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Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b [ Mus musculus (house mouse) ]

Gene ID: 21938, updated on 19-Feb-2024

Summary

Official Symbol
Tnfrsf1bprovided by MGI
Official Full Name
tumor necrosis factor receptor superfamily, member 1bprovided by MGI
Primary source
MGI:MGI:1314883
See related
Ensembl:ENSMUSG00000028599 AllianceGenome:MGI:1314883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p75; TNFBR; Tnfr2; CD120b; TNF-R2; TNFR80; TNFRII; Tnfr-1; TNF-R75; TNF-R-II; TNF-alphaR2; TNFalpha-R2
Summary
Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including negative regulation of extracellular matrix constituent secretion; regulation of nervous system development; and semi-lunar valve development. Acts upstream of or within several processes, including RNA destabilization; apoptotic signaling pathway; and negative regulation of inflammatory response. Located in membrane raft. Is expressed in several structures, including blood; dorsal aorta; extraembryonic component; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Orthologous to human TNFRSF1B (TNF receptor superfamily member 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 20.1), mammary gland adult (RPKM 14.7) and 20 other tissues See more
Orthologs
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Genomic context

See Tnfrsf1b in Genome Data Viewer
Location:
4 E1; 4 78.17 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (144938938..144973453, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (145212368..145246870, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 13D Neighboring gene predicted gene, 42344 Neighboring gene STARR-positive B cell enhancer ABC_E11264 Neighboring gene STARR-positive B cell enhancer mm9_chr4:144575978-144576279 Neighboring gene predicted gene, 36317 Neighboring gene STARR-seq mESC enhancer starr_11999 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:144609228-144609381 Neighboring gene STARR-seq mESC enhancer starr_12001 Neighboring gene STARR-positive B cell enhancer mm9_chr4:144741051-144741352 Neighboring gene STARR-positive B cell enhancer mm9_chr4:144784820-144785121 Neighboring gene STARR-seq mESC enhancer starr_12004 Neighboring gene STARR-positive B cell enhancer ABC_E11265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:144832691-144832800 Neighboring gene STARR-positive B cell enhancer ABC_E8008 Neighboring gene STARR-seq mESC enhancer starr_12014 Neighboring gene predicted gene, 36233 Neighboring gene STARR-seq mESC enhancer starr_12016 Neighboring gene STARR-positive B cell enhancer mm9_chr4:144885570-144885871 Neighboring gene tumor necrosis factor receptor superfamily, member 8 Neighboring gene STARR-positive B cell enhancer ABC_E1663

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tumor necrosis factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tumor necrosis factor binding ISO
Inferred from Sequence Orthology
more info
 
enables tumor necrosis factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tumor necrosis factor receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables tumor necrosis factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA destabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aortic valve development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glial cell-neuron signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cardiac muscle hypertrophy IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of extracellular matrix constituent secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuroinflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of neuroinflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process involved in morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of membrane protein ectodomain proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myelination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of oligodendrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pulmonary valve development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of T cell cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of T cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytokine production involved in immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of myelination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of neuroinflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in varicosity ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tumor necrosis factor receptor superfamily member 1B
Names
TNF receptor beta chain
TNF-RII
TNFR-II
p75 TNFR
p80 TNF-alpha receptor
tumor necrosis factor receptor 2
tumor necrosis factor receptor type II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011610.3NP_035740.2  tumor necrosis factor receptor superfamily member 1B precursor

    See identical proteins and their annotated locations for NP_035740.2

    Status: VALIDATED

    Source sequence(s)
    AK140332, BY489212
    Consensus CDS
    CCDS18914.1
    UniProtKB/Swiss-Prot
    O88734, P25119, P97893
    UniProtKB/TrEMBL
    Q3U2A9, Q545P4
    Related
    ENSMUSP00000030336.5, ENSMUST00000030336.11
    Conserved Domains (1) summary
    cd10577
    Location:40203
    TNFRSF1B; Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    144938938..144973453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163965.1XP_036019858.1  tumor necrosis factor receptor superfamily member 1B isoform X1

    Conserved Domains (3) summary
    COG3889
    Location:69138
    COG3889; Predicted periplasmic protein [Function unknown]
    cd00185
    Location:2464
    TNFRSF; CRD4 [structural motif]
    cl22855
    Location:164
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)