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Tnfaip2 tumor necrosis factor, alpha-induced protein 2 [ Mus musculus (house mouse) ]

Gene ID: 21928, updated on 2-Nov-2024

Summary

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Official Symbol
Tnfaip2provided by MGI
Official Full Name
tumor necrosis factor, alpha-induced protein 2provided by MGI
Primary source
MGI:MGI:104960
See related
Ensembl:ENSMUSG00000021281 AllianceGenome:MGI:104960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B94; M-sec; Tnfip2; tnfb94; Exoc3l3
Summary
Predicted to enable SNARE binding activity. Predicted to be involved in exocyst localization and exocytosis. Predicted to be part of exocyst. Is expressed in several structures, including embryo mesenchyme; future brain; genitourinary system; immune system; and sensory organ. Used to study focal segmental glomerulosclerosis. Orthologous to human TNFAIP2 (TNF alpha induced protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 39.6), liver E14.5 (RPKM 31.1) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Tnfaip2 in Genome Data Viewer
Location:
12 F1; 12 60.99 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111408898..111421452)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111442450..111455018)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene LBH domain containing 2 Neighboring gene exocyst complex component 3-like 4 Neighboring gene predicted gene, 40578 Neighboring gene predicted gene 266 Neighboring gene STARR-positive B cell enhancer ABC_E138 Neighboring gene small nucleolar RNA, H/ACA box 28 Neighboring gene eukaryotic translation initiation factor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tnfaip2 promotes atherogenesis by enhancing oxidative stress induced inflammation. Jin G, et al. Mol Immunol, 2022 Nov. PMID 36084515
  2. Protective effect of the tunneling nanotube-TNFAIP2/M-sec system on podocyte autophagy in diabetic nephropathy. Barutta F, et al. Autophagy, 2023 Feb. PMID 35659195, Free PMC Article
  3. Protective Role of the M-Sec-Tunneling Nanotube System in Podocytes. Barutta F, et al. J Am Soc Nephrol, 2021 May 3. PMID 33722931, Free PMC Article
  4. Screening UFMylation-associated genes in heart tissues of Ufm1-transgenic mice. Jiajia H, et al. BMC Cardiovasc Disord, 2023 Nov 18. PMID 37980507, Free PMC Article
  5. M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex. Hase K, et al. Nat Cell Biol, 2009 Dec. PMID 19935652

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Screening UFMylation-associated genes in heart tissues of Ufm1-transgenic mice.
    Title: Screening UFMylation-associated genes in heart tissues of Ufm1-transgenic mice.
  2. Tnfaip2 promotes atherogenesis by enhancing oxidative stress induced inflammation.
    Title: Tnfaip2 promotes atherogenesis by enhancing oxidative stress induced inflammation.
  3. Knockdown of TNFaip2 in Raw264.7 cells inhibited formation of tunneling nanotubes.
    Title: M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in exocyst localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exocyst IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tumor necrosis factor alpha-induced protein 2
Names
TNF alpha-induced protein 2
primary response gene B94 protein
tumor necrosis factor induced protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009396.2 → NP_033422.2  tumor necrosis factor alpha-induced protein 2

    See identical proteins and their annotated locations for NP_033422.2

    Status: VALIDATED

    Source sequence(s)
    BP767166, BY202445, L24118
    Consensus CDS
    CCDS26178.2
    UniProtKB/Swiss-Prot
    Q3T9B0, Q3TCH9, Q61333, Q922G1
    UniProtKB/TrEMBL
    D3Z4L9
    Related
    ENSMUSP00000099806.4, ENSMUST00000102745.10
    Conserved Domains (1) summary
    pfam06046
    Location:157 → 688
    Sec6; Exocyst complex component Sec6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    111408898..111421452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515793.5 → XP_006515856.1  tumor necrosis factor alpha-induced protein 2 isoform X2

    Conserved Domains (1) summary
    cl19885
    Location:157 → 412
    Sec6; Exocyst complex component Sec6

  2. XM_036157378.1 → XP_036013271.1  tumor necrosis factor alpha-induced protein 2 isoform X1

RNA

  1. XR_381521.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61333.2 GenPept UniProtKB/Swiss-Prot:Q61333

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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