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Tnnc1 troponin C, cardiac/slow skeletal [ Mus musculus (house mouse) ]

Gene ID: 21924, updated on 7-Aug-2018

Summary

Official Symbol
Tnnc1provided by MGI
Official Full Name
troponin C, cardiac/slow skeletalprovided by MGI
Primary source
MGI:MGI:98779
See related
Ensembl:ENSMUSG00000091898 Vega:OTTMUSG00000035921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TnC; cTnC; cTnI; tncc; AI874626
Expression
Biased expression in heart adult (RPKM 1462.3) and limb E14.5 (RPKM 100.7) See more
Orthologs

Genomic context

See Tnnc1 in Genome Data Viewer
Location:
14 B; 14 19.09 cM
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (31208312..31211711)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (32021498..32024897)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase domain containing 2 Neighboring gene stabilin 1 Neighboring gene nischarin Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G Neighboring gene PHD finger protein 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from BioSystems

  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
    Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Cardiac muscle contraction, conserved biosystem (from KEGG)
    Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
    Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dilated cardiomyopathy, conserved biosystem (from KEGG)
    Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Striated Muscle Contraction, organism-specific biosystem (from REACTOME)
    Striated Muscle Contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Striated Muscle Contraction, organism-specific biosystem (from WikiPathways)
    Striated Muscle Contraction, organism-specific biosystem
    Striated Muscle Contraction

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
troponin I binding ISO
Inferred from Sequence Orthology
more info
 
troponin T binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
diaphragm contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of muscle contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of muscle filament sliding speed IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to metal ion ISO
Inferred from Sequence Orthology
more info
 
skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transition between fast and slow fiber IDA
Inferred from Direct Assay
more info
PubMed 
ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cardiac Troponin complex ISO
Inferred from Sequence Orthology
more info
 
contractile fiber ISO
Inferred from Sequence Orthology
more info
 
troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
troponin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
troponin C, slow skeletal and cardiac muscles

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009393.3NP_033419.1  troponin C, slow skeletal and cardiac muscles

    See identical proteins and their annotated locations for NP_033419.1

    Status: VALIDATED

    Source sequence(s)
    AC108416
    Consensus CDS
    CCDS36854.1
    UniProtKB/Swiss-Prot
    P19123
    Related
    ENSMUSP00000131991.1, OTTMUSP00000045387, ENSMUST00000169169.7
    Conserved Domains (1) summary
    cl25352
    Location:9157
    EFh_PEF; The penta-EF hand (PEF) family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    31208312..31211711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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