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Top2b topoisomerase (DNA) II beta [ Mus musculus (house mouse) ]

Gene ID: 21974, updated on 9-May-2024

Summary

Official Symbol
Top2bprovided by MGI
Official Full Name
topoisomerase (DNA) II betaprovided by MGI
Primary source
MGI:MGI:98791
See related
Ensembl:ENSMUSG00000017485 AllianceGenome:MGI:98791
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Top-2; D230016L12Rik
Summary
Predicted to enable several functions, including enzyme binding activity; protein C-terminus binding activity; and protein heterodimerization activity. Acts upstream of or within axonogenesis; forebrain development; and neuron migration. Located in nucleus. Is expressed in central nervous system; genitourinary system; and retina. Orthologous to human TOP2B (DNA topoisomerase II beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 40.7), CNS E14 (RPKM 36.8) and 22 other tissues See more
Orthologs
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Genomic context

See Top2b in Genome Data Viewer
Location:
14 A1; 14 7.08 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (6038976..6104585, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (16365206..16430787)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene retinoic acid receptor, beta Neighboring gene ATP-binding cassette, sub-family E (OABP), member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36026 Neighboring gene predicted gene, 53820 Neighboring gene predicted gene, 46442 Neighboring gene STARR-seq mESC enhancer starr_36025 Neighboring gene STARR-positive B cell enhancer ABC_E1166 Neighboring gene STARR-seq mESC enhancer starr_36024 Neighboring gene STARR-seq mESC enhancer starr_36023 Neighboring gene STARR-seq mESC enhancer starr_36022 Neighboring gene N-glycanase 1 Neighboring gene ribosomal protein L31, pseudogene 3 Neighboring gene 3-oxoacyl-ACP synthase, mitochondrial

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA topoisomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
NOT located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA topoisomerase 2-beta
Names
DNA topoisomerase II, beta isozyme
NP_033435.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009409.3NP_033435.2  DNA topoisomerase 2-beta

    See identical proteins and their annotated locations for NP_033435.2

    Status: VALIDATED

    Source sequence(s)
    AC154452, AC154471
    Consensus CDS
    CCDS26833.1
    UniProtKB/Swiss-Prot
    Q64511, Q7TQG4
    Related
    ENSMUSP00000017629.5, ENSMUST00000017629.12
    Conserved Domains (8) summary
    cd03365
    Location:464584
    TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
    PHA03151
    Location:13441582
    PHA03151; hypothetical protein; Provisional
    cd00187
    Location:7201180
    TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
    cd03481
    Location:274426
    TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
    PTZ00108
    Location:341457
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam02518
    Location:89186
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    pfam08070
    Location:14951596
    DTHCT; DTHCT (NUC029) region
    pfam16898
    Location:582720
    TOPRIM_C; C-terminal associated domain of TOPRIM

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    6038976..6104585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)