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ARL5B ADP ribosylation factor like GTPase 5B [ Homo sapiens (human) ]

Gene ID: 221079, updated on 13-Mar-2020

Summary

Official Symbol
ARL5Bprovided by HGNC
Official Full Name
ADP ribosylation factor like GTPase 5Bprovided by HGNC
Primary source
HGNC:HGNC:23052
See related
Ensembl:ENSG00000165997 MIM:608909
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARL8
Summary
ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010]
Expression
Ubiquitous expression in adrenal (RPKM 13.8), gall bladder (RPKM 10.5) and 25 other tissues See more
Orthologs

Genomic context

See ARL5B in Genome Data Viewer
Location:
10p12.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (18659335..18681639)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (18948264..18970568)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit beta 2 Neighboring gene uncharacterized LOC107984213 Neighboring gene NOP2/Sun RNA methyltransferase 6 Neighboring gene uncharacterized LOC105376440 Neighboring gene AIFM1 pseudogene 1 Neighboring gene uncharacterized LOC107984180

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Genome-wide shRNA screening identifies ARL5B, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to Golgi membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylation factor-like protein 5B
Names
ADP-ribosylation factor-like 5B
ADP-ribosylation factor-like 8
ADP-ribosylation factor-like protein 8
ADP-ribosylation-like factor 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178815.5NP_848930.1  ADP-ribosylation factor-like protein 5B

    See identical proteins and their annotated locations for NP_848930.1

    Status: VALIDATED

    Source sequence(s)
    AL133611, AL512641
    Consensus CDS
    CCDS7131.1
    UniProtKB/Swiss-Prot
    Q96KC2
    UniProtKB/TrEMBL
    B0YIW9
    Related
    ENSP00000366487.3, ENST00000377275.4
    Conserved Domains (1) summary
    cd04153
    Location:3175
    Arl5_Arl8; Arf-like 5 (Arl5) and 8 (Arl8) GTPases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    18659335..18681639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252400.1XP_005252457.1  ADP-ribosylation factor-like protein 5B isoform X1

    See identical proteins and their annotated locations for XP_005252457.1

    Conserved Domains (2) summary
    smart00178
    Location:8148
    SAR; Sar1p-like members of the Ras-family of small GTPases
    cl21455
    Location:3147
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_005252401.4XP_005252458.1  ADP-ribosylation factor-like protein 5B isoform X2

    See identical proteins and their annotated locations for XP_005252458.1

    Conserved Domains (1) summary
    cl21455
    Location:1138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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