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FCAR Fc fragment of IgA receptor [ Homo sapiens (human) ]

Gene ID: 2204, updated on 7-Dec-2018

Summary

Official Symbol
FCARprovided by HGNC
Official Full Name
Fc fragment of IgA receptorprovided by HGNC
Primary source
HGNC:HGNC:3608
See related
Ensembl:ENSG00000186431 MIM:147045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD89; FcalphaRI; CTB-61M7.2
Summary
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward bone marrow (RPKM 95.4) See more
Orthologs

Genomic context

See FCAR in Genome Data Viewer
Location:
19q13.42
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (54874093..54891420)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55385549..55401839)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2 Neighboring gene RNA, U6 small nuclear 222, pseudogene Neighboring gene natural cytotoxicity triggering receptor 1 Neighboring gene NLR family pyrin domain containing 7 Neighboring gene NLR family pyrin domain containing 2 Neighboring gene ribosomal protein L36a pseudogene 50

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Preincubation of monocytes with HIV-1 gp120 depresses anti-CD3 antibody-induced T cell stimulation and Fc receptor-mediated phagocytosis PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
    Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
  • Staphylococcus aureus infection, conserved biosystem (from KEGG)
    Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
IgA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
immune response TAS
Traceable Author Statement
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
immunoglobulin alpha Fc receptor
Names
FCAR variant 14
Fc alpha receptor
Fc fragment of IgA, receptor for

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002000.4NP_001991.1  immunoglobulin alpha Fc receptor isoform a precursor

    See identical proteins and their annotated locations for NP_001991.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as a.1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC245128, AK290922, BC027953
    Consensus CDS
    CCDS12907.1
    UniProtKB/Swiss-Prot
    P24071
    Related
    ENSP00000347714.3, ENST00000355524.7
    Conserved Domains (2) summary
    cd05711
    Location:125215
    Ig2_LILR_KIR_like; Second immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, natural and similar domains
    cd05751
    Location:27120
    Ig1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains
  2. NM_133269.3NP_579803.1  immunoglobulin alpha Fc receptor isoform b precursor

    See identical proteins and their annotated locations for NP_579803.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as a.2, delta66EC2, or U06) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC245128, AK290922, U43774
    Consensus CDS
    CCDS42622.1
    UniProtKB/Swiss-Prot
    P24071
    UniProtKB/TrEMBL
    A0A024R4N4
    Related
    ENSP00000375605.3, ENST00000391725.7
    Conserved Domains (1) summary
    cl11960
    Location:125197
    Ig; Immunoglobulin domain
  3. NM_133271.3NP_579805.1  immunoglobulin alpha Fc receptor isoform c precursor

    See identical proteins and their annotated locations for NP_579805.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as a.3, Rla2, deltaE2, or U08) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC245128, AK290922, S82919
    Consensus CDS
    CCDS12908.1
    UniProtKB/Swiss-Prot
    P24071
    Related
    ENSP00000338257.4, ENST00000345937.8
    Conserved Domains (1) summary
    cl11960
    Location:27120
    Ig; Immunoglobulin domain
  4. NM_133272.3NP_579806.1  immunoglobulin alpha Fc receptor isoform d

    See identical proteins and their annotated locations for NP_579806.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as deltaS2 or U11) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC245128, AK290922, D87855
    Consensus CDS
    CCDS12909.1
    UniProtKB/Swiss-Prot
    P24071
    Related
    ENSP00000352218.4, ENST00000359272.8
    Conserved Domains (2) summary
    cd05711
    Location:113203
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:15108
    Ig; Immunoglobulin domain
  5. NM_133273.3NP_579807.1  immunoglobulin alpha Fc receptor isoform e

    See identical proteins and their annotated locations for NP_579807.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as U10) lacks alternate in-frame exons in the 5' and 3' coding region, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    AC245128, AK290922, BC027953, BX643574
    Consensus CDS
    CCDS42624.1
    UniProtKB/Swiss-Prot
    P24071
    Related
    ENSP00000375606.3, ENST00000391726.7
    Conserved Domains (1) summary
    cl11960
    Location:15108
    Ig; Immunoglobulin domain
  6. NM_133274.3NP_579808.1  immunoglobulin alpha Fc receptor isoform f

    See identical proteins and their annotated locations for NP_579808.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as U09) lacks an in-frame exon in the 5' coding region and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (f) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC245128, AK290922, D87857
    Consensus CDS
    CCDS42625.1
    UniProtKB/Swiss-Prot
    P24071
    Related
    ENSP00000375603.3, ENST00000391723.7
    Conserved Domains (1) summary
    cl11960
    Location:113180
    Ig; Immunoglobulin domain
  7. NM_133277.3NP_579811.1  immunoglobulin alpha Fc receptor isoform g

    See identical proteins and their annotated locations for NP_579811.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7, also known as deltaS2ECl or L10) lacks two in-frame exons in the 5' coding region, compared to variant 1. The encoded isoform (g) is shorter than isoform a.
    Source sequence(s)
    AC245128, AK290922, D87861
    Consensus CDS
    CCDS12910.1
    UniProtKB/Swiss-Prot
    P24071
    Related
    ENSP00000338058.4, ENST00000353758.8
    Conserved Domains (1) summary
    cd05711
    Location:16106
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
  8. NM_133278.3NP_579812.1  immunoglobulin alpha Fc receptor isoform h

    See identical proteins and their annotated locations for NP_579812.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8, also known as deltaS266Ec2 or U13) lacks an in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (h) is shorter than isoform a.
    Source sequence(s)
    AC245128, AK290922, X92559
    Consensus CDS
    CCDS42623.1
    UniProtKB/Swiss-Prot
    P24071
    UniProtKB/TrEMBL
    A0A024R4R4
    Related
    ENSP00000375604.3, ENST00000391724.3
    Conserved Domains (1) summary
    cl11960
    Location:113185
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    54874093..54891420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526625.3XP_011524927.1  immunoglobulin alpha Fc receptor isoform X1

    See identical proteins and their annotated locations for XP_011524927.1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain
  2. XM_017026473.1XP_016881962.1  immunoglobulin alpha Fc receptor isoform X1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain
  3. XM_017026474.2XP_016881963.1  immunoglobulin alpha Fc receptor isoform X1

    Conserved Domains (2) summary
    cd05711
    Location:98188
    Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI
    cl11960
    Location:293
    Ig; Immunoglobulin domain

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_016107304.1 Reference GRCh38.p12 PATCHES

    Range
    203166..220493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_016107308.1 Reference GRCh38.p12 PATCHES

    Range
    96478..97751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 PATCHES

Genomic

  1. NW_016107312.1 Reference GRCh38.p12 PATCHES

    Range
    20566..37893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_2

Genomic

  1. NW_003571055.2 Reference GRCh38.p12 ALT_REF_LOCI_2

    Range
    519361..536649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p12 ALT_REF_LOCI_7

    Range
    778468..795785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p12 ALT_REF_LOCI_9

    Range
    856663..873900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_10

Genomic

  1. NT_187636.1 Reference GRCh38.p12 ALT_REF_LOCI_10

    Range
    152..1425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_15

Genomic

  1. NT_187641.1 Reference GRCh38.p12 ALT_REF_LOCI_15

    Range
    10..7021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001756533.1 RNA Sequence

Reference GRCh38.p12 ALT_REF_LOCI_23

Genomic

  1. NT_187671.1 Reference GRCh38.p12 ALT_REF_LOCI_23

    Range
    153040..170367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_26

Genomic

  1. NT_187674.1 Reference GRCh38.p12 ALT_REF_LOCI_26

    Range
    160113..177440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_27

Genomic

  1. NT_187675.1 Reference GRCh38.p12 ALT_REF_LOCI_27

    Range
    244332..261659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_28

Genomic

  1. NT_187676.1 Reference GRCh38.p12 ALT_REF_LOCI_28

    Range
    150043..167370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_29

Genomic

  1. NT_187677.1 Reference GRCh38.p12 ALT_REF_LOCI_29

    Range
    151460..168787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_30

Genomic

  1. NT_187683.1 Reference GRCh38.p12 ALT_REF_LOCI_30

    Range
    148311..165638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_133279.2: Suppressed sequence

    Description
    NM_133279.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_133280.1: Suppressed sequence

    Description
    NM_133280.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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