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TRAIP TRAF interacting protein [ Homo sapiens (human) ]

Gene ID: 10293, updated on 5-Aug-2022

Summary

Official Symbol
TRAIPprovided by HGNC
Official Full Name
TRAF interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:30764
See related
Ensembl:ENSG00000183763 MIM:605958; AllianceGenome:HGNC:30764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRIP; SCKL9; RNF206
Summary
This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 4.0), bone marrow (RPKM 2.3) and 23 other tissues See more
Orthologs
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Genomic context

See TRAIP in Genome Data Viewer
Location:
3p21.31
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (49828601..49856564, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (49858496..49886461, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49866034..49893997, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10954 Neighboring gene inka box actin regulator 1 Neighboring gene microRNA 5193 Neighboring gene ubiquitin like modifier activating enzyme 7 Neighboring gene CaM kinase like vesicle associated Neighboring gene RNA, 7SL, cytoplasmic 217, pseudogene Neighboring gene actin like 11, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in site of DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in site of DNA damage IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRAIP
Names
RING-type E3 ubiquitin transferase TRAIP
ring finger protein 206
NP_005870.2
XP_016861015.1
XP_047303196.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046695.1 RefSeqGene

    Range
    4996..32959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005879.3NP_005870.2  E3 ubiquitin-protein ligase TRAIP

    See identical proteins and their annotated locations for NP_005870.2

    Status: REVIEWED

    Source sequence(s)
    AC139451, BC019283, BQ446539, BX473682
    Consensus CDS
    CCDS2806.1
    UniProtKB/Swiss-Prot
    O00467, Q9BWF2
    Related
    ENSP00000328203.2, ENST00000331456.7
    Conserved Domains (2) summary
    cd16480
    Location:650
    RING-H2_TRAIP; RING finger, H2 subclass, found in TRAF-interacting protein (TRAIP) and similar proteins
    cl25732
    Location:68279
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    49828601..49856564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005526.2XP_016861015.1  E3 ubiquitin-protein ligase TRAIP isoform X1

  2. XM_047447240.1XP_047303196.1  E3 ubiquitin-protein ligase TRAIP isoform X2

RNA

  1. XR_007094382.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    49858496..49886461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)