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Tnnc1 troponin C, cardiac/slow skeletal [ Mus musculus (house mouse) ]

Gene ID: 21924, updated on 2-Apr-2024

Summary

Official Symbol
Tnnc1provided by MGI
Official Full Name
troponin C, cardiac/slow skeletalprovided by MGI
Primary source
MGI:MGI:98779
See related
Ensembl:ENSMUSG00000091898 AllianceGenome:MGI:98779
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TnC; cTnC; cTnI; tncc
Summary
Enables actin filament binding activity. Involved in regulation of ATPase activity and regulation of muscle filament sliding speed. Acts upstream of or within transition between fast and slow fiber. Predicted to be located in contractile fiber. Predicted to be part of cardiac Troponin complex. Is expressed in several structures, including alimentary system; heart; liver; metanephros; and skeletal muscle. Used to study hypertrophic cardiomyopathy 13. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Z; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 13. Orthologous to human TNNC1 (troponin C1, slow skeletal and cardiac type). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 1462.3) and limb E14.5 (RPKM 100.7) See more
Orthologs
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Genomic context

See Tnnc1 in Genome Data Viewer
Location:
14 B; 14 19.09 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30930274..30933671)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31208312..31211729)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene stabilin 1 Neighboring gene predicted gene, 52148 Neighboring gene nischarin Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G Neighboring gene STARR-positive B cell enhancer ABC_E7302 Neighboring gene PHD finger protein 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables troponin I binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables troponin I binding ISO
Inferred from Sequence Orthology
more info
 
enables troponin T binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cardiac muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in diaphragm contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ATP-dependent activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of muscle filament sliding speed IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to metal ion ISO
Inferred from Sequence Orthology
more info
 
involved_in skeletal muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within transition between fast and slow fiber IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of cardiac Troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cardiac Troponin complex ISO
Inferred from Sequence Orthology
more info
 
located_in contractile fiber ISO
Inferred from Sequence Orthology
more info
 
part_of troponin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
troponin C, slow skeletal and cardiac muscles

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009393.4NP_033419.1  troponin C, slow skeletal and cardiac muscles

    See identical proteins and their annotated locations for NP_033419.1

    Status: VALIDATED

    Source sequence(s)
    AC108416
    Consensus CDS
    CCDS36854.1
    UniProtKB/Swiss-Prot
    P19123
    Related
    ENSMUSP00000131991.2, ENSMUST00000169169.8
    Conserved Domains (1) summary
    PTZ00184
    Location:9157
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30930274..30933671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)