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Hsp90b1 heat shock protein 90, beta (Grp94), member 1 [ Mus musculus (house mouse) ]

Gene ID: 22027, updated on 12-May-2024

Summary

Official Symbol
Hsp90b1provided by MGI
Official Full Name
heat shock protein 90, beta (Grp94), member 1provided by MGI
Primary source
MGI:MGI:98817
See related
Ensembl:ENSMUSG00000020048 AllianceGenome:MGI:98817
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TA-3; Tra1; gp96; ERp99; GRP94; Targ2; Tra-1; endoplasmin
Summary
Predicted to enable several functions, including low-density lipoprotein particle receptor binding activity; protein phosphatase binding activity; and unfolded protein binding activity. Predicted to be involved in protein folding and ubiquitin-dependent ERAD pathway. Predicted to act upstream of or within actin rod assembly; cellular response to ATP; and regulation of phosphoprotein phosphatase activity. Located in endoplasmic reticulum and plasma membrane. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including brain; integument; lung; metanephros; and pancreas. Orthologous to several human genes including HSP90B1 (heat shock protein 90 beta family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 303.0), CNS E11.5 (RPKM 168.9) and 20 other tissues See more
Orthologs
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Genomic context

See Hsp90b1 in Genome Data Viewer
Location:
10 C1; 10 43.05 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (86526705..86541308, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (86690841..86705444, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5174 Neighboring gene STARR-seq mESC enhancer starr_27466 Neighboring gene RIKEN cDNA 1810014B01 gene Neighboring gene STARR-seq mESC enhancer starr_27467 Neighboring gene tetratricopeptide repeat domain 41 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:86190323-86190623 Neighboring gene STARR-positive B cell enhancer ABC_E11451 Neighboring gene fatty acid binding protein 3, muscle and heart, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_27469 Neighboring gene STARR-positive B cell enhancer mm9_chr10:86240990-86241290 Neighboring gene STARR-positive B cell enhancer mm9_chr10:86241543-86241844 Neighboring gene 5'-nucleotidase domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E8356

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (8)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within actin rod assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cellular response to ATP ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in insulin processing ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of endoplasmic reticulum chaperone complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in sperm plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
endoplasmin
Names
94 kDa glucose-regulated protein
endoplasmic reticulum resident protein 99
heat shock protein 90 kDa beta member 1
polymorphic tumor rejection antigen 1
transforming growth factor alpha regulated gene 2
tumor rejection antigen (gp96) 1
tumor rejection antigen gp96

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011631.1NP_035761.1  endoplasmin precursor

    Status: PROVISIONAL

    Source sequence(s)
    J03297
    Consensus CDS
    CCDS36019.1
    UniProtKB/Swiss-Prot
    P08113, P11427
    UniProtKB/TrEMBL
    Q3UAD6, Q91V38
    Related
    ENSMUSP00000020238.8, ENSMUST00000020238.14
    Conserved Domains (3) summary
    smart00387
    Location:96254
    HATPase_c; Histidine kinase-like ATPases
    PRK05218
    Location:74746
    PRK05218; heat shock protein 90; Provisional
    pfam00183
    Location:257783
    HSP90; Hsp90 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    86526705..86541308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)