Format

Send to:

Choose Destination

FBP1 fructose-bisphosphatase 1 [ Homo sapiens (human) ]

Gene ID: 2203, updated on 11-Jun-2021

Summary

Official Symbol
FBP1provided by HGNC
Official Full Name
fructose-bisphosphatase 1provided by HGNC
Primary source
HGNC:HGNC:3606
See related
Ensembl:ENSG00000165140 MIM:611570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBP
Summary
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 175.9), kidney (RPKM 118.4) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See FBP1 in Genome Data Viewer
Location:
9q22.32
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (94603133..94640263, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (97365415..97402545, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987100 Neighboring gene leishmanolysin like peptidase pseudogene Neighboring gene RNA, U6 small nuclear 669, pseudogene Neighboring gene prostate cancer associated transcript 7 Neighboring gene fructose-bisphosphatase 2 Neighboring gene uncharacterized LOC107987101 Neighboring gene aminopeptidase O (putative) Neighboring gene microRNA 2278

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Fructose-biphosphatase deficiency not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 Matrix activates fructose 1,6-bisphosphatase gene expression by induction of a 1alpha-hydroxylase activity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables AMP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables fructose 1,6-bisphosphate 1-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fructose 1,6-bisphosphate 1-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fructose 1,6-bisphosphate 1-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables monosaccharide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to drug IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to magnesium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fructose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fructose 6-phosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fructose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in gluconeogenesis TAS
Traceable Author Statement
more info
 
involved_in negative regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sucrose biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
fructose-1,6-bisphosphatase 1
Names
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1
FBPase 1
growth-inhibiting protein 17
liver FBPase
NP_000498.2
NP_001121100.1
XP_006717068.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008174.1 RefSeqGene

    Range
    5001..42117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000507.4NP_000498.2  fructose-1,6-bisphosphatase 1

    See identical proteins and their annotated locations for NP_000498.2

    Status: REVIEWED

    Source sequence(s)
    BC012927, DA962803
    Consensus CDS
    CCDS6712.1
    UniProtKB/Swiss-Prot
    P09467
    Related
    ENSP00000364475.5, ENST00000375326.9
    Conserved Domains (1) summary
    cd00354
    Location:18332
    FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...
  2. NM_001127628.2NP_001121100.1  fructose-1,6-bisphosphatase 1

    See identical proteins and their annotated locations for NP_001121100.1

    Status: REVIEWED

    Source sequence(s)
    AL161728
    Consensus CDS
    CCDS6712.1
    UniProtKB/Swiss-Prot
    P09467
    UniProtKB/TrEMBL
    Q2TU34
    Related
    ENSP00000408025.1, ENST00000415431.5
    Conserved Domains (1) summary
    cd00354
    Location:18332
    FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    94603133..94640263 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717005.4XP_006717068.1  fructose-1,6-bisphosphatase 1 isoform X1

    Conserved Domains (1) summary
    cd00354
    Location:2250
    FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...
Support Center