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TRH thyrotropin releasing hormone [ Homo sapiens (human) ]

Gene ID: 7200, updated on 8-Jul-2021

Summary

Official Symbol
TRHprovided by HGNC
Official Full Name
thyrotropin releasing hormoneprovided by HGNC
Primary source
HGNC:HGNC:12298
See related
Ensembl:ENSG00000170893 MIM:613879
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRF; Pro-TRH
Summary
This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]
Expression
Biased expression in endometrium (RPKM 11.5), bone marrow (RPKM 1.1) and 1 other tissue See more
Orthologs
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Genomic context

See TRH in Genome Data Viewer
Location:
3q22.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (129974720..129977935)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (129693563..129696778)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domain family 1 Neighboring gene RNY3 pseudogene 13 Neighboring gene TMCC1 divergent transcript Neighboring gene ribosomal protein S17 pseudogene 9 Neighboring gene olfactory receptor family 7 subfamily E member 129 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125964, MGC125965

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thyrotropin-releasing hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in eating behavior IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of feeding behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of glutamate secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of gamma-aminobutyric acid secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of insulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to cold IEA
Inferred from Electronic Annotation
more info
 
involved_in response to corticosterone IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucose IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
thyrotropin releasing hormone
Names
TSH-releasing factor
pro-thyrotropin-releasing hormone
prothyroliberin
protirelin
thyrotropin-releasing factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027816.1 RefSeqGene

    Range
    5450..8665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007117.5NP_009048.1  thyrotropin releasing hormone preproprotein

    See identical proteins and their annotated locations for NP_009048.1

    Status: REVIEWED

    Source sequence(s)
    AC083906, AK313473
    Consensus CDS
    CCDS3066.1
    UniProtKB/Swiss-Prot
    P20396
    Related
    ENSP00000303452.3, ENST00000302649.4
    Conserved Domains (1) summary
    pfam05438
    Location:18203
    TRH; Thyrotropin-releasing hormone (TRH)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    129974720..129977935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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