Format

Send to:

Choose Destination

TRAIP TRAF interacting protein [ Homo sapiens (human) ]

Gene ID: 10293, updated on 24-Nov-2020

Summary

Official Symbol
TRAIPprovided by HGNC
Official Full Name
TRAF interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:30764
See related
Ensembl:ENSG00000183763 MIM:605958
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRIP; SCKL9; RNF206
Summary
This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 4.0), bone marrow (RPKM 2.3) and 23 other tissues See more
Orthologs

Genomic context

See TRAIP in Genome Data Viewer
Location:
3p21.31
Exon count:
16
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (49828595..49856584, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49866028..49893992, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene inka box actin regulator 1 Neighboring gene microRNA 5193 Neighboring gene ubiquitin like modifier activating enzyme 7 Neighboring gene CaM kinase like vesicle associated Neighboring gene RNA, 7SL, cytoplasmic 217, pseudogene Neighboring gene actin like 11, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interferon-beta production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein-DNA covalent cross-linking repair ISS
Inferred from Sequence or Structural Similarity
more info
 
replication fork processing IDA
Inferred from Direct Assay
more info
PubMed 
replication fork processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
site of DNA damage IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRAIP
Names
RING-type E3 ubiquitin transferase TRAIP
ring finger protein 206
NP_005870.2
XP_011531566.1
XP_016861015.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046695.1 RefSeqGene

    Range
    4996..32959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005879.3NP_005870.2  E3 ubiquitin-protein ligase TRAIP

    See identical proteins and their annotated locations for NP_005870.2

    Status: REVIEWED

    Source sequence(s)
    AC139451, BC019283, BQ446539, BX473682
    Consensus CDS
    CCDS2806.1
    UniProtKB/Swiss-Prot
    Q9BWF2
    Related
    ENSP00000328203.2, ENST00000331456.7
    Conserved Domains (2) summary
    cd16480
    Location:650
    RING-H2_TRAIP; RING finger, H2 subclass, found in TRAF-interacting protein (TRAIP) and similar proteins
    cl25732
    Location:68279
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    49828595..49856584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005526.1XP_016861015.1  E3 ubiquitin-protein ligase TRAIP isoform X2

  2. XM_011533264.1XP_011531566.1  E3 ubiquitin-protein ligase TRAIP isoform X1

    Conserved Domains (1) summary
    COG1196
    Location:17202
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. XR_001739979.1 RNA Sequence

Support Center