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DOK6 docking protein 6 [ Homo sapiens (human) ]

Gene ID: 220164, updated on 22-Aug-2020

Summary

Official Symbol
DOK6provided by HGNC
Official Full Name
docking protein 6provided by HGNC
Primary source
HGNC:HGNC:28301
See related
Ensembl:ENSG00000206052 MIM:611402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOK5L; HsT3226
Summary
DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in brain (RPKM 6.3), kidney (RPKM 1.5) and 10 other tissues See more
Orthologs

Genomic context

See DOK6 in Genome Data Viewer
Location:
18q22.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (69400888..69849087)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (67068284..67516323)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985135 Neighboring gene uncharacterized LOC107985136 Neighboring gene uncharacterized LOC105372179 Neighboring gene uncharacterized LOC105372178 Neighboring gene uncharacterized LOC107985138 Neighboring gene CD226 molecule Neighboring gene rotatin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.
GeneReviews: Not available
Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of docking protein 6 (DOK6) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC20785

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
axon guidance TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
docking protein 6
Names
downstream of tyrosine kinase 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152721.6NP_689934.2  docking protein 6

    See identical proteins and their annotated locations for NP_689934.2

    Status: VALIDATED

    Source sequence(s)
    AC026585, AC090231, AY599248, BC008583, BC019045, BX280184, DB480182
    Consensus CDS
    CCDS32841.1
    UniProtKB/Swiss-Prot
    Q6PKX4
    Related
    ENSP00000372160.5, ENST00000382713.10
    Conserved Domains (2) summary
    cd13164
    Location:133235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    69400888..69849087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525875.2XP_011524177.1  docking protein 6 isoform X1

    See identical proteins and their annotated locations for XP_011524177.1

    Conserved Domains (2) summary
    cd13164
    Location:133235
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
    cd14678
    Location:9113
    PH_DOK4_DOK5_DOK6; Pleckstrin homology (PH) domain of Downstream of tyrosine kinase 4, 5, and 6 proteins
  2. XM_017025610.1XP_016881099.1  docking protein 6 isoform X2

    Conserved Domains (1) summary
    cd13164
    Location:25127
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
  3. XM_017025611.1XP_016881100.1  docking protein 6 isoform X2

    Conserved Domains (1) summary
    cd13164
    Location:25127
    PTB_DOK4_DOK5_DOK6; Downstream of tyrosine kinase 4, 5, and 6 proteins phosphotyrosine-binding domain (PTBi)
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