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TP53 tumor protein p53 [ Homo sapiens (human) ]

Gene ID: 7157, updated on 5-Jul-2020

Summary

Official Symbol
TP53provided by HGNC
Official Full Name
tumor protein p53provided by HGNC
Primary source
HGNC:HGNC:11998
See related
Ensembl:ENSG00000141510 MIM:191170
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P53; BCC7; LFS1; BMFS5; TRP53
Summary
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Expression
Ubiquitous expression in spleen (RPKM 13.2), lymph node (RPKM 13.1) and 25 other tissues See more
Orthologs

Genomic context

See TP53 in Genome Data Viewer
Location:
17p13.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (7668402..7687550, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7571720..7590868, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene sex hormone binding globulin Neighboring gene spermidine/spermine N1-acetyltransferase family member 2 Neighboring gene ATPase Na+/K+ transporting subunit beta 2 Neighboring gene WD repeat containing antisense to TP53 Neighboring gene ephrin B3 Neighboring gene dynein axonemal heavy chain 2 Neighboring gene ribosomal protein L29 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Professional guidelines

Description
Professional guideline
ACMG 2013

The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in TP53 that are pathogenic or expected to be pathogenic.

GuidelinePubMed

Associated conditions

Description Tests
Adrenocortical carcinoma, hereditary
MedGen: C1859972 OMIM: 202300 GeneReviews: Not available
Compare labs
Basal cell carcinoma, susceptibility to, 7
MedGen: C3553606 OMIM: 614740 GeneReviews: Not available
Compare labs
BONE MARROW FAILURE SYNDROME 5
MedGen: C4748488 OMIM: 618165 GeneReviews: Not available
Compare labs
Carcinoma of pancreas
MedGen: C0235974 OMIM: 260350 GeneReviews: Not available
Compare labs
Choroid plexus papilloma
MedGen: C0205770 OMIM: 260500 GeneReviews: Not available
Compare labs
Colorectal cancer
MedGen: C1527249 OMIM: 114500 GeneReviews: Lynch Syndrome
Compare labs
Familial cancer of breast Compare labs
Glioma susceptibility 1
MedGen: C2750850 OMIM: 137800 GeneReviews: Not available
Compare labs
Hepatocellular carcinoma
MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
Compare labs
Li-Fraumeni syndrome 1 Compare labs
Nasopharyngeal carcinoma
MedGen: C2931822 OMIM: 607107 GeneReviews: Not available
Compare labs
Osteosarcoma
MedGen: C0029463 OMIM: 259500 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2016-09-08)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2016-09-08)

ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
NHGRI GWA Catalog
A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.
NHGRI GWA Catalog
Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
NHGRI GWA Catalog
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Latent HIV infection increases TP53 (p53) expression and phosphorylation PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 Env gp120 induces TP53 (p53) via binding to the CXCR4 co-receptor PubMed
env HIV-1 Env gp120 treatment activates TP53 (p53) which contributes to the upregulation of the mitochondrial redox enzyme PRODH (POX) PubMed
env HIV-1 gp120 is potentially cytotoxic to human cells through the induction of p53, which may eventually lead to induction of apoptosis PubMed
env Caspase 8 proteolytic target protein Bid is cleaved and undergoes mitochondrial translocation in gp120-treated p53 expression neurons PubMed
env HIV-1 gp120-mediated activation of caspase 8 occurs in a p53 independent manner, while HIV-1 gp120-mediated activation of caspase 3 requires p53 PubMed
env Tumor suppressor protein PML is required for the activating phosphorylation of ATM, p38 MAPK, and p53 in HIV-1 Env-elicited syncytia PubMed
env p38 MAPK-mediated p53 phosphorylation on serine 46 contributes to apoptosis induced by the HIV-1 envelope glycoprotein complex (gp120/gp41) PubMed
env Syncytial apoptosis mediated by the fusion of cells expressing HIV-1 gp120 with cells expressing the CD4/CXCR4 receptor/coreceptor complex causes phosphorylation of p53 on serine 15 and Bax upregulation PubMed
Nef nef Assays with phage-displayed Nef from HIV-1 NL4-3 have been used to identify a series of guanidine alkaloid-based inhibitors of Nef interactions with p53, actin, and p56(lck) PubMed
nef HIV-1 Nef binds directly to tumor suppressor protein p53; an N-terminal 57-residue fragment of Nef (Nef 1-57) contains the p53-binding domain PubMed
Pr55(Gag) gag HIV-1 infection upregulates the expression of p53 in CD4+ T cells and PBMCs in terms of increased cellular HIV-1 Gag/p24 levels PubMed
Rev rev HIV-1 Tat reactivates latent HIV-1 proviruses in J1.1 and ACH-2 cell lines and promotes p53-induced apoptosis in the presence of Rev PubMed
Tat tat Expression of p53 inhibits HIV-1 Tat activity in a dose-dependent manner and PKR plays a crucial role in p53-mediated Tat suppression in p53-/- cells PubMed
tat Wild-type p53 is a potent inhibitor of HIV-1 Tat transactivation of the HIV-1 LTR promoter in Jurkat T cells and Hep3B cells PubMed
tat HIV-1 Tat downregulates the expression of p53, suggesting a mechanism for HIV-1-mediated transformation of infected cells PubMed
tat Treatment with HIV-Tat and morphine activates extracellular signal-regulated kinase-1/2 (ERK1/2), upregulates p53 and p21 levels, and downregulates cyclin D1 and Akt levels in human fetal brain-derived neural precursor cells PubMed
tat HIV-1 Tat activates the p53 transcription factor pathway leading to the induction of endogenous p53 and p73 in neuronal cells PubMed
tat HIV-1 Tat inhibits SIRT1 and increases acetylation of p53, which leads to activation of p21 and BAX in HeLa-CD4+ cells PubMed
tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed
tat HIV-1 Tat reactivates latent HIV-1 proviruses in J1.1 and ACH-2 cell lines and promotes p53-induced apoptosis in the presence of Rev PubMed
tat The p53 tetramerization domain (residues 326-355) binds directly to residues 1-35 and 47-57 in HIV-1 Tat as evidenced by using peptide mapping, fluorescence anisotropy, and NMR spectroscopy PubMed
tat In the absence of either p53 or p73, Tat fails to induce dendritic retraction or to activate the proapoptotic proteins, such as Bax PubMed
tat Activation of p38 MAPK in HIV-infected cells mediated by Tat leads to the phosphorylation of p53 which subsequently upregulates CAV-1 expression PubMed
tat HIV-1 Tat binds to p53, an interaction mediated by the basic region of Tat (amino acids 49-57) and the acidic O2 domain of p53 (amino acids 341-354 PubMed
tat Supernatants from HIV-1 Tat-transfected monocytoid cells induces p53 expression in neurons, indicating a role for Tat in the neuropathogenesis of HIV-1 PubMed
tat HIV-1 Tat inhibits p53-responsive transcription by binding to histone acetyltransferases and repressing the acetylation of p53 on residue Lys-320, alluding to a mechanism whereby Tat may impair p53 functions, thus favoring the establishment of neoplasia PubMed
tat HIV-1 Tat and p53 cooperate in the activation of HIV-1 gene expression in SaOS2 cells PubMed
Vif vif HIV-1 Vif stabilizes TP53 by blocking MDM2-induced ubiquitination and inhibits MDM2-mediated nuclear export of TP53, leading to support viral replication through inducing G2 cell cycle arrest PubMed
vif The N-terminal region (residues 1-50) of HIV-1 Vif is important for binding to TP53 PubMed
Vpr vpr HIV-1 Vpr interacts with p53 in a complex with the transcription factor Sp1 that modulates viral gene transcription from the HIV-1 LTR promoter PubMed
vpr HIV-1 Vpr downregulates proliferation-associated protein 2G4 (PA2G4) and upregulates p53 in glioblastoma U87MG cells PubMed
vpr Exposure of cultured human primary astrocytes to HIV-1 Vpr induces p53 up-regulation, loss of mitochondrial membrane potential, and caspase-6 activation followed by cell injury PubMed
vpr Soluble HIV-1 Vpr causes neuronal apoptosis, involving cytochrome c extravasation, p53 induction, and activation of caspase-9 PubMed
vpr HIV-1 Vpr inhibits the interaction of p53 and Rad51 in chromatin fractions, as observed under irradiation-induced DNA double-strand breaks PubMed
vpr Results from GST pull-down assays show the association of Vpr with p53 in extracts containing Sp1, suggesting the physical interaction of Vpr with Sp1 and p53 could modulate transcriptional activity of p21 PubMed
vpr Activation of p21/Waf1/Cip1 by HIV-1 Vpr appears to be regulated by p53 PubMed
vpr HIV-1 Vpr can neutralize inhibitory effects of the human homologue of yeast Rad23 protein A (hHR23A) on p53, thereby activating p53 transcriptional activity PubMed
vpr Overexpression of p53 decreases the level of activation of the viral LTR promoter by HIV-1 Vpr PubMed
Vpu vpu HIV-1 Vpu expression results in significant upregulation of phosphorylated p53. Vpu contributes to p53-dependent apoptosis in HIV-1-infected cells PubMed
vpu HIV-1 Vpu expression leads to stabilization and upregulation of p53 via inhibiting association of p53 with beta-TrCP and its subsequent ubiquitination PubMed
integrase gag-pol HIV-1 IN-mediated proviral DNA integration triggers cell death during HIV-1 infection. The mechanism of killing during viral integration involves activation of DNA-PK, which causes phosphorylation of p53 and histone gammaH2AX PubMed
reverse transcriptase gag-pol Tumor suppressor protein p53 displays 3' --> 5' exonuclease activity, and interaction of p53 with HIV-1 reverse transcriptase (RT) can provide a proofreading function for HIV-1 RT PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ92943

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
MDM2/MDM4 family protein binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
TFIID-class transcription factor complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
copper ion binding IDA
Inferred from Direct Assay
more info
PubMed 
core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
disordered domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase regulator activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 2A binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein self-association IPI
Inferred from Physical Interaction
more info
PubMed 
receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
B cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 
DNA damage response, signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA strand renaturation IDA
Inferred from Direct Assay
more info
PubMed 
ER overload response IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II preinitiation complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
Ras protein signal transduction IEP
Inferred from Expression Pattern
more info
PubMed 
T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
T cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 
T cell proliferation involved in immune response IEA
Inferred from Electronic Annotation
more info
 
autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone marrow development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to UV-C IEA
Inferred from Electronic Annotation
more info
 
cellular response to actinomycin D IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to gamma radiation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to glucose starvation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebellum development IEA
Inferred from Electronic Annotation
more info
 
chromatin assembly IDA
Inferred from Direct Assay
more info
PubMed 
circadian behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
determination of adult lifespan ISS
Inferred from Sequence or Structural Similarity
more info
 
double-strand break repair IEA
Inferred from Electronic Annotation
more info
 
embryonic organ development IEA
Inferred from Electronic Annotation
more info
 
entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
 
gastrulation IEA
Inferred from Electronic Annotation
more info
 
hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
interferon-gamma-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
intrinsic apoptotic signaling pathway by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
mRNA transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial DNA repair IEA
Inferred from Electronic Annotation
more info
 
mitotic G1 DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
necroptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of glucose catabolic process to lactate via pyruvate IEA
Inferred from Electronic Annotation
more info
 
negative regulation of helicase activity TAS
Traceable Author Statement
more info
PubMed 
negative regulation of mitophagy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of pentose-phosphate shunt IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of production of miRNAs involved in gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
negative regulation of proteolysis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of telomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
oligodendrocyte apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidative stress-induced premature senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell aging IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell cycle arrest IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of execution phase of apoptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mitochondrial membrane permeability IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of pri-miRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pri-miRNA transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of production of miRNAs involved in gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein export from nucleus TAS
Traceable Author Statement
more info
 
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of thymocyte apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter in response to stress IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
protein localization IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IEA
Inferred from Electronic Annotation
more info
 
protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
rRNA transcription IEA
Inferred from Electronic Annotation
more info
 
regulation of DNA damage response, signal transduction by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process TAS
Traceable Author Statement
more info
 
regulation of cell cycle G2/M phase transition TAS
Traceable Author Statement
more info
 
regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
 
regulation of fibroblast apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of intrinsic apoptotic signaling pathway by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
regulation of mitochondrial membrane permeability involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
regulation of tissue remodeling IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
replicative senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to X-ray IEA
Inferred from Electronic Annotation
more info
 
response to antibiotic IEP
Inferred from Expression Pattern
more info
PubMed 
response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ischemia IEA
Inferred from Electronic Annotation
more info
 
response to salt stress IEA
Inferred from Electronic Annotation
more info
 
signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
somitogenesis IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
viral process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
replication fork IEA
Inferred from Electronic Annotation
more info
 
site of double-strand break IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IGI
Inferred from Genetic Interaction
more info
PubMed 

General protein information

Preferred Names
cellular tumor antigen p53
Names
antigen NY-CO-13
mutant tumor protein 53
p53 tumor suppressor
phosphoprotein p53
transformation-related protein 53
tumor protein 53
tumor supressor p53

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017013.2 RefSeqGene

    Range
    5001..24149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_321

mRNA and Protein(s)

  1. NM_000546.6NP_000537.3  cellular tumor antigen p53 isoform a

    See identical proteins and their annotated locations for NP_000537.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (a, also known as p53alpha) results from translation initiation at the upstream start codon. Both variants 1 and 2 encode isoform a, which is the longest isoform.
    Source sequence(s)
    AK223026, DA453049, X02469
    Consensus CDS
    CCDS11118.1
    UniProtKB/Swiss-Prot
    P04637
    UniProtKB/TrEMBL
    K7PPA8, Q53GA5
    Related
    ENSP00000269305.4, ENST00000269305.8
    Conserved Domains (3) summary
    pfam00870
    Location:95289
    P53; P53 DNA-binding domain
    pfam07710
    Location:319358
    P53_tetramer; P53 tetramerisation motif
    pfam08563
    Location:528
    P53_TAD; P53 transactivation motif
  2. NM_001126112.2NP_001119584.1  cellular tumor antigen p53 isoform a

    See identical proteins and their annotated locations for NP_001119584.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (a, also known as p53alpha) results from translation initiation at the upstream start codon. Both variants 1 and 2 encode isoform a, which is the longest isoform.
    Source sequence(s)
    AB082923, AK223026, DA453049, DQ186650, X02469
    Consensus CDS
    CCDS11118.1
    UniProtKB/Swiss-Prot
    P04637
    UniProtKB/TrEMBL
    K7PPA8, Q53GA5
    Related
    ENSP00000391478.2, ENST00000445888.6
    Conserved Domains (3) summary
    pfam00870
    Location:95289
    P53; P53 DNA-binding domain
    pfam07710
    Location:319358
    P53_tetramer; P53 tetramerisation motif
    pfam08563
    Location:528
    P53_TAD; P53 transactivation motif
  3. NM_001126113.2NP_001119585.1  cellular tumor antigen p53 isoform c

    See identical proteins and their annotated locations for NP_001119585.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an additional exon in the 3' coding region, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (c, also known as p53gamma) results from translation initiation at the upstream start codon. It has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK223026, DA453049, DQ186649, DQ186650
    Consensus CDS
    CCDS45605.1
    UniProtKB/Swiss-Prot
    P04637
    UniProtKB/TrEMBL
    Q53GA5
    Related
    ENSP00000398846.2, ENST00000455263.6
    Conserved Domains (2) summary
    pfam00870
    Location:95289
    P53; P53 DNA-binding domain
    pfam08563
    Location:528
    P53_TAD; P53 transactivation motif
  4. NM_001126114.2NP_001119586.1  cellular tumor antigen p53 isoform b

    See identical proteins and their annotated locations for NP_001119586.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an additional exon in the 3' coding region, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (b, also known as p53beta) results from translation initiation at the upstream start codon. It has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK223026, DA453049, DQ186648, DQ186649, DQ186650
    Consensus CDS
    CCDS45606.1
    UniProtKB/Swiss-Prot
    P04637
    UniProtKB/TrEMBL
    Q53GA5
    Related
    ENSP00000482258.1, ENST00000617185.4
    Conserved Domains (2) summary
    pfam00870
    Location:95289
    P53; P53 DNA-binding domain
    pfam08563
    Location:528
    P53_TAD; P53 transactivation motif
  5. NM_001126115.1NP_001119587.1  cellular tumor antigen p53 isoform d

    See identical proteins and their annotated locations for NP_001119587.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (d, also known as delta133p53alpha) results from translation initiation at the upstream start codon. It has a shorter N-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
    Source sequence(s)
    AC087388, AK223026, DQ186650
    Consensus CDS
    CCDS73966.1
    UniProtKB/Swiss-Prot
    P04637
    UniProtKB/TrEMBL
    Q53GA5
    Related
    ENSP00000481179.1, ENST00000504937.5
    Conserved Domains (2) summary
    pfam07710
    Location:187226
    P53_tetramer; P53 tetramerization motif
    cl14608
    Location:1157
    P53; P53 DNA-binding domain
  6. NM_001126116.1NP_001119588.1  cellular tumor antigen p53 isoform e

    See identical proteins and their annotated locations for NP_001119588.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (e, also known as delta133p53beta) results from translation initiation at the upstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
    Source sequence(s)
    AC087388, AK223026, DQ186651
    Consensus CDS
    CCDS73968.1
    UniProtKB/Swiss-Prot
    P04637
    UniProtKB/TrEMBL
    Q53GA5
    Related
    ENSP00000478499.1, ENST00000510385.5
    Conserved Domains (1) summary
    cl14608
    Location:1157
    P53; P53 DNA-binding domain
  7. NM_001126117.1NP_001119589.1  cellular tumor antigen p53 isoform f

    See identical proteins and their annotated locations for NP_001119589.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (f, also known as delta133p53gamma) results from translation initiation at the upstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
    Source sequence(s)
    AC087388, AK223026, DQ186652
    Consensus CDS
    CCDS73967.1
    UniProtKB/Swiss-Prot
    P04637
    UniProtKB/TrEMBL
    Q53GA5
    Related
    ENSP00000484409.1, ENST00000504290.5
    Conserved Domains (1) summary
    cl14608
    Location:1157
    P53; P53 DNA-binding domain
  8. NM_001126118.1NP_001119590.1  cellular tumor antigen p53 isoform g

    See identical proteins and their annotated locations for NP_001119590.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8, also known as p53I2) differs in the 5' UTR, and uses an in-frame downstream start codon, compared to variant 1. The encoded isoform (g, also known as delta40p53alpha or deltaNp53) has a shorter N-terminus, compared to isoform a. This variant is supported by data in PMID:21112961.
    Source sequence(s)
    AK223026, DA453049, DC347346, DQ186650, DQ191317, X60016
    Consensus CDS
    CCDS73969.1
    UniProtKB/Swiss-Prot
    P04637
    UniProtKB/TrEMBL
    H2EHT1, Q53GA5
    Related
    ENSP00000478219.1, ENST00000610292.4
    Conserved Domains (2) summary
    pfam00870
    Location:56250
    P53; P53 DNA-binding domain
    pfam07710
    Location:280319
    P53_tetramer; P53 tetramerisation motif
  9. NM_001276695.2NP_001263624.1  cellular tumor antigen p53 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an additional exon in the 3' coding region, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (h, also known as delta40p53gamma) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK223026, DA453049, DQ186649, DQ186650
    Consensus CDS
    CCDS73970.1
    UniProtKB/Swiss-Prot
    P04637
    UniProtKB/TrEMBL
    Q53GA5
    Related
    ENSP00000480868.1, ENST00000610538.4
    Conserved Domains (1) summary
    pfam00870
    Location:56250
    P53; P53 DNA-binding domain
  10. NM_001276696.2NP_001263625.1  cellular tumor antigen p53 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an additional exon in the 3' region, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (i, also known as delta40p53beta) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK223026, DA453049, DQ186648, DQ186649, DQ186650
    Consensus CDS
    CCDS73971.1
    UniProtKB/Swiss-Prot
    P04637
    UniProtKB/TrEMBL
    Q53GA5
    Related
    ENSP00000482222.1, ENST00000622645.4
    Conserved Domains (1) summary
    pfam00870
    Location:56250
    P53; P53 DNA-binding domain
  11. NM_001276697.2NP_001263626.1  cellular tumor antigen p53 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (j, also known as delta160p53alpha) results from translation initiation at the downstream start codon. It has a shorter N-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
    Source sequence(s)
    AK223026, DQ186650
    Consensus CDS
    CCDS73963.1
    UniProtKB/Swiss-Prot
    P04637
    UniProtKB/TrEMBL
    A0A087X1Q1, Q53GA5
    Conserved Domains (2) summary
    pfam07710
    Location:160199
    P53_tetramer; P53 tetramerisation motif
    cl14608
    Location:1130
    P53; P53 DNA-binding domain
  12. NM_001276698.2NP_001263627.1  cellular tumor antigen p53 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (k, also known as delta160p53beta) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
    Source sequence(s)
    AK223026, DQ186651
    Consensus CDS
    CCDS73965.1
    UniProtKB/Swiss-Prot
    P04637
    UniProtKB/TrEMBL
    A0A087WXZ1, Q53GA5
    Related
    ENSP00000481401.1, ENST00000618944.4
    Conserved Domains (1) summary
    cl14608
    Location:1130
    P53; P53 DNA-binding domain
  13. NM_001276699.2NP_001263628.1  cellular tumor antigen p53 isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate promoter and lacks multiple 5' exons, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (l, also known as delta160p53gamma) results from translation initiation at the downstream start codon. It has a shorter N-terminus and a distinct C-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
    Source sequence(s)
    AK223026, DQ186652
    Consensus CDS
    CCDS73964.1
    UniProtKB/Swiss-Prot
    P04637
    UniProtKB/TrEMBL
    A0A087WT22, Q53GA5
    Related
    ENSP00000477531.1, ENST00000610623.4
    Conserved Domains (1) summary
    cl14608
    Location:1130
    P53; P53 DNA-binding domain
  14. NM_001276760.2NP_001263689.1  cellular tumor antigen p53 isoform g

    See identical proteins and their annotated locations for NP_001263689.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (g, also known as delta40p53alpha or deltaNp53) results from translation initiation at the downstream start codon. It has a shorter N-terminus, compared to isoform a. Variants 1, 2, and 8 encode isoform g.
    Source sequence(s)
    AK223026, DA453049, DQ186650, X02469
    Consensus CDS
    CCDS73969.1
    UniProtKB/Swiss-Prot
    P04637
    UniProtKB/TrEMBL
    H2EHT1, Q53GA5
    Related
    ENSP00000481638.1, ENST00000620739.4
    Conserved Domains (2) summary
    pfam00870
    Location:56250
    P53; P53 DNA-binding domain
    pfam07710
    Location:280319
    P53_tetramer; P53 tetramerisation motif
  15. NM_001276761.2NP_001263690.1  cellular tumor antigen p53 isoform g

    See identical proteins and their annotated locations for NP_001263690.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. This variant can initiate translation from two in-frame AUG start codons. The isoform represented in this variant (g, also known as delta40p53alpha or deltaNp53) results from translation initiation at the downstream start codon. It has a shorter N-terminus, compared to isoform a. Variants 1, 2, and 8 encode isoform g.
    Source sequence(s)
    AB082923, AK223026, DA453049, DQ186650, X02469
    Consensus CDS
    CCDS73969.1
    UniProtKB/Swiss-Prot
    P04637
    UniProtKB/TrEMBL
    H2EHT1, Q53GA5
    Related
    ENSP00000482537.1, ENST00000619485.4
    Conserved Domains (2) summary
    pfam00870
    Location:56250
    P53; P53 DNA-binding domain
    pfam07710
    Location:280319
    P53_tetramer; P53 tetramerisation motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    7668402..7687550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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