-dependent cellular cytotoxicity TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cytokine secretion TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cytotoxic T cell degranulation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of dendritic cell antigen processing and presentation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of dendritic cell differentiation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of humoral immune response mediated by circulating immunoglobulin ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of immune response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of immunoglobulin production ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of interleukin-10 production ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of macrophage activation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of neutrophil activation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of phagocytosis TAS
Traceable Author Statement
more info
PubMed 
negative regulation of type I hypersensitivity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
phagocytosis, engulfment ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of humoral immune response TAS
Traceable Author Statement
more info
PubMed 
positive regulation of neuron death ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of B cell antigen processing and presentation TAS
Traceable Author Statement
more info
PubMed 
regulation of adaptive immune response TAS
Traceable Author Statement
more info
PubMed 
regulation of dendritic spine maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of immune complex clearance by monocytes and macrophages TAS
Traceable Author Statement
more info
PubMed 
regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
regulation of innate immune response TAS
Traceable Author Statement
more info
PubMed 
regulation of signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell body ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
external side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
low affinity immunoglobulin gamma Fc region receptor II-b
Names
CDw32
Fc fragment of IgG, low affinity II, receptor for (CD32)
Fc fragment of IgG, low affinity IIb, receptor (CD32)
Fc fragment of IgG, low affinity IIb, receptor for (CD32)
Fc gamma RIIb
Fc gamma receptor IIb
Fc-gamma RII-c
Fc-gamma-RIIc
IgG Fc receptor II-c
Low affinity immunoglobulin gamma Fc region receptor II-c
fc-gamma RII-b
fc-gamma-RIIb
fcRII-b
igG Fc receptor II-b

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023318.1 RefSeqGene

    Range
    5001..20540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001002273.2NP_001002273.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 2 precursor

    See identical proteins and their annotated locations for NP_001002273.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK308150, AW452813, DC381078, U87571
    UniProtKB/Swiss-Prot
    P31994
    Conserved Domains (2) summary
    cd05752
    Location:49127
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:131213
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
  2. NM_001002274.2NP_001002274.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 3 precursor

    See identical proteins and their annotated locations for NP_001002274.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK308150, AW452813, DC381078, U87564
    Consensus CDS
    CCDS30925.1
    UniProtKB/Swiss-Prot
    P31994
    Related
    ENSP00000236937.9, ENST00000236937.13
    Conserved Domains (2) summary
    cd05752
    Location:50128
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:132214
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
  3. NM_001002275.2NP_001002275.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 4 precursor

    See identical proteins and their annotated locations for NP_001002275.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AK308150, AW452813, DC381078, U87570
    UniProtKB/Swiss-Prot
    P31994
    Conserved Domains (2) summary
    cd05752
    Location:49127
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:131213
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
  4. NM_001190828.1NP_001177757.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform 5

    See identical proteins and their annotated locations for NP_001177757.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK308150, AW452813, DC381078, M31933, U87560
    Consensus CDS
    CCDS53414.1
    UniProtKB/Swiss-Prot
    P31994
    Related
    ENSP00000356938.4, ENST00000367961.8
    Conserved Domains (3) summary
    cd05752
    Location:43121
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:125207
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:131207
    IG_like; Immunoglobulin like
  5. NM_004001.4NP_003992.3  low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor

    See identical proteins and their annotated locations for NP_003992.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK308150, AW452813, DC381078, U87560
    Consensus CDS
    CCDS30924.1
    UniProtKB/Swiss-Prot
    P31994
    Related
    ENSP00000351497.5, ENST00000358671.9
    Conserved Domains (2) summary
    cd05752
    Location:50128
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:132214
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    161647243..161678654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454044.1XP_024309812.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform X3

    Conserved Domains (2) summary
    cd05752
    Location:49127
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:131213
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
  2. XM_024454045.1XP_024309813.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform X4

    Conserved Domains (2) summary
    cd05752
    Location:49127
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:131213
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
  3. XM_017000670.2XP_016856159.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform X2

  4. XM_024454043.1XP_024309811.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform X1

    Conserved Domains (2) summary
    cd05752
    Location:50128
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:132214
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
  5. XM_024454047.1XP_024309815.1  low affinity immunoglobulin gamma Fc region receptor II-b isoform X5

    Conserved Domains (2) summary
    cd05752
    Location:50128
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:132214
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

RNA

  1. XR_002959731.1 RNA Sequence

    Related
    ENST00000674150.1
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