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Trp53 transformation related protein 53 [ Mus musculus (house mouse) ]

Gene ID: 22059, updated on 30-Nov-2021

Summary

Official Symbol
Trp53provided by MGI
Official Full Name
transformation related protein 53provided by MGI
Primary source
MGI:MGI:98834
See related
Ensembl:ENSMUSG00000059552
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
bbl; bfy; bhy; p44; p53; Tp53
Summary
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thymus adult (RPKM 69.1), ovary adult (RPKM 56.5) and 28 other tissues See more
Orthologs
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Genomic context

See Trp53 in Genome Data Viewer
Location:
11 B3; 11 42.83 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69471174..69482699)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69580348..69591873)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69393861..69405375)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ephrin B3 Neighboring gene WD repeat containing, antisense to Trp53 Neighboring gene ribosomal protein S27, pseudogene 2 Neighboring gene ATPase, Na+/K+ transporting, beta 2 polypeptide Neighboring gene sex hormone binding globulin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP-dependent DNA/DNA annealing activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IGI
Inferred from Genetic Interaction
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables MDM2/MDM4 family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables MDM2/MDM4 family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables TFIID-class transcription factor complex binding ISO
Inferred from Sequence Orthology
more info
 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
 
enables core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables general transcription initiation factor binding ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein self-association ISO
Inferred from Sequence Orthology
more info
 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ER overload response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T cell differentiation in thymus IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell proliferation involved in immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in bone marrow development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell aging IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell aging ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular protein localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to UV IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to UV-C IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to actinomycin D ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to gamma radiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to ionizing radiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to ionizing radiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to stress IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within central nervous system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cerebellum development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chromatin assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromosome organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in circadian behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic organ development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gastrulation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in hematopoietic stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in interferon-gamma-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitochondrial DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitotic G1 DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic G1 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within necroptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of G1 to G0 transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of glucose catabolic process to lactate via pyruvate IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of mitophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of production of miRNAs involved in gene silencing by miRNA IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 
involved_in oligodendrocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in oxidative stress-induced premature senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mitochondrial membrane permeability IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of production of miRNAs involved in gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of programmed necrotic cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of thymocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of thymocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription from RNA polymerase II promoter in response to stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription from RNA polymerase II promoter in response to stress ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter in response to stress ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within programmed cell death IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein stabilization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rRNA transcription IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of DNA damage response, signal transduction by p53 class mediator IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_negative_effect regulation of cell cycle G2/M phase transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cellular senescence IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of fibroblast apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of hydrogen peroxide-induced cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of intracellular pH ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mitochondrial membrane permeability involved in apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of thymocyte apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of tissue remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription from RNA polymerase II promoter in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription from RNA polymerase II promoter in response to DNA damage ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within release of cytochrome c from mitochondria IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in replicative senescence ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to UV IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to X-ray IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to X-ray IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to X-ray ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to gamma radiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to salt stress IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within somitogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in viral process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
colocalizes_with nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in replication fork IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cellular tumor antigen p53
Names
ME-delta123p53
mutant p53
p53 cellular tumor antigen
tumor suppressor p53
tumor supressor p53

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127233.1NP_001120705.1  cellular tumor antigen p53 isoform b

    See identical proteins and their annotated locations for NP_001120705.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate splice site for the 3' exon, as compared to variant 1. The resulting isoform (b), also known p53AS, has a shorter and different C-terminus, as compared to isoform a.
    Source sequence(s)
    AI323249, AV450598, M13874, X01237
    Consensus CDS
    CCDS48826.1
    UniProtKB/Swiss-Prot
    P02340
    UniProtKB/TrEMBL
    Q80ZA1
    Related
    ENSMUSP00000127130.2, ENSMUST00000171247.8
    Conserved Domains (3) summary
    cd08367
    Location:106286
    P53; P53 DNA-binding domain
    pfam07710
    Location:316352
    P53_tetramer; P53 tetramerisation motif
    pfam08563
    Location:931
    P53_TAD; P53 transactivation motif
  2. NM_011640.3NP_035770.2  cellular tumor antigen p53 isoform a

    See identical proteins and their annotated locations for NP_035770.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AB221571, AI323249, AK147815, AV450598, X01237
    Consensus CDS
    CCDS36193.1
    UniProtKB/Swiss-Prot
    P02340
    UniProtKB/TrEMBL
    Q3UGQ1, Q549C9
    Related
    ENSMUSP00000104298.4, ENSMUST00000108658.10
    Conserved Domains (3) summary
    cd08367
    Location:106286
    P53; P53 DNA-binding domain
    pfam07710
    Location:316352
    P53_tetramer; P53 tetramerisation motif
    pfam08563
    Location:931
    P53_TAD; P53 transactivation motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69471174..69482699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245922.1XP_030101782.1  cellular tumor antigen p53 isoform X1

    Conserved Domains (3) summary
    cd08367
    Location:106286
    P53; P53 DNA-binding domain
    pfam07710
    Location:316352
    P53_tetramer; P53 tetramerisation motif
    pfam08563
    Location:931
    P53_TAD; P53 transactivation motif
  2. XM_030245923.2XP_030101783.1  cellular tumor antigen p53 isoform X2

    Conserved Domains (3) summary
    cd08367
    Location:106286
    P53; P53 DNA-binding domain
    pfam07710
    Location:316352
    P53_tetramer; P53 tetramerisation motif
    pfam08563
    Location:931
    P53_TAD; P53 transactivation motif
  3. XM_006533157.5XP_006533220.1  cellular tumor antigen p53 isoform X1

    See identical proteins and their annotated locations for XP_006533220.1

    UniProtKB/Swiss-Prot
    P02340
    UniProtKB/TrEMBL
    Q549C9
    Conserved Domains (3) summary
    cd08367
    Location:106286
    P53; P53 DNA-binding domain
    pfam07710
    Location:316352
    P53_tetramer; P53 tetramerisation motif
    pfam08563
    Location:931
    P53_TAD; P53 transactivation motif
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