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Traip TRAF-interacting protein [ Mus musculus (house mouse) ]

Gene ID: 22036, updated on 12-May-2024

Summary

Official Symbol
Traipprovided by MGI
Official Full Name
TRAF-interacting proteinprovided by MGI
Primary source
MGI:MGI:1096377
See related
Ensembl:ENSMUSG00000032586 AllianceGenome:MGI:1096377
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trip
Summary
Enables ubiquitin protein ligase activity. Involved in negative regulation of interferon-beta production and protein ubiquitination. Acts upstream of or within negative regulation of NF-kappaB transcription factor activity and signal transduction. Predicted to be located in nucleolus; nucleoplasm; and site of DNA damage. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina layer; and spleen. Human ortholog(s) of this gene implicated in Seckel syndrome 9. Orthologous to human TRAIP (TRAF interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 3.7), frontal lobe adult (RPKM 3.7) and 19 other tissues See more
Orthologs
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Genomic context

Location:
9 F1; 9 59.07 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107828158..107849469)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107950325..107972270)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene actin-like 11 Neighboring gene CaM kinase-like vesicle-associated Neighboring gene STARR-positive B cell enhancer ABC_E3858 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107878063-107878250 Neighboring gene STARR-positive B cell enhancer ABC_E2913 Neighboring gene ubiquitin-like modifier activating enzyme 7 Neighboring gene inka box actin regulator 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in site of DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRAIP
Names
RING-type E3 ubiquitin transferase TRAIP
NP_001397399.1
NP_001397400.1
NP_001397401.1
NP_001397402.1
NP_035764.2
XP_017168773.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410470.1NP_001397399.1  E3 ubiquitin-protein ligase TRAIP isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL731808
  2. NM_001410471.1NP_001397400.1  E3 ubiquitin-protein ligase TRAIP isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL731808
  3. NM_001410472.1NP_001397401.1  E3 ubiquitin-protein ligase TRAIP isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL731808
  4. NM_001410473.1NP_001397402.1  E3 ubiquitin-protein ligase TRAIP isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL731808
  5. NM_011634.4NP_035764.2  E3 ubiquitin-protein ligase TRAIP isoform 1

    See identical proteins and their annotated locations for NP_035764.2

    Status: VALIDATED

    Source sequence(s)
    AL731808
    Consensus CDS
    CCDS23511.1
    UniProtKB/Swiss-Prot
    O08854, Q8VIG6, Q922M8, Q9CPP4
    Related
    ENSMUSP00000040001.4, ENSMUST00000049348.9
    Conserved Domains (2) summary
    pfam08647
    Location:204271
    BRE1; BRE1 E3 ubiquitin ligase
    pfam13639
    Location:750
    zf-RING_2; Ring finger domain

RNA

  1. NR_177076.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL731808

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107828158..107849469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313284.2XP_017168773.1  E3 ubiquitin-protein ligase TRAIP isoform X2

    Conserved Domains (1) summary
    COG1196
    Location:6150
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]