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PRSS54 serine protease 54 [ Homo sapiens (human) ]

Gene ID: 221191, updated on 11-Jun-2021

Summary

Official Symbol
PRSS54provided by HGNC
Official Full Name
serine protease 54provided by HGNC
Primary source
HGNC:HGNC:26336
See related
Ensembl:ENSG00000103023
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT67; KLKBL4
Summary
This gene encodes a putative serine-type endopeptidase containing the peptidase S1 domain. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Expression
Biased expression in testis (RPKM 23.6), brain (RPKM 3.1) and 1 other tissue See more
Orthologs
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Genomic context

See PRSS54 in Genome Data Viewer
Location:
16q21
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (58279997..58295025, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (58313901..58328929, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 113 Neighboring gene uncharacterized LOC105371293 Neighboring gene Sharpr-MPRA regulatory region 4701 Neighboring gene RNA, U6 small nuclear 1110, pseudogene Neighboring gene RNA, U6 small nuclear 269, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • FLJ25339

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
inactive serine protease 54
Names
cancer/testis antigen 67
plasma kallikrein-like protein 4
protease, serine 54
testis tissue sperm-binding protein Li 40a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080492.2NP_001073961.1  inactive serine protease 54 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001073961.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC009107
    Consensus CDS
    CCDS32463.1
    UniProtKB/Swiss-Prot
    Q6PEW0
    UniProtKB/TrEMBL
    A0A140VKC3
    Related
    ENSP00000219301.4, ENST00000219301.8
    Conserved Domains (2) summary
    smart00020
    Location:52264
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:52264
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_001305173.2NP_001292102.1  inactive serine protease 54 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001292102.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC009107
    Consensus CDS
    CCDS32463.1
    UniProtKB/Swiss-Prot
    Q6PEW0
    UniProtKB/TrEMBL
    A0A140VKC3
    Related
    ENSP00000455024.1, ENST00000567164.6
    Conserved Domains (2) summary
    smart00020
    Location:52264
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:52264
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. NM_001305174.2NP_001292103.1  inactive serine protease 54 isoform 2

    See identical proteins and their annotated locations for NP_001292103.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC009107
    Consensus CDS
    CCDS76882.1
    UniProtKB/TrEMBL
    F5H6C6
    Related
    ENSP00000437705.1, ENST00000543437.5
    Conserved Domains (1) summary
    cl21584
    Location:9165
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    58279997..58295025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450191.1XP_024305959.1  inactive serine protease 54 isoform X1

    Conserved Domains (1) summary
    cl21584
    Location:9165
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
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