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Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 [ Mus musculus (house mouse) ]

Gene ID: 22123, updated on 2-Nov-2024

Summary

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Official Symbol
Psmd3provided by MGI
Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3provided by MGI
Primary source
MGI:MGI:98858
See related
Ensembl:ENSMUSG00000017221 AllianceGenome:MGI:98858
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Psd3; AntP91a; Tstap91a; D11Bwg1349e
Summary
Predicted to enable enzyme regulator activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Orthologous to human PSMD3 (proteasome 26S subunit, non-ATPase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 118.0), ovary adult (RPKM 104.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Psmd3 in Genome Data Viewer
Location:
11 D; 11 62.39 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98573380..98586804)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98682554..98695978)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene gasdermin A2 Neighboring gene STARR-positive B cell enhancer ABC_E7059 Neighboring gene gasdermin A Neighboring gene STARR-seq mESC enhancer starr_30673 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98543708-98543891 Neighboring gene predicted gene, 38985 Neighboring gene colony stimulating factor 3 (granulocyte) Neighboring gene mediator complex subunit 24 Neighboring gene predicted gene, 22059

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Immunogenic (tum-) variants of mouse tumor P815: cloning of the gene of tum- antigen P91A and identification of the tum- mutation. De Plaen E, et al. Proc Natl Acad Sci U S A, 1988 Apr. PMID 3127830, Free PMC Article
  2. Structure of the gene of tum- transplantation antigen P35B: presence of a point mutation in the antigenic allele. Szikora JP, et al. EMBO J, 1990 Apr. PMID 2108859, Free PMC Article
  3. Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. I. Rejection by syngeneic mice. Uyttenhove C, et al. J Exp Med, 1980 Nov 1. PMID 6776226, Free PMC Article
  4. Structure of the gene of tum- transplantation antigen P91A: the mutated exon encodes a peptide recognized with Ld by cytolytic T cells. Lurquin C, et al. Cell, 1989 Jul 28. PMID 2568889
  5. Puromycin-sensitive aminopeptidase gene (Psa) maps to mouse chromosome 11. Osada T, et al. Genomics, 1999 Mar 15. PMID 10087210

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of proteasome accessory complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
26S proteasome non-ATPase regulatory subunit 3
Names
26S proteasome regulatory subunit RPN3
26S proteasome regulatory subunit S3
proteasome subunit p58
tissue specific transplantation antigen P91A
transplantation antigen P91A
tum-P91A antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009439.1 → NP_033465.1  26S proteasome non-ATPase regulatory subunit 3

    See identical proteins and their annotated locations for NP_033465.1

    Status: VALIDATED

    Source sequence(s)
    BC003197
    Consensus CDS
    CCDS25359.1
    UniProtKB/Swiss-Prot
    P14685, Q3TP95, Q99LL7
    UniProtKB/TrEMBL
    Q8BK46
    Related
    ENSMUSP00000017365.9, ENSMUST00000017365.15
    Conserved Domains (2) summary
    pfam01399
    Location:354 → 458
    PCI; PCI domain
    pfam08375
    Location:461 → 519
    Rpn3_C; Proteasome regulatory subunit C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98573380..98586804
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14685.3 GenPept UniProtKB/Swiss-Prot:P14685

Gene LinkOut

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