U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cd27 CD27 antigen [ Mus musculus (house mouse) ]

Gene ID: 21940, updated on 8-Feb-2024

Summary

Official Symbol
Cd27provided by MGI
Official Full Name
CD27 antigenprovided by MGI
Primary source
MGI:MGI:88326
See related
Ensembl:ENSMUSG00000030336 AllianceGenome:MGI:88326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S152; Tp55; Tnfrsf7
Summary
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in negative regulation of apoptotic process and positive regulation of JNK cascade. Acts upstream of or within negative regulation of T cell apoptotic process. Located in external side of plasma membrane. Is expressed in several structures, including femur; hemolymphoid system; intestine; pituitary gland; and reproductive system. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 2. Orthologous to human CD27 (CD27 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 190.8), spleen adult (RPKM 23.5) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cd27 in Genome Data Viewer
Location:
6 F3; 6 59.32 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (125209583..125214014, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125232620..125237136, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1712 Neighboring gene vesicle-associated membrane protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:125172222-125172506 Neighboring gene TAP binding protein-like Neighboring gene RIKEN cDNA E130112N10 gene Neighboring gene STARR-positive B cell enhancer ABC_E6490 Neighboring gene microRNA 8113 Neighboring gene predicted gene, 53066 Neighboring gene predicted gene, 24175

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CD27 antigen
Names
CD antigen 27
CD27L receptor
T-cell activation antigen CD27
tumor necrosis factor receptor superfamily member 7

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033126.2NP_001028298.1  CD27 antigen isoform a precursor

    See identical proteins and their annotated locations for NP_001028298.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AA475779, AC140324, AI326735, DT924276
    Consensus CDS
    CCDS39639.1
    UniProtKB/Swiss-Prot
    P41272
    UniProtKB/TrEMBL
    Q3U4X0
    Related
    ENSMUSP00000032486.7, ENSMUST00000032486.13
    Conserved Domains (1) summary
    cd13408
    Location:4123
    TNFRSF7; Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), also known as CD27
  2. NM_001042564.1NP_001036029.1  CD27 antigen isoform b precursor

    See identical proteins and their annotated locations for NP_001036029.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. It encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    AC140324, AI326735, BE631582
    Consensus CDS
    CCDS39638.1
    UniProtKB/TrEMBL
    B7ZW87
    Related
    ENSMUSP00000107901.3, ENSMUST00000112282.3
    Conserved Domains (1) summary
    cl22855
    Location:445
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  3. NM_001286753.1NP_001273682.1  CD27 antigen isoform c precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform c, which is shorter than isoform a.
    Source sequence(s)
    AC140324, AI326735, DT924276
    Consensus CDS
    CCDS71839.1
    UniProtKB/TrEMBL
    D3Z7W5
    Related
    ENSMUSP00000107900.2, ENSMUST00000112281.8
    Conserved Domains (1) summary
    cl22855
    Location:489
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    125209583..125214014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505901.5XP_006505964.1  CD27 antigen isoform X4

    Conserved Domains (1) summary
    cl22855
    Location:445
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  2. XM_006505900.5XP_006505963.1  CD27 antigen isoform X3

    Conserved Domains (2) summary
    cd00185
    Location:1062
    TNFRSF; CRD1 [structural motif]
    cl22855
    Location:489
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  3. XM_011241288.3XP_011239590.1  CD27 antigen isoform X2

    Conserved Domains (2) summary
    cd00185
    Location:6277
    TNFRSF; CRD3 [structural motif]
    cl22855
    Location:479
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
  4. XM_006505898.5XP_006505961.1  CD27 antigen isoform X1

    Conserved Domains (1) summary
    cd13408
    Location:4123
    TNFRSF7; Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), also known as CD27