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Trh thyrotropin releasing hormone [ Mus musculus (house mouse) ]

Gene ID: 22044, updated on 5-Jan-2023

Summary

Official Symbol
Trhprovided by MGI
Official Full Name
thyrotropin releasing hormoneprovided by MGI
Primary source
MGI:MGI:98823
See related
Ensembl:ENSMUSG00000005892 AllianceGenome:MGI:98823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trf; Pro-TRH
Summary
This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The mouse proprotein contains five thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Disruption of this gene results in hypothyroidism, elevated thyroid-stimulating hormone levels, and hyperglycemia. [provided by RefSeq, Apr 2013]
Expression
Biased expression in frontal lobe adult (RPKM 13.0), testis adult (RPKM 2.3) and 5 other tissues See more
Orthologs
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Genomic context

See Trh in Genome Data Viewer
Location:
6 D1; 6 41.03 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (92219042..92221631, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (92242061..92244650, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 2, group C, member 2 Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene rabenosyn, RAB effector Neighboring gene predicted gene, 30688 Neighboring gene predicted gene 44803 Neighboring gene prickle planar cell polarity protein 2 Neighboring gene predicted gene, 38862

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thyrotropin-releasing hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thyrotropin-releasing hormone activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adult walking behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in eating behavior IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in histamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glutamate secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of glutamate secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gamma-aminobutyric acid secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of gamma-aminobutyric acid secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
thyrotropin releasing hormone
Names
TSH-releasing factor
pro-thyrotropin-releasing hormone
prothyroliberin
protirelin
thyrotropin-releasing factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009426.3NP_033452.2  thyrotropin releasing hormone preproprotein

    See identical proteins and their annotated locations for NP_033452.2

    Status: REVIEWED

    Source sequence(s)
    AC164642, AI836004, AK010666, CF951860
    Consensus CDS
    CCDS20375.1
    UniProtKB/Swiss-Prot
    Q62361, Q7TMT4
    Related
    ENSMUSP00000006046.5, ENSMUST00000006046.5
    Conserved Domains (1) summary
    pfam05438
    Location:24223
    TRH; Thyrotropin-releasing hormone (TRH)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    92219042..92221631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)