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CD27 CD27 molecule [ Homo sapiens (human) ]

Gene ID: 939, updated on 23-Nov-2021


Official Symbol
CD27provided by HGNC
Official Full Name
CD27 moleculeprovided by HGNC
Primary source
See related
Ensembl:ENSG00000139193 MIM:186711
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T14; S152; Tp55; TNFRSF7; S152. LPFS2
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
Broad expression in lymph node (RPKM 38.5), spleen (RPKM 21.6) and 14 other tissues See more
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Genomic context

See CD27 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6444867..6451718)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6554121..6560879)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 10 Neighboring gene CD27 antisense RNA 1 Neighboring gene signal recognition particle 14 pseudogene 1 Neighboring gene TAP binding protein like Neighboring gene vesicle associated membrane protein 1 Neighboring gene plakophilin 2 pseudogene 1

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CD27 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of CD27molecule (TNFRSF7: tumor necrosis factor receptor superfamily, member 7) in human B cells PubMed
env HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp140 upregulates the expression of the B cell activation marker CD38 and the memory B cell marker CD27 PubMed
Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD27 (TNFRSF7) PubMed
Tat tat HIV-1 Tat upregulates the expression of CD27 in stimulated CD8+T lymphocytes PubMed
Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD27 (TNFRSF7) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC20393

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
located_in extracellular region NAS
Non-traceable Author Statement
more info
located_in integral component of plasma membrane NAS
Non-traceable Author Statement
more info
located_in plasma membrane TAS
Traceable Author Statement
more info

General protein information

Preferred Names
CD27 antigen
CD27L receptor
T cell activation antigen S152
T-cell activation antigen CD27
tumor necrosis factor receptor superfamily, member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


  1. NG_031995.1 RefSeqGene

    GenBank, FASTA, Sequence Viewer (Graphics), LRG_357

mRNA and Protein(s)

  1. NM_001242.5NP_001233.2  CD27 antigen precursor

    Status: REVIEWED

    Source sequence(s)
    Consensus CDS
    ENSP00000266557.3, ENST00000266557.4
    Conserved Domains (1) summary
    TNFRSF7; Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), also known as CD27

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020232.1XP_016875721.1  CD27 antigen isoform X1

  2. XM_017020234.1XP_016875723.1  CD27 antigen isoform X3

  3. XM_017020233.2XP_016875722.1  CD27 antigen isoform X2

  4. XM_011521042.3XP_011519344.1  CD27 antigen isoform X4

    Conserved Domains (1) summary
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
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