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HSP90B1 heat shock protein 90 beta family member 1 [ Homo sapiens (human) ]

Gene ID: 7184, updated on 20-Sep-2020

Summary

Official Symbol
HSP90B1provided by HGNC
Official Full Name
heat shock protein 90 beta family member 1provided by HGNC
Primary source
HGNC:HGNC:12028
See related
Ensembl:ENSG00000166598 MIM:191175
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ECGP; GP96; TRA1; GRP94; HEL35; HEL-S-125m
Summary
This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in thyroid (RPKM 807.9), appendix (RPKM 260.4) and 24 other tissues See more
Orthologs

Genomic context

See HSP90B1 in Genome Data Viewer
Location:
12q23.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (103930410..103947926)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (104324112..104341708)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984433 Neighboring gene tetratricopeptide repeat domain 41, pseudogene Neighboring gene uncharacterized LOC107984130 Neighboring gene microRNA 3652 Neighboring gene chromosome 12 open reading frame 73 Neighboring gene thymine DNA glycosylase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Two-marker association tests yield new disease associations for coronary artery disease and hypertension.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with HSP90B1; predicted interaction to be within the endoplasmic reticulum and function as chaperone for endoplasmic reticulum-associated degradation PubMed
Nef nef Genome-wide shRNA screening identifies HSP90B1, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
nef Microvesicles, which contaminate purified HIV-1 inocula due to similar size and density, contain viral protein Nef and cellular proteins HSP90alpha and HSP90beta that are capable of potent stimulation of dendritic cells maturation and ICAM-1 expression PubMed
Rev rev HIV-1 Rev interacting protein, heat shock protein 90kDa beta (HSP90B1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HSP90B1 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
low-density lipoprotein particle receptor binding IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
ATF6-mediated unfolded protein response TAS
Traceable Author Statement
more info
 
actin rod assembly IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to ATP IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein folding in endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
protein transport NAS
Non-traceable Author Statement
more info
PubMed 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 
regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
response to endoplasmic reticulum stress TAS
Traceable Author Statement
more info
PubMed 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
retrograde protein transport, ER to cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
sequestering of calcium ion NAS
Non-traceable Author Statement
more info
PubMed 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endocytic vesicle lumen TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum chaperone complex IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
focal adhesion HDA PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 
perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
sarcoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
endoplasmin
Names
94 kDa glucose-regulated protein
endothelial cell (HBMEC) glycoprotein
epididymis luminal protein 35
epididymis secretory sperm binding protein Li 125m
heat shock protein 90 kDa beta member 1
heat shock protein 90kDa beta (Grp94), member 1
heat shock protein 90kDa beta family member 1
stress-inducible tumor rejection antigen gp96
tumor rejection antigen (gp96) 1
tumor rejection antigen 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003299.3NP_003290.1  endoplasmin precursor

    See identical proteins and their annotated locations for NP_003290.1

    Status: REVIEWED

    Source sequence(s)
    AC078819, CA419931, X15187
    Consensus CDS
    CCDS9094.1
    UniProtKB/Swiss-Prot
    P14625
    UniProtKB/TrEMBL
    V9HWP2
    Related
    ENSP00000299767.4, ENST00000299767.10
    Conserved Domains (2) summary
    pfam00183
    Location:257755
    HSP90; Hsp90 protein
    cl27733
    Location:77464
    HSP90; Hsp90 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    103930410..103947926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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