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Tpst1 protein-tyrosine sulfotransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 22021, updated on 2-Nov-2024

Summary

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Official Symbol
Tpst1provided by MGI
Official Full Name
protein-tyrosine sulfotransferase 1provided by MGI
Primary source
MGI:MGI:1298231
See related
Ensembl:ENSMUSG00000034118 AllianceGenome:MGI:1298231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tango13a
Summary
Enables protein-tyrosine sulfotransferase activity. Involved in peptidyl-tyrosine sulfation and post-translational protein modification. Is active in Golgi lumen and trans-Golgi network. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human TPST1 (tyrosylprotein sulfotransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 26.6), testis adult (RPKM 22.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tpst1 in Genome Data Viewer
Location:
5 G1.3; 5 68.53 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (130102167..130164575)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (130073326..130135734)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40334 Neighboring gene calcitonin gene-related peptide-receptor component protein Neighboring gene STARR-positive B cell enhancer ABC_E3625 Neighboring gene STARR-positive B cell enhancer ABC_E1690 Neighboring gene predicted gene, 54305 Neighboring gene STARR-positive B cell enhancer ABC_E233 Neighboring gene potassium channel tetramerisation domain containing 7 Neighboring gene STARR-seq mESC enhancer starr_14469 Neighboring gene STARR-positive B cell enhancer ABC_E3626 Neighboring gene RAB guanine nucleotide exchange factor (GEF) 1 Neighboring gene STARR-seq mESC enhancer starr_14471 Neighboring gene NADH:ubiquinone oxidoreductase subunit A12, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reduced body weight and increased postimplantation fetal death in tyrosylprotein sulfotransferase-1-deficient mice. Ouyang YB, et al. J Biol Chem, 2002 Jun 28. PMID 11964405
  2. Salivary gland hypofunction in tyrosylprotein sulfotransferase-2 knockout mice is due to primary hypothyroidism. Westmuckett AD, et al. PLoS One, 2013. PMID 23951251, Free PMC Article
  3. Tyrosine sulfation is a trans-Golgi-specific protein modification. Baeuerle PA, et al. J Cell Biol, 1987 Dec. PMID 3121635, Free PMC Article
  4. Early postnatal pulmonary failure and primary hypothyroidism in mice with combined TPST-1 and TPST-2 deficiency. Westmuckett AD, et al. Gen Comp Endocrinol, 2008 Mar 1. PMID 18243191, Free PMC Article
  5. Tyrosylprotein sulfotransferase-2 expression is required for sulfation of RNase 9 and Mfge8 in vivo. Hoffhines AJ, et al. J Biol Chem, 2009 Jan 30. PMID 19047058, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results demonstrate the importance of protein-tyrosine sulfation for proper development of the retina and suggest different phenotypes resulting from elimination of TPST-1 or -2 may reflect differential expression patterns or levels of the enzymes.
    Title: Differential developmental deficits in retinal function in the absence of either protein tyrosine sulfotransferase-1 or -2.
  2. two genes identified in this analysis, PLEC1 and TPST1, reduced IL-6 production by macrophages
    Title: Identification of novel innate immune genes by transcriptional profiling of macrophages stimulated with TLR ligands.
  3. Data show that Tpst1/Tpst2 DKO leukocytes bound less P-selectin than wild type leukocytes despite equivalent surface expression of Psgl-1.
    Title: Tyrosine sulfation of native mouse Psgl-1 is required for optimal leukocyte rolling on P-selectin in vivo.
  4. These results indicate that protein-tyrosine sulfation by Tpst1/2 is essential for proper outer segment morphogenesis and synaptic function, but is not critical for overall retinal structure or synapse formation.
    Title: Lack of protein-tyrosine sulfation disrupts photoreceptor outer segment morphogenesis, retinal function and retinal anatomy.
  5. Tpst1 and Tpst2 are the only Tpst genes in mice, tyrosine sulfation is required for normal pulmonary function at birth, and TPST-2 is required for normal thyroid gland function.
    Title: Early postnatal pulmonary failure and primary hypothyroidism in mice with combined TPST-1 and TPST-2 deficiency.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-tyrosine sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-tyrosine sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-tyrosine sulfotransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-tyrosine sulfotransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in peptidyl-tyrosine sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-tyrosine sulfation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidyl-tyrosine sulfation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-translational protein modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in post-translational protein modification ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi lumen IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi lumen ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
protein-tyrosine sulfotransferase 1
Names
TPST-1
tyrosylprotein sulfotransferase 1
NP_001123948.1
NP_038865.1
XP_006504481.1
XP_036020889.1
XP_036020890.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130476.2 → NP_001123948.1  protein-tyrosine sulfotransferase 1

    See identical proteins and their annotated locations for NP_001123948.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI183198, AK150753, CJ046784
    Consensus CDS
    CCDS39293.1
    UniProtKB/Swiss-Prot
    O70281
    UniProtKB/TrEMBL
    Q4FK50
    Related
    ENSMUSP00000035614.9, ENSMUST00000040721.9
    Conserved Domains (1) summary
    pfam13469
    Location:72 → 261
    Sulfotransfer_3; Sulfotransferase family

  2. NM_013837.2 → NP_038865.1  protein-tyrosine sulfotransferase 1

    See identical proteins and their annotated locations for NP_038865.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF038008, AI183198
    Consensus CDS
    CCDS39293.1
    UniProtKB/Swiss-Prot
    O70281
    UniProtKB/TrEMBL
    Q4FK50
    Related
    ENSMUSP00000112571.2, ENSMUST00000118993.8
    Conserved Domains (1) summary
    pfam13469
    Location:72 → 261
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    130102167..130164575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164996.1 → XP_036020889.1  protein-tyrosine sulfotransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O70281
    UniProtKB/TrEMBL
    Q4FK50
    Conserved Domains (1) summary
    pfam13469
    Location:72 → 261
    Sulfotransfer_3; Sulfotransferase family

  2. XM_036164997.1 → XP_036020890.1  protein-tyrosine sulfotransferase 1 isoform X2

    Conserved Domains (1) summary
    pfam13469
    Location:72 → 261
    Sulfotransfer_3; Sulfotransferase family

  3. XM_006504418.3 → XP_006504481.1  protein-tyrosine sulfotransferase 1 isoform X2

    Conserved Domains (1) summary
    pfam13469
    Location:72 → 261
    Sulfotransfer_3; Sulfotransferase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70281.1 GenPept UniProtKB/Swiss-Prot:O70281

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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