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TPST1 tyrosylprotein sulfotransferase 1 [ Homo sapiens (human) ]

Gene ID: 8460, updated on 22-Sep-2022

Summary

Official Symbol
TPST1provided by HGNC
Official Full Name
tyrosylprotein sulfotransferase 1provided by HGNC
Primary source
HGNC:HGNC:12020
See related
Ensembl:ENSG00000169902 MIM:603125; AllianceGenome:HGNC:12020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TANGO13A
Summary
Enables protein homodimerization activity and protein-tyrosine sulfotransferase activity. Involved in peptidyl-tyrosine sulfation. Is integral component of Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in gall bladder (RPKM 13.2), urinary bladder (RPKM 9.5) and 22 other tissues See more
Orthologs
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Genomic context

See TPST1 in Genome Data Viewer
Location:
7q11.21
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (66198790..66360443)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (67427424..67582531)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (65670321..65825430)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11837 Neighboring gene argininosuccinate lyase Neighboring gene CGRP receptor component Neighboring gene RNA, U6 small nuclear 313, pseudogene Neighboring gene long intergenic non-protein coding RNA 174 Neighboring gene U6 spliceosomal RNA Neighboring gene general transcription factor IIi pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The chemokine receptor CCR5 is posttranslationally modified by sulfation of its N-terminal tyrosines; sulfated tyrosines contribute to the binding of CCR5 to MIP-1 alpha, MIP-1 beta, and HIV-1 gp120/CD4 complexes and to the ability of HIV-1 to enter cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-tyrosine sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-tyrosine sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-tyrosine sulfotransferase activity TAS
Traceable Author Statement
more info
 
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
Traceable Author Statement
more info
 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in peptidyl-tyrosine sulfation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-tyrosine sulfation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine sulfation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
protein-tyrosine sulfotransferase 1
Names
TPST-1
transport and golgi organization 13 homolog A
NP_003587.1
XP_005250699.1
XP_011514936.1
XP_011514937.1
XP_016868215.1
XP_016868216.1
XP_047276912.1
XP_047276913.1
XP_047276914.1
XP_047276915.1
XP_047276916.1
XP_047276918.1
XP_047276919.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003596.4NP_003587.1  protein-tyrosine sulfotransferase 1

    See identical proteins and their annotated locations for NP_003587.1

    Status: VALIDATED

    Source sequence(s)
    BC013188
    Consensus CDS
    CCDS5533.1
    UniProtKB/Swiss-Prot
    O60507, Q6FGM7
    UniProtKB/TrEMBL
    A0A024RDK9
    Related
    ENSP00000302413.5, ENST00000304842.6
    Conserved Domains (1) summary
    pfam13469
    Location:72261
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    66198790..66360443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420959.1XP_047276915.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q6FGM7
    UniProtKB/TrEMBL
    A0A024RDK9
  2. XM_047420957.1XP_047276913.1  protein-tyrosine sulfotransferase 1 isoform X1

  3. XM_047420960.1XP_047276916.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q6FGM7
    UniProtKB/TrEMBL
    A0A024RDK9
  4. XM_047420962.1XP_047276918.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q6FGM7
    UniProtKB/TrEMBL
    A0A024RDK9
  5. XM_047420958.1XP_047276914.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q6FGM7
    UniProtKB/TrEMBL
    A0A024RDK9
  6. XM_017012726.3XP_016868215.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    O60507, Q6FGM7
    UniProtKB/TrEMBL
    A0A024RDK9
    Conserved Domains (1) summary
    pfam13469
    Location:72261
    Sulfotransfer_3; Sulfotransferase family
  7. XM_017012727.3XP_016868216.1  protein-tyrosine sulfotransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    O60507, Q6FGM7
    UniProtKB/TrEMBL
    A0A024RDK9
    Conserved Domains (1) summary
    pfam13469
    Location:72261
    Sulfotransfer_3; Sulfotransferase family
  8. XM_011516635.4XP_011514937.1  protein-tyrosine sulfotransferase 1 isoform X3

    See identical proteins and their annotated locations for XP_011514937.1

    Conserved Domains (1) summary
    pfam13469
    Location:72261
    Sulfotransfer_3; Sulfotransferase family
  9. XM_047420963.1XP_047276919.1  protein-tyrosine sulfotransferase 1 isoform X3

  10. XM_011516634.4XP_011514936.1  protein-tyrosine sulfotransferase 1 isoform X3

    See identical proteins and their annotated locations for XP_011514936.1

    Conserved Domains (1) summary
    pfam13469
    Location:72261
    Sulfotransfer_3; Sulfotransferase family
  11. XM_005250642.4XP_005250699.1  protein-tyrosine sulfotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005250699.1

    Conserved Domains (1) summary
    pfam13469
    Location:69257
    Sulfotransfer_3; Sulfotransferase family
  12. XM_047420956.1XP_047276912.1  protein-tyrosine sulfotransferase 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    67427424..67582531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)