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TNFAIP2 TNF alpha induced protein 2 [ Homo sapiens (human) ]

Gene ID: 7127, updated on 4-Jul-2019

Summary

Official Symbol
TNFAIP2provided by HGNC
Official Full Name
TNF alpha induced protein 2provided by HGNC
Primary source
HGNC:HGNC:11895
See related
Ensembl:ENSG00000185215 MIM:603300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B94; EXOC3L3
Summary
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in urinary bladder (RPKM 54.5), spleen (RPKM 53.6) and 22 other tissues See more
Orthologs

Genomic context

See TNFAIP2 in Genome Data Viewer
Location:
14q32.32
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (103121175..103137439)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103589762..103603776)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene LBH domain containing 2 Neighboring gene exocyst complex component 3 like 4 Neighboring gene long intergenic non-protein coding RNA 677 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 11 Neighboring gene ribosomal protein L21 pseudogene 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
exocyst localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
exocyst IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
tumor necrosis factor alpha-induced protein 2
Names
exocyst complex component 3-like 3
primary response gene B94 protein
tumor necrosis factor, alpha induced protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371220.1NP_001358149.1  tumor necrosis factor alpha-induced protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL161669
  2. NM_001371221.1NP_001358150.1  tumor necrosis factor alpha-induced protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL161669
  3. NM_006291.3NP_006282.2  tumor necrosis factor alpha-induced protein 2 isoform 1

    See identical proteins and their annotated locations for NP_006282.2

    Status: REVIEWED

    Source sequence(s)
    AL161669
    Consensus CDS
    CCDS9979.1
    UniProtKB/Swiss-Prot
    Q03169
    Related
    ENSP00000332326.1, ENST00000333007.6
    Conserved Domains (1) summary
    pfam06046
    Location:122651
    Sec6; Exocyst complex component Sec6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    103121175..103137439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537115.2XP_011535417.1  tumor necrosis factor alpha-induced protein 2 isoform X3

  2. XM_011537114.2XP_011535416.1  tumor necrosis factor alpha-induced protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011535416.1

    UniProtKB/Swiss-Prot
    Q03169
    Related
    ENSP00000452634.1, ENST00000560869.5
    Conserved Domains (1) summary
    pfam06046
    Location:122651
    Sec6; Exocyst complex component Sec6
  3. XM_011537112.2XP_011535414.1  tumor necrosis factor alpha-induced protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011535414.1

    Conserved Domains (1) summary
    pfam06046
    Location:122651
    Sec6; Exocyst complex component Sec6
  4. XM_006720243.3XP_006720306.1  tumor necrosis factor alpha-induced protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006720306.1

    Conserved Domains (1) summary
    pfam06046
    Location:122651
    Sec6; Exocyst complex component Sec6
  5. XM_011537113.2XP_011535415.1  tumor necrosis factor alpha-induced protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011535415.1

    Conserved Domains (1) summary
    pfam06046
    Location:122651
    Sec6; Exocyst complex component Sec6
  6. XM_017021616.1XP_016877105.1  tumor necrosis factor alpha-induced protein 2 isoform X1

    Conserved Domains (1) summary
    pfam06046
    Location:122651
    Sec6; Exocyst complex component Sec6
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